{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:04:58Z","timestamp":1790665498482,"version":"4.1.0"},"reference-count":85,"publisher":"BMJ","issue":"4","funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Mycoplasma genitalium<\/jats:italic>\n                      is a common cause of non-gonococcal non-chlamydial urethritis and cervicitis. Testing of asymptomatic populations has been proposed, but prevalence in asymptomatic populations is not well established. We aimed to estimate the prevalence of\n                      <jats:italic>M. genitalium<\/jats:italic>\n                      in the general population, pregnant women, men who have sex with men (MSM), commercial sex workers (CSWs) and clinic-based samples,\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched Embase, Medline, IndMED, African Index Medicus and LILACS from 1 January 1991 to 12 July 2016 without language restrictions. We included studies with 500 participants or more. Two reviewers independently screened and selected studies and extracted data. We examined forest plots and conducted random-effects meta-analysis to estimate prevalence, if appropriate. Between-study heterogeneity was examined using the I\n                      <jats:sup>2<\/jats:sup>\n                      statistic and meta-regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 3316 screened records, 63 were included. In randomly selected samples from the general population, the summary prevalence was 1.3% (95% CI 1.0% to 1.8%, I\n                      <jats:sup>2<\/jats:sup>\n                      41.5%, three studies, 9091 people) in countries with higher levels of development and 3.9% (95% CI 2.2 to 6.7, I\n                      <jats:sup>2<\/jats:sup>\n                      89.2%, three studies, 3809 people) in countries with lower levels. Prevalence was similar in women and men (P=0.47). In clinic based samples, prevalence estimates were higher, except in asymptomatic patients (0.8%, 95%\u2009CI 0.4 to 1.4, I\n                      <jats:sup>2<\/jats:sup>\n                      0.0%, three studies, 2889 people). Summary prevalence estimates were, in the following groups: pregnant women 0.9% (95% CI 0.6% to 1.4%, I\n                      <jats:sup>2<\/jats:sup>\n                      0%, four studies, 3472 people), MSM in the community 3.2% (95% CI 2.1 to 5.1, I\n                      <jats:sup>2<\/jats:sup>\n                      78.3%, five studies, 3012 people) and female CSWs in the community 15.9% (95% CI 13.5 to 18.9, I\n                      <jats:sup>2<\/jats:sup>\n                      79.9%, four studies, 4006 people).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      This systematic review can inform testing guidelines for\n                      <jats:italic>M. genitalium<\/jats:italic>\n                      . The low estimated prevalence of\n                      <jats:italic>M. genitalium<\/jats:italic>\n                      in the general population, pregnant women and asymptomatic attenders at clinics does not support expansion of testing to these groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration numbers<\/jats:title>\n                    <jats:p>\n                      PROSPERO:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.php?ID=CRD42015020420\" ext-link-type=\"uri\">CRD42015020420<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/sextrans-2017-053384","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T12:21:50Z","timestamp":1518178910000},"page":"255-262","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":233,"title":["Prevalence of\n                    <i>Mycoplasma genitalium<\/i>\n                    in different population groups: systematic review andmeta-analysis"],"prefix":"10.1136","volume":"94","author":[{"given":"Lukas","family":"Baumann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Cina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Egli-Gany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrofora","family":"Goutaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian S","family":"Halbeisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian-Reto","family":"Lohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammad","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pippa","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-8986","authenticated-orcid":false,"given":"Nicola","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"2020050723331613000_94.4.255.1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-11"},{"key":"2020050723331613000_94.4.255.2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s11908-010-0114-3","article-title":"Mycoplasma genitalium: is it a\u00a0sexually transmitted pathogen?","volume":"12","author":"Manhart","year":"2010","journal-title":"Curr Infect Dis Rep"},{"key":"2020050723331613000_94.4.255.3","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00003-06"},{"key":"2020050723331613000_94.4.255.4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ312"},{"key":"2020050723331613000_94.4.255.5","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0140-6736(81)92461-2","article-title":"A newly discovered mycoplasma in the human urogenital tract","volume":"1","author":"Tully","year":"1981","journal-title":"Lancet"},{"key":"2020050723331613000_94.4.255.6","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3181b9d825"},{"key":"2020050723331613000_94.4.255.7","doi-asserted-by":"publisher","DOI":"10.29074\/ascls.27.1.47"},{"key":"2020050723331613000_94.4.255.8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4111\/kju.2011.52.10.703","article-title":"The prevalence and clinical significance of urethritis and cervicitis in asymptomatic people by use of multiplex polymerase chain reaction","volume":"52","author":"Kim","year":"2011","journal-title":"Korean J Urol"},{"issue":"suppl_2","key":"2020050723331613000_94.4.255.9","doi-asserted-by":"crossref","first-page":"S406","DOI":"10.1093\/infdis\/jix104","article-title":"Mycoplasma genitalium: accurate diagnosis is necessary for adequate treatment","volume":"216","author":"Gaydos","year":"2017","journal-title":"J Infect Dis"},{"key":"2020050723331613000_94.4.255.10","unstructured":"Raffle A , Gray M . 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