{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:10:25Z","timestamp":1774653025771,"version":"3.50.1"},"reference-count":9,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2018,9,18]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Women living with HIV (WLHIV) face disproportionately higher risks of acquiring human papillomavirus (HPV) compared with HIV negative counterparts. We aimed to investigate the prevalence of HPV in WLHIV in Chinese hospital setting and identify associated factors to the progression of late-stage cervical intraepithelial neoplasia (CIN2+) in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective study collected data from 183 WLHIV on antiretroviral treatment (ART), based on reproductive health questionnaires. Gynaecological examination results including serum (for HIV viral load, CD4 T-cell count, hepatitis B infections, syphilis) and vaginal swabs for common bacterial sexually transmitted infections (STIs). Multivariate-logistic regression was applied to analyze the contributing factors to CIN2+.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HIV coinfection with other Sexually Transmitted Infections (STIs) were observed in 99 participants (54.1%, (99\/183)). HPV (43.7% (80\/183)) was the most prevalent STI. The three most prevalent HPV subtypes were all high-risk HPV (HR-HPV), including HPV52 (33.8% (27\/80)), HPV58 (21.3% (17\/80)) and HPV33 (13.75% (11\/80)). About a third (37.5%, 30\/80) of women with HPV had HR-HPV. Multiple HPV coinfections were common in HIV-HPV coinfected women (41.3%, 33\/80). Cytological examinations revealed that 77.5% (62\/80) HPV+ women had detectable cervical lesions. In comparison, only 4.9% (5\/103) HPV negative womenwith Atypia and 1.0% (1\/103) with CIN1 were diagnosed. Multivariate logistic regression revealed that HPV16 (OR=19.04, 2.53 to 122.92; p=0.004) and HPV18 (OR=11.54, 1.45 to 91.64; p=0.021) infections were significantly associated with CIN2+ in HIV-HPV coinfected women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high prevalence of HPV was found in women on ART. HPV16\/18 infection are strong associated factors to CIN2+ in HIV-HPV coinfected women.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2018-053636","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T12:47:54Z","timestamp":1539953274000},"page":"140-144","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Human papillomavirus infection and associated factors for cervical intraepithelial neoplasia in women living with HIV in China: a cross-sectional study"],"prefix":"10.1136","volume":"95","author":[{"given":"Qian","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaosong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-7403","authenticated-orcid":false,"given":"Jason J","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-084X","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"2024092304402080000_95.2.140.1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji073"},{"key":"2024092304402080000_95.2.140.2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.7314\/APJCP.2012.13.1.091","article-title":"HPV prevalence and cervical intraepithelial neoplasia among HIV-infected women in Yunnan Province, China: a pilot study","volume":"13","author":"Zhang","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"key":"2024092304402080000_95.2.140.3","first-page":"185","article-title":"[Analysis of cervical HPV infection in HIV positive Chinese women]","volume":"47","author":"Zhang","year":"2012","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"2024092304402080000_95.2.140.4","unstructured":"WHO , 2014. Comprehensive cervical cancer control a guide to essential practice. Available from: http:\/\/www.who.int\/reproductivehealth\/publications\/cancers\/cervical-cancer-guide\/en\/ [accessed 2 Feb 2018]."},{"key":"2024092304402080000_95.2.140.5","first-page":"596","article-title":"Epidemiological investigation of the prevalence of high risk human papillomavirus and its correlation with cervical intraepithelial neoplasia in 4874 women in Guangxi Province","volume":"27","author":"Liu","year":"2011","journal-title":"Journal of Practical Obstetrics and Gynecology"},{"key":"2024092304402080000_95.2.140.6","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-015-0998-5","article-title":"Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China","volume":"15","author":"Wang","year":"2015","journal-title":"BMC Infect Dis"},{"key":"2024092304402080000_95.2.140.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"2024092304402080000_95.2.140.8","doi-asserted-by":"crossref","DOI":"10.1186\/s13027-017-0116-y","article-title":"Human papillomavirus genotypes associated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China","volume":"12","author":"Zhao","year":"2017","journal-title":"Infect Agent Cancer"},{"key":"2024092304402080000_95.2.140.9","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1002\/cam4.1321","article-title":"Significant variations in the cervical cancer screening rate in China by individual-level and geographical measures of socioeconomic status: a multilevel model analysis of a nationally representative survey dataset","volume":"7","author":"Bao","year":"2018","journal-title":"Cancer Med"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2018-053636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T11:40:37Z","timestamp":1727091637000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2018-053636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,18]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,25]]},"published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1136\/sextrans-2018-053636"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2018-053636","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,18]]}}}