{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T11:26:36Z","timestamp":1794223596527,"version":"4.8.0"},"reference-count":16,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2019,4,2]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The size of the population of men who have sex with men (MSM) who may be eligible for HIV pre-exposure prophylaxis (HIV-PrEP) in England remains unknown. To plan for a national PrEP implementation trial, we estimated the number of MSM attending sexual health clinics (SHCs) that may be eligible for HIV-PrEP in England.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sexually transmitted infection (STI) surveillance data from 2010 to 2015 from the GUMCAD surveillance system were used to estimate the annual number of HIV-negative MSM who may be eligible for HIV-PrEP in England. Based on national eligibility criteria, we identified HIV-negative MSM attending SHCs with a HIV-negative test in the past year and used diagnosed bacterial STI (past year) in this group as a proxy for condomless sex and eligibility for HIV-PrEP. We estimated HIV incidence per 100 person-years (py) in these groups in 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 2010\u20132015, the number of HIV-negative MSM attending SHCs with a HIV-negative test in the past year doubled from 14\u2009643 to 29 023, and HIV incidence in this group was 1.9 (95% CI 1.6 to 2.2) per 100 py in 2014. In the same period, the subgroup with a bacterial STI diagnosis (past year), and therefore considered potentially eligible for HIV-PrEP in this analysis, increased from 4365 (30%) to 10\u2009276 (35%). HIV incidence in this subgroup was 3.3 (95% CI 2.7 to 4.0) per 100 py in 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In 2015, approximately 10 000 HIV-negative MSM were considered potentially eligible for HIV-PrEP based on clinic history in GUMCAD. These data were used to inform the initial recruitment target for the PrEP Impact Trial and will inform future evaluations at a population level.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2019-054009","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T21:19:47Z","timestamp":1555967987000},"page":"484-487","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Preparing for PrEP: estimating the size of the population eligible for HIV pre-exposure prophylaxis among men who have sex with men in England"],"prefix":"10.1136","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6103-9975","authenticated-orcid":false,"given":"Holly D","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarika","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-7286","authenticated-orcid":false,"given":"Hamish","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh Jun","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Furegato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9658-7798","authenticated-orcid":false,"given":"John Michael","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-7702","authenticated-orcid":false,"given":"Gwenda","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O Noel","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"2024092304402114000_95.7.484.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00056-2"},{"key":"2024092304402114000_95.7.484.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506273"},{"key":"2024092304402114000_95.7.484.3","doi-asserted-by":"crossref","unstructured":"Grulich AE , Guy R , Amin J , et al . Population-level effectiveness of rapid, targeted, high-coverage roll-out of HIV pre-exposure prophylaxis in men who have sex with men: the EPIC-NSW prospective cohort study. The Lancet 2018.","DOI":"10.1016\/S2352-3018(18)30215-7"},{"key":"2024092304402114000_95.7.484.4","unstructured":"Nash S , Desai S , Croxford S . Progress towards ending the HIV epidemic in the United Kingdom: 2018 report. London Public Health England; 2018."},{"key":"2024092304402114000_95.7.484.5","doi-asserted-by":"crossref","unstructured":"Mayor S . NHS to fund large trial of pre-exposure prophylaxis for HIV prevention. BMJ 2016;355.doi:10.1136\/bmj.i6537","DOI":"10.1136\/bmj.i6537"},{"key":"2024092304402114000_95.7.484.6","unstructured":"Public health England, NHS England and St Stephen's clinical research . PrEP impact trial. Available: https:\/\/www.prepimpacttrial.org.uk\/ [Accessed 10 Jul 2018]."},{"key":"2024092304402114000_95.7.484.7","doi-asserted-by":"crossref","unstructured":"Savage EJ , Mohammed H , Leong G , et al . Improving surveillance of sexually transmitted infections using mandatory electronic clinical reporting: the genitourinary medicine clinic activity dataset, England, 2009 to 2013. Euro Surveill 2014;19.doi:10.2807\/1560-7917.ES2014.19.48.20981","DOI":"10.2807\/1560-7917.ES2014.19.48.20981"},{"key":"2024092304402114000_95.7.484.8","unstructured":"NHS England Specialised Services Clinical Reference Group for HIV . Clinical commissioning policy proposition: pre-exposure prophylaxis (PrEP) to prevent the acquisition of HIV in adults. Available: https:\/\/www.engage.england.nhs.uk\/consultation\/specialised-services\/user_uploads\/f03x06-policy-proposition.pdf [Accessed 21 Dec 2016]."},{"key":"2024092304402114000_95.7.484.9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/hiv.12498","article-title":"HIV incidence in an open national cohort of men who have sex with men attending sexually transmitted infection clinics in England","volume":"18","author":"Desai","year":"2017","journal-title":"HIV Med"},{"key":"2024092304402114000_95.7.484.10","doi-asserted-by":"crossref","DOI":"10.2196\/resprot.4873","article-title":"A cross-sectional study on attitudes to and understanding of risk of acquisition of HIV: design, methods and participant characteristics","volume":"5","author":"Sewell","year":"2016","journal-title":"JMIR Res Protoc"},{"key":"2024092304402114000_95.7.484.11","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2017-053268"},{"key":"2024092304402114000_95.7.484.12","unstructured":"Public Health England and St Stephen's Clinical Research . PrEP impact trial: a pragmatic health technology assessment of PrEP and implementation. Protocol number SSCR104. version 2, 2017. Available: https:\/\/www.prepimpacttrial.org.uk\/protocol [Accessed 19 Oct 2018]."},{"key":"2024092304402114000_95.7.484.13","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000101"},{"key":"2024092304402114000_95.7.484.14","unstructured":"Health Protection Scotland and Information Services Division . Implementation of HIV PrEP in Scotland: First Year Report. Glasgow: Health Protection Scotland and Information Services Division, 2019."},{"key":"2024092304402114000_95.7.484.15","unstructured":"NHS England . PrEP trial update - June 2018. Available: https:\/\/www.england.nhs.uk\/commissioning\/spec-services\/npc-crg\/blood-and-infection-group-f\/f03\/prep-trial-updates\/ [Accessed 31 Aug 2018]."},{"key":"2024092304402114000_95.7.484.16","unstructured":"Public Health England . GUMCADv3 pilot. Available: https:\/\/www.gov.uk\/guidance\/genitourinary-medicine-clinic-activity-dataset-gumcadv3-pilot [Accessed 21 Dec 2016]."}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2019-054009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T11:40:49Z","timestamp":1727091649000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2019-054009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,22]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,10,17]]},"published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1136\/sextrans-2019-054009"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2019-054009","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,22]]}}}