{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:05:02Z","timestamp":1790665502926,"version":"4.1.0"},"reference-count":11,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2020,6,14]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>In recent years, resistance in<jats:italic>Mycoplasma genitalium<\/jats:italic>(MG) to first-line (azithromycin) and second-line (moxifloxacin) treatment has been increasingly reported worldwide, however, no data regarding the south of Spain are available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To determine resistance rates, MG-positive samples collected from June 2018 to June 2019 were analysed by sequencing the 23S rRNA and parC genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 77 patients (24 men having sex with men (MSM), 30 heterosexual men and 23 women) were included. Resistance-associated mutations against macrolide and fluoroquinolones were found in 36.4% (95% CI 25.7% to 48.1%) and 9.1% (95% CI 3.7% to 17.8%) of the patients, respectively. Being MSM and having had another STI in the last year were significantly associated with macrolide-resistant MG infection, while no associations were found with resistance to fluoroquinolones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Testing for resistance to first-line and second-line drugs against MG should be recommended for the general population and mandatory for the MSM population. We suggest that empiric azithromycin use for STI management should be avoided.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2019-054386","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T21:21:58Z","timestamp":1594675318000},"page":"8-10","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Macrolide and fluoroquinolone resistance of<i>Mycoplasma genitalium<\/i>in southern Spain, 2018\u20132019"],"prefix":"10.1136","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4318-858X","authenticated-orcid":false,"given":"Adolfo","family":"de Salazar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Barrientos-Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Espadafor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fuentes-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Chueca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-781X","authenticated-orcid":false,"given":"Federico","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"2024092304150912000_97.1.8.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2016.268"},{"key":"2024092304150912000_97.1.8.2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13849"},{"key":"2024092304150912000_97.1.8.3","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/cid\/ciy477","article-title":"Outcomes of resistance-guided sequential treatment of mycoplasma genitalium infections: a prospective evaluation","volume":"68","author":"Read","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2024092304150912000_97.1.8.4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01053-16"},{"key":"2024092304150912000_97.1.8.5","doi-asserted-by":"crossref","first-page":"e01555","DOI":"10.1128\/JCM.01555-18","article-title":"Levels of ycoplasma genitalium antimicrobial resistance differ by both region and gender in the state of Queensland, Australia: implications for treatment guidelines","volume":"57","author":"Sweeney","year":"2019","journal-title":"J Clin Microbiol"},{"key":"2024092304150912000_97.1.8.6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.eimc.2018.10.003","article-title":"Guided antibiotic therapy for Mycoplasma genitalium infections: analysis of mutations associated with resistance to macrolides and fluoroquinolones","volume":"37","author":"Pi\u00f1eiro","year":"2019","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"2024092304150912000_97.1.8.7","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000631"},{"key":"2024092304150912000_97.1.8.8","doi-asserted-by":"publisher","DOI":"10.1177\/0956462416648585"},{"key":"2024092304150912000_97.1.8.9","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12792"},{"key":"2024092304150912000_97.1.8.10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175763","article-title":"Prevalence of macrolide and fluoroquinolone resistance-mediating mutations in Mycoplasma genitalium in five cities in Russia and Estonia","volume":"12","author":"Shipitsyna","year":"2017","journal-title":"PLoS One"},{"key":"2024092304150912000_97.1.8.11","article-title":"Resistance-guided antimicrobial therapy using doxycycline-moxifloxacin and doxycycline-2.5g azithromycin for the treatment of Mycoplasma genitalium infection: efficacy and tolerability","author":"Durukan","year":"2019","journal-title":"Clin Infect Dis"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2019-054386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T11:15:35Z","timestamp":1727090135000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2019-054386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,13]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,15]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/sextrans-2019-054386"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2019-054386","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,13]]}}}