{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:02:41Z","timestamp":1769605361509,"version":"3.49.0"},"reference-count":12,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["Research for Patient Benefit (RfPB) Programme (Gra"],"award-info":[{"award-number":["Research for Patient Benefit (RfPB) Programme (Gra"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011950","name":"BMA Foundation for Medical Research","doi-asserted-by":"crossref","award":["TP Gunton Award"],"award-info":[{"award-number":["TP Gunton Award"]}],"id":[{"id":"10.13039\/501100011950","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Wellcome Trust Institution Strategic Support Fund","award":["204809\/Z\/16\/Z"],"award-info":[{"award-number":["204809\/Z\/16\/Z"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2020,7,26]]},"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oropharyngeal squamous cell carcinoma is the most common human papillomavirus (HPV)-associated cancer in the UK, but little is known about the prevalence of oropharyngeal HPV in sexually active teenagers. We investigated reported HPV vaccination coverage (in females) and prevalence of oropharyngeal HPV in sexually active students attending six technical colleges in London, UK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 2017, we obtained mouthwash samples and questionnaires from male and female students taking part in the \u2018Test n Treat\u2019 chlamydia screening trial. Samples were subjected to HPV genotyping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 232 participants approached, 202 (87%) provided a mouthwash sample and questionnaire. Participants\u2019 median age was 17\u2009years and 47% were male. Most (73%) were from black and minority ethnic groups, 64% gave a history of oral sex, 52% reported having a new sexual partner in the past 6\u2009months, 33% smoked cigarettes, 5.9% had concurrent genitourinary<jats:italic>Chlamydia trachomatis<\/jats:italic>infection and 1.5%<jats:italic>Neisseria gonorrhoeae<\/jats:italic>and 5.0% were gay or bisexual. Only 47% (50\/107) of females reported being vaccinated against HPV 16\/18, of whom 74% had received \u22652 injections. HPV genotyping showed three mouthwash samples (1.5%, 95% CI 0.3% to 4.3%) were positive for possible high-risk human papillomavirus (HR-HPV), one (0.5%, 0.0% to 2.7%) for low-risk HPV 6\/11, but none (0.0%, 0.0% to 1.8%) for HR-HPV. Four samples (2.0%, 0.5% to 5.0%) were positive for HPV16 using a HPV16 type-specific quantitative PCR, but these were at a very low copy number and considered essentially negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the high prevalence of oral sex and genitourinary chlamydia and low prevalence of HPV vaccination, the prevalence of oropharyngeal HR-HPV in these adolescents was negligible.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2020-054428","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T21:25:56Z","timestamp":1599168356000},"page":"458-460","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Human papillomavirus (HPV) vaccination and oropharyngeal HPV in ethnically diverse, sexually active adolescents: community-based cross-sectional study"],"prefix":"10.1136","volume":"97","author":[{"given":"Sarah","family":"Kerry-Barnard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Beddows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Beckley-Hoelscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Soldan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Panwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cangul","family":"Seran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Lesniewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Planche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Hay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2568-8211","authenticated-orcid":false,"given":"Pippa","family":"Oakeshott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"2024092104100709000_97.6.458.1","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(19)30227-2","article-title":"Early detection of HPV-associated oropharyngeal cancer","volume":"393","author":"Lechner","year":"2019","journal-title":"Lancet"},{"key":"2024092104100709000_97.6.458.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62035-8"},{"key":"2024092104100709000_97.6.458.3","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1177\/0956462417736432","article-title":"Sexually active students' acceptability of providing saline oral samples for future human papillomavirus testing","volume":"28","author":"Williamson","year":"2017","journal-title":"Int J STD AIDS"},{"key":"2024092104100709000_97.6.458.4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068329"},{"key":"2024092104100709000_97.6.458.5","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/infdis\/jiy715","article-title":"Might oral human papillomavirus (HPV) infection in healthy individuals explain differences in HPV-Attributable fractions in oropharyngeal cancer? A systematic review and meta-analysis","volume":"219","author":"Mena","year":"2019","journal-title":"J Infect Dis"},{"key":"2024092104100709000_97.6.458.6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165847","article-title":"Human papilloma virus (HPV) oral prevalence in Scotland (HOPSCOTCH): a feasibility study in dental settings","volume":"11","author":"Conway","year":"2016","journal-title":"PLoS One"},{"key":"2024092104100709000_97.6.458.7","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cmi.2018.10.019","article-title":"'Test N treat' (TnT): a cluster randomized feasibility trial of on-site rapid Chlamydia trachomatis tests and treatment in ethnically diverse, sexually active teenagers attending technical colleges","volume":"25","author":"Oakeshott","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"2024092104100709000_97.6.458.8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4168"},{"key":"2024092104100709000_97.6.458.9","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2014-051955"},{"key":"2024092104100709000_97.6.458.10","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.22167"},{"key":"2024092104100709000_97.6.458.11","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0682"},{"key":"2024092104100709000_97.6.458.12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-022497"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2020-054428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T11:10:50Z","timestamp":1726917050000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2020-054428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,3]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,8,17]]},"published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1136\/sextrans-2020-054428"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2020-054428","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,3]]}}}