{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:31:14Z","timestamp":1740133874435,"version":"3.37.3"},"reference-count":35,"publisher":"BMJ","funder":[{"DOI":"10.13039\/100013382","name":"Institute of Translational Health Sciences","doi-asserted-by":"publisher","award":["NCATS UL1 TR002319"],"award-info":[{"award-number":["NCATS UL1 TR002319"]}],"id":[{"id":"10.13039\/100013382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI110666","U19AI113173"],"award-info":[{"award-number":["AI110666","U19AI113173"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Bacterial vaginosis-associated bacterium 2 (BVAB2),<jats:italic>Mageeibacillus indolicus<\/jats:italic>and<jats:italic>Sneathia<\/jats:italic>spp are highly predictive of bacterial vaginosis (BV) in cisgender women. They have been associated with non-gonococcal urethritis (NGU) in cisgender men in some but not all populations. We evaluated this association in a cross-sectional study of cisgender men who have sex with women only (MSW).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MSW without gonorrhoea attending a sexual health clinic (SHC) from 2014 to 2018 completed a computer-assisted self-interview, clinical interview and examination. NGU was defined as \u22655 polymorphonuclear leucocytes\/high-power field in urethral exudates plus either urethral symptoms or visible discharge. Urine was tested for<jats:italic>Chlamydia trachomatis<\/jats:italic>and<jats:italic>Mycoplasma genitalium<\/jats:italic>using Aptima (Hologic) and for BVAB2,<jats:italic>M. indolicus<\/jats:italic>,<jats:italic>Sneathia<\/jats:italic>spp,<jats:italic>Trichomonas vaginalis<\/jats:italic>,<jats:italic>Ureaplasma urealyticum<\/jats:italic>,<jats:italic>Haemophilus influenzae<\/jats:italic>, herpes simplex virus and adenovirus using quantitative PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 317 MSW age 17\u201371, 67 (21.1%) had<jats:italic>Sneathia<\/jats:italic>spp, 36 (11.4%) had BVAB2, and 17 (5.4%) had<jats:italic>M. indolicus<\/jats:italic>at enrolment. Having \u22653 partners in the past 2 months was the only characteristic that was more common among MSW with than those without these bacteria (BVAB2: 47% vs 23%,<jats:italic>M. indolicus<\/jats:italic>: 53% vs 24%,<jats:italic>Sneathia<\/jats:italic>spp: 42% vs 22%; p\u22640.03 for all). One-hundred seventeen men (37%) were diagnosed with NGU at enrolment. There was no significant association of BVAB2,<jats:italic>M. indolicus<\/jats:italic>or<jats:italic>Sneathia<\/jats:italic>spp with NGU (adjusted OR=0.59, 95% CI 0.14 to 2.43; aOR=3.40, 95% CI 0.68 to 17.06; aOR=0.46, 95% CI 0.16 to 1.27). Of 109 MSW with monthly samples, 34 (31.2%) had one of the bacteria at one or more follow-up visits, 22 of which were co-colonised with &gt;1. Median persistence over 6 months did not differ significantly (BVAB2=30.5 days, IQR=28\u201387;<jats:italic>M. indolicus<\/jats:italic>=87 days, IQR=60\u2013126;<jats:italic>Sneathia<\/jats:italic>spp=70 days, IQR=30\u2013135; p\u22650.20 for each comparison).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neither BVAB2,<jats:italic>M. indolicus<\/jats:italic>nor<jats:italic>Sneathia<\/jats:italic>spp were associated with increased risk of prevalent NGU in MSW attending an SHC.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2022-055494","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T18:31:42Z","timestamp":1670351502000},"page":"sextrans-2022-055494","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Bacterial vaginosis-associated bacteria in cisgender men who have sex with women: prevalence, association with non-gonococcal urethritis and natural history"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3569-0641","authenticated-orcid":false,"given":"Kaitlin A","family":"Zinsli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-3859","authenticated-orcid":false,"given":"Sujatha","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-2523","authenticated-orcid":false,"given":"Jennifer E","family":"Balkus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-6578","authenticated-orcid":false,"given":"Laura C","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Sylvan","family":"Lowens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-1022","authenticated-orcid":false,"given":"Emily","family":"Rowlinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-1107","authenticated-orcid":false,"given":"Tashina S","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-6848","authenticated-orcid":false,"given":"Sarah S","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew M","family":"Munch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4896-7654","authenticated-orcid":false,"given":"Lisa E","family":"Manhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2735-6800","authenticated-orcid":false,"given":"David N","family":"Fredricks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"2022120610201994000_sextrans-2022-055494v1.1","unstructured":"Martin DH . Urethritis in Males. In: Holmes KK et al , ed. Sexually transmitted diseases. New York, NY: McGraw Hill, 2008: 1107\u201326."},{"key":"2022120610201994000_sextrans-2022-055494v1.2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000054"},{"key":"2022120610201994000_sextrans-2022-055494v1.3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1123"},{"key":"2022120610201994000_sextrans-2022-055494v1.4","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000573"},{"key":"2022120610201994000_sextrans-2022-055494v1.5","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir517"},{"key":"2022120610201994000_sextrans-2022-055494v1.6","doi-asserted-by":"publisher","DOI":"10.1086\/499434"},{"key":"2022120610201994000_sextrans-2022-055494v1.7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201380"},{"key":"2022120610201994000_sextrans-2022-055494v1.8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214425"},{"key":"2022120610201994000_sextrans-2022-055494v1.9","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e318074e565"},{"key":"2022120610201994000_sextrans-2022-055494v1.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043802"},{"key":"2022120610201994000_sextrans-2022-055494v1.11","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000318"},{"key":"2022120610201994000_sextrans-2022-055494v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.089"},{"key":"2022120610201994000_sextrans-2022-055494v1.13","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2011.049213"},{"key":"2022120610201994000_sextrans-2022-055494v1.14","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2018-053634"},{"key":"2022120610201994000_sextrans-2022-055494v1.15","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20365"},{"key":"2022120610201994000_sextrans-2022-055494v1.16","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00216-06"},{"key":"2022120610201994000_sextrans-2022-055494v1.17","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01384-08"},{"key":"2022120610201994000_sextrans-2022-055494v1.18","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001314"},{"key":"2022120610201994000_sextrans-2022-055494v1.19","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.4.4.485"},{"key":"2022120610201994000_sextrans-2022-055494v1.20","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6404a1"},{"key":"2022120610201994000_sextrans-2022-055494v1.21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037818"},{"key":"2022120610201994000_sextrans-2022-055494v1.22","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020419"},{"key":"2022120610201994000_sextrans-2022-055494v1.23","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02884-07"},{"key":"2022120610201994000_sextrans-2022-055494v1.24","unstructured":"Hillier SL MJ , Holmes KK . Bacterial vaginosis. In: Holmes KK , Sparling PF , Mardh PA , eds. Sexually transmitted diseases. New York, NY: McGraw Hill, 2008: 737\u201368."},{"key":"2022120610201994000_sextrans-2022-055494v1.25","first-page":"373","article-title":"An association between non-gonococcal urethritis and bacterial vaginosis and the implications for patients and their sexual partners","volume":"73","author":"Keane","year":"1997","journal-title":"Genitourin Med"},{"key":"2022120610201994000_sextrans-2022-055494v1.26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06581.x"},{"key":"2022120610201994000_sextrans-2022-055494v1.27","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03360080058029"},{"key":"2022120610201994000_sextrans-2022-055494v1.28","first-page":"163","article-title":"The effectiveness of single-dose metronidazole therapy for patients and their partners with bacterial vaginosis","volume":"28","author":"Mengel","year":"1989","journal-title":"J Fam Pract"},{"key":"2022120610201994000_sextrans-2022-055494v1.29","first-page":"267","article-title":"Treatment of male partners and recurrence of bacterial vaginosis: a randomised trial","volume":"73","author":"Colli","year":"1997","journal-title":"Genitourin Med"},{"key":"2022120610201994000_sextrans-2022-055494v1.30","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-02077-3"},{"key":"2022120610201994000_sextrans-2022-055494v1.31","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3182631d89"},{"key":"2022120610201994000_sextrans-2022-055494v1.32","first-page":"CD011701","article-title":"Antibiotic treatment for the sexual partners of women with bacterial vaginosis","volume":"10","author":"Amaya-Guio","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2022120610201994000_sextrans-2022-055494v1.33","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000175396.10304.62"},{"key":"2022120610201994000_sextrans-2022-055494v1.34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113771"},{"key":"2022120610201994000_sextrans-2022-055494v1.35","unstructured":"Zinsli KA , Manhart LE , Balkus JE . Non-Gonococcal Urethritis and Its Relationship to Three Novel Bacterial Vaginosis (BV) Associated Bacteria [Preprint]. 2020 https:\/\/www.proquest.com\/dissertations-theses\/non-gonococcal-urethritis-relationship-three\/docview\/2444855799\/se-2"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2022-055494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T18:31:51Z","timestamp":1670351511000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2022-055494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,6]]},"references-count":35,"alternative-id":["10.1136\/sextrans-2022-055494"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2022-055494","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"type":"print","value":"1368-4973"},{"type":"electronic","value":"1472-3263"}],"subject":[],"published":{"date-parts":[[2022,12,6]]}}}