{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:31:17Z","timestamp":1740133877944,"version":"3.37.3"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"abstract":"Objectives<\/jats:title>This study is reporting the CO2<\/jats:sub>laser treatment efficiency on urethral lesions caused by human papillomavirus (HPV) and the correlation between the type of lesion high-grade and low-grade on the histology and the HPV genotype(s).<\/jats:p><\/jats:sec>Methods<\/jats:title>Sixty-nine patients (59 men and 10\u2009women) with urethral lesions were screened for HPV genotype(s) by in situ hybridisation and PCR. HPV lesions were biopsied and p16INK4a<\/jats:sup>expression was tested to confirm urethral high-grade squamous intraepithelial lesions (U HSIL) on the histology prior to CO2<\/jats:sub>laser treatment under colposcopy. The patients were followed up for 12 months.<\/jats:p><\/jats:sec>Results<\/jats:title>We observed urethral low-grade squamous intraepithelial lesions (U LSIL) in 54\/69 cases (78.3%) and U HSIL in 7\/69 cases (10%) confirmed by p16INK4a staining<\/jats:sup>. Then we looked at the HPV genotype present in each lesion. We observed the following: 31\/69 (45%) patients have a unique HPV genotype, with 12\/31 (38.7%) of high risk; 21\/54 (38.8%) of U LSIL and 1\/7 (14%) of U HSIL have HPV low-risk and high-risk coinfections. Efficient treatment with CO2<\/jats:sub>laser under colposcopy was done using a meatal spreader to help visualisation of 20\u2009mm in the distal urethra. We cured 64\/69 (92.7%) patients at 3 months with 4\/69 (5.7%) meatotomy and persistent 1\/67 (1.4%) urethral stricture at 12 months.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HSIL was present in the urethra without being able to define specific clinical criteria. Treatment with a CO2<\/jats:sub>laser under colposcopy with a meatus spreader is a simple surgical procedure with high efficiency and few complications that could prevent the risk of HPV-induced carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2022-055503","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T17:38:48Z","timestamp":1680111528000},"page":"sextrans-2022-055503","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["High-grade and low-grade HPV-induced urethral lesions treated by CO2<\/sub>laser under colposcopy"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6750-3783","authenticated-orcid":false,"given":"Olivier","family":"Aynaud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"2023032910202732000_sextrans-2022-055503v1.1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1001\/jamaoncol.2016.6192","article-title":"Prevalence of genital human papillomavirus infection and human papillomavirus vaccination rates among US adult men","volume":"3","author":"Han","year":"2017","journal-title":"JAMA Oncol"},{"key":"2023032910202732000_sextrans-2022-055503v1.2","doi-asserted-by":"publisher","DOI":"10.1177\/095646249500600308"},{"key":"2023032910202732000_sextrans-2022-055503v1.3","doi-asserted-by":"publisher","DOI":"10.1086\/521629"},{"key":"2023032910202732000_sextrans-2022-055503v1.4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.humpath.2017.08.006","article-title":"Carcinoma of the urethra","volume":"72","author":"Zhang","year":"2018","journal-title":"Hum Pathol"},{"key":"2023032910202732000_sextrans-2022-055503v1.5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00104.x"},{"key":"2023032910202732000_sextrans-2022-055503v1.6","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1093\/clinids\/20.Supplement_1.S91","article-title":"Human papillomavirus infection and genital warts: update on epidemiology and treatment","volume":"20 Suppl 1","author":"Stone","year":"1995","journal-title":"Clin Infect Dis"},{"key":"2023032910202732000_sextrans-2022-055503v1.7","doi-asserted-by":"crossref","unstructured":"Aynaud O . Meatal spreader. J Urol 1992;147:409. doi:10.1016\/s0022-5347(17)37251-8","DOI":"10.1016\/S0022-5347(17)37251-8"},{"key":"2023032910202732000_sextrans-2022-055503v1.8","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31826916c7"},{"key":"2023032910202732000_sextrans-2022-055503v1.9","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"2023032910202732000_sextrans-2022-055503v1.10","doi-asserted-by":"publisher","DOI":"10.1086\/498164"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2022-055503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T17:38:53Z","timestamp":1680111533000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2022-055503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,29]]},"references-count":10,"alternative-id":["10.1136\/sextrans-2022-055503"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2022-055503","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"type":"print","value":"1368-4973"},{"type":"electronic","value":"1472-3263"}],"subject":[],"published":{"date-parts":[[2023,3,29]]}}}