{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:43:07Z","timestamp":1757778187486,"version":"3.37.3"},"reference-count":10,"publisher":"BMJ","issue":"6","funder":[{"DOI":"10.13039\/501100020363","name":"Institute for Information Industry, Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["112-2314-B-075A-006"],"award-info":[{"award-number":["112-2314-B-075A-006"]}],"id":[{"id":"10.13039\/501100020363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["PH-112-PP05"],"award-info":[{"award-number":["PH-112-PP05"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"crossref","award":["TCVGH-1123901C","TCVGH-1123901D","TCVGH-PU1128105"],"award-info":[{"award-number":["TCVGH-1123901C","TCVGH-1123901D","TCVGH-PU1128105"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2024,5,29]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The 2022 global outbreak of monkeypox virus (MPXV), previously confined to Central and West Africa, necessitates an enhanced understanding of its spread. Comprehensive genomic surveillance to understand the virus\u2019s evolution and spread is needed, particularly in Asia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genomic data from 169 MPXV genome sequences in Asia were analysed. Through advanced genomic sequencing of clinical samples, we analysed the distribution and mutations of MPXV lineages in Asia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Phylogenetic analysis revealed a distinct clustering of C.1 strains rise in Northeast Asia in 2023, while genomic examination identified specific consensus mutations like R84K, R665C and L16F in C.1 strains. The mutations, coupled with an increased rate of apolipoprotein B mRNA-editing catalytic polypeptide-like 3 motif G-to-A mutations in C.1 (OR 24.87\u00b18.81), indicate a potential adaptation mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings underscore the need for ongoing surveillance and provide vital insights into MPXV\u2019s evolving dynamics, aiding in public health strategy formulation against this emerging infectious threat.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2024-056119","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T17:21:27Z","timestamp":1719249687000},"page":"384-387","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Tracing the footprints of MPXV in Asia: phylogenetic insights and lineage dynamics"],"prefix":"10.1136","volume":"100","author":[{"given":"Yung-Chun","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chieh","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Chiao","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Kuang","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8006-4917","authenticated-orcid":false,"given":"Po-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"2024081910400986000_100.6.384.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00055-5"},{"key":"2024081910400986000_100.6.384.2","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1038\/s41591-023-02542-x","article-title":"Viral genetic clustering and transmission Dynamics of the 2022 Mpox outbreak in Portugal","volume":"29","author":"Borges","year":"2023","journal-title":"Nat Med"},{"key":"2024081910400986000_100.6.384.3","doi-asserted-by":"publisher","DOI":"10.3201\/eid2002.130118"},{"key":"2024081910400986000_100.6.384.4","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1038\/s41591-023-02456-8","article-title":"Distinct Monkeypox virus lineages Co-circulating in humans before 2022","volume":"29","author":"Ndodo","year":"2023","journal-title":"Nat Med"},{"key":"2024081910400986000_100.6.384.5","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.21105\/joss.03773","article-title":"Nextclade: clade assignment, Mutation calling and quality control for viral Genomes","volume":"6","author":"Aksamentov","year":"2021","journal-title":"JOSS"},{"key":"2024081910400986000_100.6.384.6","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.add4153","article-title":"Multiple lineages of Monkeypox virus detected in the United States, 2021-2022","volume":"378","author":"Gigante","year":"2022","journal-title":"Science"},{"key":"2024081910400986000_100.6.384.7","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.3390\/v7062757","article-title":"Apobec3 interference during replication of viral Genomes","volume":"7","author":"Willems","year":"2015","journal-title":"Viruses"},{"key":"2024081910400986000_100.6.384.8","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s41591-022-01907-y","article-title":"Phylogenomic characterization and signs of Microevolution in the 2022 multi-country outbreak of Monkeypox virus","volume":"28","author":"Isidro","year":"2022","journal-title":"Nat Med"},{"key":"2024081910400986000_100.6.384.9","doi-asserted-by":"crossref","first-page":"e1012","DOI":"10.1016\/S2214-109X(23)00198-5","article-title":"Description of the first global outbreak of Mpox: an analysis of global surveillance data","volume":"11","author":"Laurenson-Schafer","year":"2023","journal-title":"Lancet Glob Health"},{"key":"2024081910400986000_100.6.384.10","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.1038\/s41467-023-44092-3","article-title":"Phylogeny and molecular evolution of the first local Monkeypox virus cluster in Guangdong province, China","volume":"14","author":"Yu","year":"2023","journal-title":"Nat Commun"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2024-056119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T17:40:32Z","timestamp":1724089232000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2024-056119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,8,19]]},"published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1136\/sextrans-2024-056119"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2024-056119","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"type":"print","value":"1368-4973"},{"type":"electronic","value":"1472-3263"}],"subject":[],"published":{"date-parts":[[2024,6,24]]}}}