{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:09:48Z","timestamp":1792894188293,"version":"4.5.0"},"reference-count":25,"publisher":"BMJ","issue":"4","funder":[{"name":"Council for the AIDS Trust Fund","award":["MSS344R"],"award-info":[{"award-number":["MSS344R"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2024,12,2]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chemsex engagement is known to be associated with higher-risk sexual behaviour, HIV and sexually transmitted infection (STI). To reduce HIV infection risk, pre-exposure prophylaxis (PrEP) is increasingly used in the men who have sex with men (MSM) community. This study aims to examine the interrelationship between chemsex engagement and PrEP use in MSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross-sectional study with the recruitment of MSM in the community in Hong Kong. Participating MSM were invited to complete an online survey which included PrEP (experienced or na\u00efve) use, chemsex engagement history and HIV test results. Chemsex engagement referred to use of specific drugs (methamphetamine and\/or gamma-hydroxybutyrate) before and\/or during sex. Characteristics of MSM with and without history of chemsex engagement were examined in bivariable and multivariable logistic regression. In a case-control analysis with a 1:1 ratio of PrEP-na\u00efve and PrEP-experienced MSM, the association of chemsex engagement with history of PrEP use was examined in bivariable and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between February 2022 and January 2024, 338 eligible MSM were recruited. A higher proportion of MSM engaged in chemsex reported history of PrEP use and group sex. Prevalence of ever chemsex engagement was significantly higher in PrEP-experienced (29%) than PrEP-na\u00efve MSM (9%) (adjusted OR=2.69, 95% CI 1.28 to 5.67), after adjustment for confounders of age, history of STI testing, multiple sex partnership and inconsistent condom use. The history of chemsex engagement in the past 6 months was associated positively with ever and recent (6 months) use of PrEP. Five out of seven PrEP-na\u00efve MSM who had engaged in chemsex in the past 6\u2009months indicated their intention to take PrEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chemsex engagement was positively associated with PrEP use while most of the PrEP-na\u00efve MSM who had recently engaged in chemsex expressed interest to start PrEP. PrEP service could be an important community platform for chemsex intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/sextrans-2024-056331","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T13:20:34Z","timestamp":1736601634000},"page":"229-235","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Interrelationship between chemsex engagement and PrEP (pre-exposure prophylaxis) experience in men who have sex with men: a community-based cross-sectional study"],"prefix":"10.1136","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-8114","authenticated-orcid":false,"given":"Ngai Sze","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze Long","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystal Chi-Kei","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui-Shan","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"2025051910100620000_101.4.229.1","unstructured":"Public Health England . Substance Misuse Services for Men Involved in Chemsex. London: Public Health England, 2015."},{"key":"2025051910100620000_101.4.229.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2018.11.014"},{"key":"2025051910100620000_101.4.229.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2022.109741"},{"key":"2025051910100620000_101.4.229.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-020-01801-z"},{"key":"2025051910100620000_101.4.229.5","doi-asserted-by":"publisher","DOI":"10.1071\/SH17146"},{"key":"2025051910100620000_101.4.229.6","unstructured":"World Health Organization . Differentiated and simplified pre-exposure prophylaxis for hiv prevention: update to who implementation guidance. Tech Brief; 2022. Available: https:\/\/iris.who.int\/bitstream\/handle\/10665\/360861\/9789240053694-eng.pdf?sequence=1 [Accessed 17 Apr 2024]."},{"key":"2025051910100620000_101.4.229.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2019.10.015"},{"key":"2025051910100620000_101.4.229.8","doi-asserted-by":"crossref","unstructured":"de Sousa \u00c1FL , Nunes Ribeiro CJ , Santos G de S , et al . Intention to use PrEP among men who have sex with men and engage in chemsex: an international descriptive study. Ther Adv Infect Dis 2023;10. doi:10.1177\/20499361231206918","DOI":"10.1177\/20499361231206918"},{"key":"2025051910100620000_101.4.229.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108875"},{"key":"2025051910100620000_101.4.229.10","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2018-053933"},{"key":"2025051910100620000_101.4.229.11","doi-asserted-by":"crossref","DOI":"10.2196\/17894","article-title":"Influence of Social Media on Sexualized Drug Use and Chemsex Among Chinese Men Who Have Sex With Men: Observational Prospective Cohort Study","volume":"22","author":"Wang","year":"2020","journal-title":"J Med Internet Res"},{"key":"2025051910100620000_101.4.229.12","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-021-11056-5","article-title":"Delineating patterns of sexualized substance use and its association with sexual and mental health outcomes among young gay, bisexual and other men who have sex with men in Singapore: a latent class analysis","volume":"21","author":"Tan","year":"2021","journal-title":"BMC Public Health"},{"key":"2025051910100620000_101.4.229.13","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20010294","article-title":"Engagement in Chemsex among Men Who Have Sex with Men (MSM) in Malaysia: Prevalence and Associated Factors from an Online National Survey","volume":"20","author":"Maviglia","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"2025051910100620000_101.4.229.14","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-067261","article-title":"Characteristics of HIV pre-exposure prophylaxis users at first PrEP counselling visit: the CSL-PrEP cohort","volume":"12","author":"Nozza","year":"2022","journal-title":"BMJ Open"},{"key":"2025051910100620000_101.4.229.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1995.tb02199.x"},{"key":"2025051910100620000_101.4.229.16","first-page":"156","article-title":"Reliability and validity of the Severity of Dependence Scale in a Chinese sample of treatment-seeking ketamine users","volume":"24","author":"Tung","year":"2014","journal-title":"East Asian Arch Psychiatry"},{"key":"2025051910100620000_101.4.229.17","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmedr.2020.101074","article-title":"Sexual, addiction and mental health care needs among men who have sex with men practicing chemsex - a cross-sectional study in the Netherlands","volume":"18","author":"Evers","year":"2020","journal-title":"Prev Med Rep"},{"key":"2025051910100620000_101.4.229.18","doi-asserted-by":"crossref","DOI":"10.1002\/jia2.25883","article-title":"Increasing awareness of HIV pre-exposure prophylaxis (PrEP) and willingness to use HIV PrEP among men who have sex with men: a systematic review and meta-analysis of global data","volume":"25","author":"Sun","year":"2022","journal-title":"J Int AIDS Soc"},{"key":"2025051910100620000_101.4.229.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2021.103119"},{"key":"2025051910100620000_101.4.229.20","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph182413299","article-title":"Mental Health Symptoms Associated with Sexualized Drug Use (Chemsex) among Men Who Have Sex with Men: A Systematic Review","volume":"18","author":"\u00cdncera-Fern\u00e1ndez","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"2025051910100620000_101.4.229.21","doi-asserted-by":"publisher","DOI":"10.1108\/DAT-09-2018-0043"},{"key":"2025051910100620000_101.4.229.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.epidem.2019.02.001"},{"key":"2025051910100620000_101.4.229.23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-60790-0","article-title":"A multilayer temporal network model for STD spreading accounting for permanent and casual partners","volume":"10","author":"Vajdi","year":"2020","journal-title":"Sci Rep"},{"key":"2025051910100620000_101.4.229.24","unstructured":"Special Preventive Programme, Centre for Health Protection, Hong Kong SAR Government . HIV surveillance report-2021. Available: https:\/\/www.chp.gov.hk\/files\/pdf\/aids21.pdf"},{"key":"2025051910100620000_101.4.229.25","first-page":"100969","article-title":"Comparison of control and transmission of COVID-19 across epidemic waves in Hong Kong: an observational study","volume":"43","author":"Yang","year":"2024","journal-title":"Lancet Reg Health West Pac"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2024-056331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T22:01:59Z","timestamp":1747864919000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2024-056331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,11]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,5,19]]},"published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1136\/sextrans-2024-056331"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2024-056331","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,11]]}}}