{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:13:53Z","timestamp":1788484433172,"version":"build-2803163510"},"reference-count":9,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NHS National Services Scotland"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2025,2,3]]},"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Describe the clinical, phenotypic and genomic characteristics of ceftriaxone-resistant\n                      <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n                      from Scotland.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cases were identified in routine care from 2018 to 2024. Minimum inhibitory concentrations were determined for seven antimicrobial agents. Whole genome sequencing was performed with Illumina and Oxford Nanopore Technology instruments. A phylogeny containing global ceftriaxone-resistant genomes was generated with Parsnp. A collection of ST8780 genomes was also analysed to give further context using reference-based mapping with Snippy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were five cases of ceftriaxone-resistant\n                      <jats:italic>N. gonorrhoeae<\/jats:italic>\n                      detected. One case (multilocus sequencing typing (MLST) ST1903) clustered within the FC428 lineage in a returning traveller from an Asia-Pacific country. Two cases belonged to the recently described extensively drug-resistant MLST ST16406, a returning traveller from an Asia-Pacific country and a sexual contact within Scotland. The final two cases were a resident of an Asia-Pacific country and a sexual contact within Scotland, both belonged to MLST ST8780. These were distinct from other publicly available ST8780 genomes, suggesting a novel introduction of the mosaic\n                      <jats:italic>penA<\/jats:italic>\n                      -60.001 allele. All cases were initially treated with ceftriaxone-based regimes, four returned for test of cure and showed clearance of infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>As ceftriaxone resistance is increasingly identified, multiple public health interventions are required to reduce the impact of resistance on gonorrhoea treatment globally.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/sextrans-2024-056405","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T07:10:40Z","timestamp":1741331440000},"page":"534-537","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Investigation of ceftriaxone-resistant\n                    <i>Neisseria gonorrhoeae<\/i>\n                    detected in Scotland, 2018\u20132024"],"prefix":"10.1136","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0370-3700","authenticated-orcid":false,"given":"Martin P","family":"McHugh","sequence":"first","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"},{"name":"Edinburgh Medical School, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Aburajab","sequence":"additional","affiliation":[{"name":"NHS Forth Valley, Stirling, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Maxwell","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow and Clyde, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Anderson","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fraser","family":"Cairns","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seb","family":"Cotton","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"},{"name":"Edinburgh Medical School, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Gough","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Malloy","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Mathers","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Renwick","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Shepherd","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate E","family":"Templeton","sequence":"additional","affiliation":[{"name":"NHS Lothian, Edinburgh, UK"},{"name":"Edinburgh Medical School, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"2025111702300783000_101.8.534.1","unstructured":"WHO . WHO bacterial priority pathogens list, 2024: bacterial pathogens of public health importance to guide research, development and strategies to prevent and control antimicrobial resistance. Geneva, Switzerland World Health Organisation; 2024."},{"key":"2025111702300783000_101.8.534.2","doi-asserted-by":"crossref","first-page":"2300456","DOI":"10.2807\/1560-7917.ES.2023.28.37.2300456","article-title":"Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023","volume":"28","author":"Maubaret","year":"2023","journal-title":"Euro Surveill"},{"key":"2025111702300783000_101.8.534.3","doi-asserted-by":"crossref","first-page":"2200803","DOI":"10.2807\/1560-7917.ES.2022.27.46.2200803","article-title":"Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022","volume":"27","author":"Day","year":"2022","journal-title":"Euro Surveill"},{"key":"2025111702300783000_101.8.534.4","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad258"},{"key":"2025111702300783000_101.8.534.5","doi-asserted-by":"crossref","first-page":"2200455","DOI":"10.2807\/1560-7917.ES.2022.27.24.2200455","article-title":"Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022","volume":"27","author":"Pleininger","year":"2022","journal-title":"Euro Surveill"},{"key":"2025111702300783000_101.8.534.6","doi-asserted-by":"crossref","first-page":"2300125","DOI":"10.2807\/1560-7917.ES.2023.28.10.2300125","article-title":"Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022","volume":"28","author":"Golparian","year":"2023","journal-title":"Euro Surveill"},{"key":"2025111702300783000_101.8.534.7","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2018.23.27.1800323"},{"key":"2025111702300783000_101.8.534.8","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae063"},{"key":"2025111702300783000_101.8.534.9","doi-asserted-by":"crossref","unstructured":"Cam\u00e9l\u00e9na F , M\u00e9rim\u00e8che M , Brousseau J , et al . Emergence of Extensively Drug-Resistant Neisseria gonorrhoeae, France, 2023. Emerg Infect Dis 2024;30. doi:10.3201\/eid3009.240557","DOI":"10.3201\/eid3009.240557"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2024-056405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T10:30:30Z","timestamp":1763375430000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2024-056405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":9,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,11,17]]},"published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1136\/sextrans-2024-056405"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2024-056405","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.10.24.24315890","asserted-by":"object"}]},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]}}}