{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:44:06Z","timestamp":1777491846947,"version":"3.51.4"},"reference-count":9,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2025,7,7]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite high HIV prevalence rates among trans women (TW), few preventive interventions have targeted this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We described sociodemographic and clinical data from a cohort of TW followed up for pre-exposure prophylaxis (PrEP) at the Sexual Health Clinic of Bichat hospital in Paris between 2016 and 2023, via a multidisciplinary community-led PrEP programme.<\/jats:p>\n                    <jats:p>The total number of TW starting PrEP and having ongoing follow-up each year was assessed. We described retention in care at 3, 6 and 12 months and median time of follow-up. Incidence of PrEP discontinuation was calculated using Poisson regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between January 2016 and December 2023, 209 TW have been followed up for PrEP at Bichat Hospital, with a median age of 36 years and mostly originating from South America (79.4%, 166\/209). Seventy-four per cent of TW (155\/209) were sex workers and 53.6% (112\/209) had regular health insurance. Most of TW were on daily PrEP (94.3 %, 197\/209).<\/jats:p>\n                    <jats:p>The total number of TW followed-up for PrEP per year increased from 17 in 2016 to 129 in 2023. Median time of follow-up was 10.3 months and incidence of PrEP discontinuations was 58.2 (CI 95% 49.51 to 68.57) per 100 persons-year. Retention in care at 6 and 12 months was, respectively, 62% and 38% for users who started PrEP in 2016 and 81% and 31% for those who started in 2022. Seven per cent of TW (13\/190) experienced adverse events, leading to PrEP discontinuation in 10\/190 cases. Two cases of HIV seroconversion were reported, both in TW who had stopped PrEP for gastrointestinal intolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our multidisciplinary reach-out community-led PrEP programme has increased PrEP access among our cohort of TW. Rates of retention in such a prevention programme of care remained poor. More interventions are needed to analyse PrEP barriers and improve retention in care for this specific population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/sextrans-2024-056445","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T17:20:43Z","timestamp":1754414443000},"page":"94-96","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Pre-exposure prophylaxis (PrEP) uptake and retention in care in a group of transgender women at high risk of HIV: a French cohort of follow-up"],"prefix":"10.1136","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0981-5041","authenticated-orcid":false,"given":"Valentina","family":"Isernia","sequence":"first","affiliation":[{"name":"Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minerva","family":"Cervantes","sequence":"additional","affiliation":[{"name":"Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Digumber","sequence":"additional","affiliation":[{"name":"Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"},{"name":"COREVIH IDF Nord, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frezzia","family":"Peralta","sequence":"additional","affiliation":[{"name":"Acceptess-T, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Louni","sequence":"additional","affiliation":[{"name":"COREVIH IDF Nord, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Deprez","sequence":"additional","affiliation":[{"name":"Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Le Gac","sequence":"additional","affiliation":[{"name":"Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"},{"name":"COREVIH IDF Nord, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Vandendriessche","sequence":"additional","affiliation":[{"name":"Acceptess-T, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Champenois","sequence":"additional","affiliation":[{"name":"INSERM, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelie","family":"Sautereau","sequence":"additional","affiliation":[{"name":"Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Bachelard","sequence":"additional","affiliation":[{"name":"Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao","family":"Phung","sequence":"additional","affiliation":[{"name":"Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A\u00efda","family":"Benalycherif","sequence":"additional","affiliation":[{"name":"IMEA, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Landman","sequence":"additional","affiliation":[{"name":"Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"},{"name":"IMEA, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Blanquart","sequence":"additional","affiliation":[{"name":"Acceptess-T, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0274-5199","authenticated-orcid":false,"given":"Jade","family":"Ghosn","sequence":"additional","affiliation":[{"name":"Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"},{"name":"INSERM, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"2026021702100697000_102.2.94.1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260063","article-title":"The worldwide burden of HIV in transgender individuals: An updated systematic review and meta-analysis","volume":"16","author":"Stutterheim","year":"2021","journal-title":"PLoS One"},{"key":"2026021702100697000_102.2.94.2","unstructured":"Sant\u00e9 publique France . Surveillance Du VIH et Des IST Bact\u00e9riennes En France En 2023. Saint-Maurice: Sant\u00e9 publique France, 2024:35."},{"key":"2026021702100697000_102.2.94.3","doi-asserted-by":"publisher","DOI":"10.1080\/17441692.2016.1154085"},{"key":"2026021702100697000_102.2.94.4","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002808"},{"key":"2026021702100697000_102.2.94.5","doi-asserted-by":"crossref","DOI":"10.1002\/jia2.25896","article-title":"Low PrEP adherence despite high retention among transgender women in Brazil: the PrEParadas study","volume":"25","author":"Jalil","year":"2022","journal-title":"J Int AIDS Soc"},{"key":"2026021702100697000_102.2.94.6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3390\/ijerph21020133","article-title":"Determinants of HIV Pre-Exposure Prophylaxis (PrEP) Retention among Transgender Women: A Sequential, Explanatory Mixed Methods Study","volume":"21","author":"Andrzejewski","year":"2024","journal-title":"Int J Environ Res Public Health"},{"key":"2026021702100697000_102.2.94.7","doi-asserted-by":"crossref","first-page":"e512","DOI":"10.1016\/S2352-3018(15)00206-4","article-title":"HIV pre-exposure prophylaxis in transgender women: a subgroup analysis of the iPrEx trial","volume":"2","author":"Deutsch","year":"2015","journal-title":"Lancet HIV"},{"key":"2026021702100697000_102.2.94.8","doi-asserted-by":"crossref","first-page":"e554","DOI":"10.1016\/S2352-3018(22)00133-3","article-title":"Daily and on-demand HIV pre-exposure prophylaxis with emtricitabine and tenofovir disoproxil (ANRS PREVENIR): a prospective observational cohort study","volume":"9","author":"Molina","year":"2022","journal-title":"Lancet HIV"},{"key":"2026021702100697000_102.2.94.9","doi-asserted-by":"publisher","DOI":"10.1071\/SH18065"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2024-056445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T10:10:23Z","timestamp":1771323023000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2024-056445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,5]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,17]]},"published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1136\/sextrans-2024-056445"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2024-056445","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,5]]}}}