{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T22:39:05Z","timestamp":1775515145039,"version":"3.50.1"},"reference-count":30,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2025,1,18]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Doxycycline prophylaxis shows promise for bacterial sexually transmitted infection (STI) prevention, but data primarily come from high-income countries. This study assessed awareness, willingness and factors associated with willingness to use doxycycline for bacterial STI prevention among men who have sex with men (MSM) using HIV pre-exposure prophylaxis (HIV-PrEP) in Vietnam.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between 25 January and 4 February 2024, a cross-sectional study recruited males aged \u226518 years who reported having sex with men in the past 12 months from 11 HIV-PrEP clinics in Hanoi and Ho Chi Minh City. Self-administered surveys were conducted, and multivariable logistic regression was applied to identify factors associated with willingness to use doxycycline prophylaxis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 350 participants, the median age was 25 (IQR 21\u201330), and 10.6% self-reported a bacterial STI diagnosis in the past 12 months. In the previous 6 months, the median number of sex partners was 2 (IQR 1\u20134), 53.1% reported condomless anal sex. Awareness of doxycycline was low (20.2%; 65\/322); however, 75.4% (264\/350) expressed willingness to use it, with 63.6% (168\/264) preferring doxyPrEP. Participants who disclosed HIV-PrEP use to all sex partners (adjusted OR (aOR) 4.17; 95% CI 1.84, 9.46) and those with higher perceived STI risk (aOR 1.12; 95% CI 1.03, 1.22) were more likely to report willingness to use doxycycline prophylaxis. Concerns about daily medication (aOR 0.43; 95% CI 0.24, 0.81) and fear of judgement from peers (aOR 0.41; 95% CI 0.21, 0.81) were associated with lower willingness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Knowledge of doxycycline prophylaxis among MSM on HIV-PrEP in Vietnam was low. However, most expressed willingness to use it, with two-thirds preferring doxyPrEP. Findings highlight the need to disseminate information on doxycycline prophylaxis for bacterial STI prevention, monitoring the usage and evaluating comparative effectiveness of doxyPEP and doxyPrEP to guide implementation efforts in Vietnam.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/sextrans-2024-056449","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T13:21:05Z","timestamp":1738848065000},"page":"367-373","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Doxycycline prophylaxis for bacterial sexually transmitted infection prevention in Vietnam: awareness, attitudes and willingness to use among men who have sex with men using HIV-PrEP"],"prefix":"10.1136","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-8091","authenticated-orcid":false,"given":"Hao T M","family":"Bui","sequence":"first","affiliation":[{"name":"Center for Training and Research on Substance Abuse - HIV, Hanoi Medical University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-6458","authenticated-orcid":false,"given":"Paul C","family":"Adamson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D","family":"Klausner","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giang M.","family":"Le","sequence":"additional","affiliation":[{"name":"Center for Training and Research on Substance Abuse - HIV, School of Preventive Medicine and Public Healthon HIV, Hanoi Medical University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamina M","family":"Gorbach","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"2025082809551086000_101.6.367.1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanepe.2023.100742","article-title":"Epidemiology and determinants of reemerging bacterial sexually transmitted infections (STIs) and emerging STIs in Europe","volume":"34","author":"Mitj\u00e0","year":"2023","journal-title":"Lancet Reg Health Eur"},{"key":"2025082809551086000_101.6.367.2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001626"},{"key":"2025082809551086000_101.6.367.3","unstructured":"Bui H , Adamson PC , Nguyen TC , et al . Neisseria gonorrhoeae and chlamydia trachomatis positivity by symptom status and anatomic site of infection among men who have sex with men in a human immunodeficiency virus pre-exposure prophylaxis program in hanoi, vietnam. STI & HIV 2023 World Congress; 2023, Chicago, IL USA."},{"key":"2025082809551086000_101.6.367.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211934"},{"key":"2025082809551086000_101.6.367.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00236-6"},{"key":"2025082809551086000_101.6.367.6","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000216"},{"key":"2025082809551086000_101.6.367.7","unstructured":"Grennan T , Hull M , Mohammed S , et al . Daily doxycycline in msm on prep for prevention of sexually transmitted infections. Conference on Retroviruses and Opportunistic Infections, Virtual; 2021."},{"key":"2025082809551086000_101.6.367.8","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx420"},{"key":"2025082809551086000_101.6.367.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304007"},{"key":"2025082809551086000_101.6.367.10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/OLQ.0000000000001865","article-title":"Safety of Longer-Term Doxycycline Use: A Systematic Review and Meta-Analysis With Implications for Bacterial Sexually Transmitted Infection Chemoprophylaxis","volume":"50","author":"Chan","year":"2023","journal-title":"Sex Transm Dis"},{"key":"2025082809551086000_101.6.367.11","unstructured":"European AIDS Clinical Society (EACS) . EACS European AIDS clinical society guidelines, version 12.0. Available: https:\/\/www.eacsociety.org\/media\/guidelines-12.0.pdf [Accessed 6 Nov 2023]."},{"key":"2025082809551086000_101.6.367.12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.22246"},{"key":"2025082809551086000_101.6.367.13","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52258"},{"key":"2025082809551086000_101.6.367.14","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2022-055425"},{"key":"2025082809551086000_101.6.367.15","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2024.2356337"},{"key":"2025082809551086000_101.6.367.16","unstructured":"Vietnam Authority of HIV\/AIDS Prevention and Control . Annual meeting on HIV prevention and control progress and archievement in Vietnam. Available: https:\/\/vaac.gov.vn\/cuc-phong-chong-hiv-aids-to-chuc-hoi-nghi-tong-ket-cong-tac-phong-chong-hiv-nam-2023.html [Accessed 6 Nov 2023]."},{"key":"2025082809551086000_101.6.367.17","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001731"},{"key":"2025082809551086000_101.6.367.18","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001395"},{"key":"2025082809551086000_101.6.367.19","doi-asserted-by":"publisher","DOI":"10.1080\/09540129848307"},{"key":"2025082809551086000_101.6.367.20","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000647"},{"key":"2025082809551086000_101.6.367.21","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-022-14323-1","article-title":"Awareness and willingness to accept syphilis chemoprophylaxis among men who have sex with men from three cities in China: a cross-sectional study","volume":"22","author":"Zhang","year":"2022","journal-title":"BMC Public Health"},{"key":"2025082809551086000_101.6.367.22","doi-asserted-by":"crossref","unstructured":"Carveth-Johnson T , Stingone C , Nwokolo N , et al . Doxycycline use in MSM taking PrEP. Lancet HIV 2018;5. doi:10.1016\/S2352-3018(18)30210-8","DOI":"10.1016\/S2352-3018(18)30210-8"},{"key":"2025082809551086000_101.6.367.23","doi-asserted-by":"crossref","first-page":"e568","DOI":"10.1016\/S2352-3018(19)30186-9","article-title":"Use of doxycycline prophylaxis among gay and bisexual men in Melbourne","volume":"6","author":"Chow","year":"2019","journal-title":"Lancet HIV"},{"key":"2025082809551086000_101.6.367.24","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2019-054325"},{"key":"2025082809551086000_101.6.367.25","doi-asserted-by":"crossref","unstructured":"Hazra A , McNulty MC , Pyra M , et al . Filling in the Gaps: Updates on Doxycycline Prophylaxis for Bacterial Sexually Transmitted Infections. Clin Infect Dis 2024. doi:10.1093\/cid\/ciae062","DOI":"10.1093\/cid\/ciae062"},{"key":"2025082809551086000_101.6.367.26","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-020-05532-3","article-title":"Trends in antimicrobial resistance in Neisseria gonorrhoeae in Hanoi, Vietnam, 2017-2019","volume":"20","author":"Adamson","year":"2020","journal-title":"BMC Infect Dis"},{"key":"2025082809551086000_101.6.367.27","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/OLQ.0000000000001810","article-title":"Doxycycline Postexposure Prophylaxis Could Induce Cross-Resistance to Other Classes of Antimicrobials in Neisseria gonorrhoeae\u202f: An In Silico Analysis","volume":"50","author":"Vanbaelen","year":"2023","journal-title":"Sex Transm Dis"},{"key":"2025082809551086000_101.6.367.28","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00359-6"},{"key":"2025082809551086000_101.6.367.29","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00230-5"},{"key":"2025082809551086000_101.6.367.30","doi-asserted-by":"publisher","DOI":"10.1080\/13691058.2016.1269203"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2024-056449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:03:35Z","timestamp":1759928615000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2024-056449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,8,28]]},"published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1136\/sextrans-2024-056449"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2024-056449","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]}}}