{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:55:10Z","timestamp":1785531310949,"version":"3.56.0"},"reference-count":13,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC111-2629-B-006-003-MY2"],"award-info":[{"award-number":["NSTC111-2629-B-006-003-MY2"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2025,4,13]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Lymphogranuloma venereum (LGV) caused by\n                      <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                      genotypes L1\u2013L3 has been resurging among men who have sex with men (MSM) and people with HIV (PWH) in Western countries. While historically attributed to tropical regions, rectal LGV has been rarely recognised in Asia, with Taiwan recently becoming the second Asian country to report cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A multicentre, laboratory-based surveillance was conducted from January 2020 to December 2023 in Taiwan. Specimens were collected from MSM through syndromic testing and screening of high-risk populations.\n                      <jats:italic>C. trachomatis<\/jats:italic>\n                      was identified using commercial multiplex PCR assays, with genotyping performed through\n                      <jats:italic>ompA<\/jats:italic>\n                      gene sequencing. LGV-positive samples underwent multilocus sequence typing (MLST) following established protocols.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 446\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>trachomatis<\/jats:italic>\n                      -positive samples, 391 (87.7%) underwent successful\n                      <jats:italic>ompA<\/jats:italic>\n                      sequencing. Genovariant L2b accounted for 9.7% of cases, predominantly among PWH with rectal chlamydia (18.2%). PWH accounted for 85.7% of all genovariant L2b cases. Of 38 genovariant L2b samples from 35 cases, 34 (84.2%) samples completed MLST, revealing sequence type (ST) 53 as the predominant strain (74%). ST39 and ST63 were identified as unreported STs in Western countries, along with previously reported ST58. The four identified STs formed a cluster.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings indicate the clonal spread of\n                      <jats:italic>C. trachomatis<\/jats:italic>\n                      L2b-ST53 among MSM in Taiwan, primarily affecting PWH. The predominance of ST53 suggests potential international and domestic spread, indicative of the need for enhanced surveillance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/sextrans-2024-056477","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T13:20:31Z","timestamp":1745500831000},"page":"97-99","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Chlamydia trachomatis<\/i>\n                    genovariant L2b in men who have sex with men in Taiwan, 2020\u20132023"],"prefix":"10.1136","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9391-1561","authenticated-orcid":false,"given":"Chin-Shiang","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Yang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences, National Cheng Kung University, College of Medicine, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hsi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Jou","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Infection Control Room, Min Sheng General Hospital, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Ying","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-0836","authenticated-orcid":false,"given":"Chien-Ching","family":"Hung","sequence":"additional","affiliation":[{"name":"Departmentof Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"2026021702100699000_102.2.97.1","doi-asserted-by":"publisher","DOI":"10.1086\/423966"},{"key":"2026021702100699000_102.2.97.2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000519"},{"key":"2026021702100699000_102.2.97.3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab067"},{"key":"2026021702100699000_102.2.97.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2023.01.007"},{"key":"2026021702100699000_102.2.97.5","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.3201\/eid3010.240852","article-title":"Clustering of Polymorphic Membrane Protein E Clade in Chlamydia trachomatis Lineages from Men Who Have Sex with Men","volume":"30","author":"Mitobe","year":"2024","journal-title":"Emerg Infect 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