{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:40:42Z","timestamp":1760701242729,"version":"build-2065373602"},"reference-count":27,"publisher":"BMJ","funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW009343","K01TW012170"],"award-info":[{"award-number":["D43TW009343","K01TW012170"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Global Health Program at the David Geffen School of Medicine at UCLA"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2025,9,30]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Syphilis infections are high among men who have sex with men (MSM) on HIV pre-exposure prophylaxis (PrEP). Point-of-care (POC) testing may improve diagnosis and treatment. We performed a field evaluation of the Chembio dual path platform (DPP) Syphilis Screen and Confirm treponemal\/non-treponemal POC test within an HIV PrEP programme in Hanoi, Vietnam.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From December 2023 to July 2024, males aged \u226516 years enrolled in the HIV PrEP programme who reported sex with men in the last year were enrolled. Specimens were tested using the Chembio DPP syphilis screen and confirm test and reference treponemal (Abbott Bioline or Determine) and non-treponemal (rapid plasma reagin (RPR)) tests. Positive per cent agreement (PPA), negative per cent agreement (NPA), positive predictive value (PPV), negative predictive value (NPV) and Cohen\u2019s kappa were calculated comparing the DPP versus reference tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We enrolled 400 participants; median age was 26.4 years (IQR 22.5\u201330.4); one invalid test was excluded. The prevalence of a reactive treponemal test was 35.3% (141\/399). For the DPP treponemal test, PPA was 75.2% (95% CI 67.2% to 82.2%), NPA was 96.9% (95% CI 94% to 98.7%), PPV was 93% (95% CI 86.8% to 96.4%), NPV was 87.7% (95% CI 83.4% to 91%), and Cohen\u2019s kappa was 0.75. For the DPP non-treponemal test, PPA was 36.5% (95% CI 23.6% to 51%), NPA was 99.4% (95% CI 97.9% to 99.9%), PPV was 90.5% (95% CI 71.1% to 97.4%), NPV was 91.3% (95% CI 88% to 93.7%), and Cohen\u2019s kappa was 0.48 (95% CI 0.33 to 0.61). For RPR titres \u22651:8, PPA and Cohen\u2019s kappa increased to 85.7% (95% CI 57.2% to 98.2%) and 0.67 (95% CI 0.47 to 0.81), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among MSM in an HIV PrEP programme with high syphilis prevalence, the DPP treponemal test performed well. While non-treponemal performance was lower, it was strong for RPR titres \u22651:8, suggesting it could aid in identifying high-titre syphilis infections more likely to be transmissible.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/sextrans-2025-056652","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:10:28Z","timestamp":1760699428000},"page":"sextrans-2025-056652","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Field evaluation of a dual treponemal\/non-treponemal point-of-care test for syphilis within an HIV pre-exposure prophylaxis programme in Hanoi, Vietnam"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-2675","authenticated-orcid":false,"given":"Ursula","family":"Biba","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine, University of California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-8091","authenticated-orcid":false,"given":"Hao T M","family":"Bui","sequence":"additional","affiliation":[{"name":"Center for Training and Research on Substance Abuse-HIV, Hanoi Medical University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linh TP","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Training and Research on Substance Abuse-HIV, Hanoi Medical University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huong T","family":"Dang","sequence":"additional","affiliation":[{"name":"Center for Training and Research on Substance Abuse-HIV, Hanoi Medical University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh T","family":"Bui","sequence":"additional","affiliation":[{"name":"Center for Training and Research on Substance Abuse-HIV, Hanoi Medical University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh C","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Training and Research on Substance Abuse-HIV, Hanoi Medical University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen S","family":"Dau","sequence":"additional","affiliation":[{"name":"Center for Training and Research on Substance Abuse-HIV, Hanoi Medical University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loc Q","family":"Pham","sequence":"additional","affiliation":[{"name":"Center for Training and Research on Substance Abuse-HIV, Hanoi Medical University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Minh","family":"Giang","sequence":"additional","affiliation":[{"name":"Center for Training and Research on Substance Abuse-HIV, Hanoi Medical University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-6458","authenticated-orcid":false,"given":"Paul C","family":"Adamson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"2025101704101960000_sextrans-2025-056652v1.1","unstructured":"Implementing the global health sector strategies on HIV, viral hepatitis and sexually transmitted infections, 2022\u20132030: report on progress and gaps 2024. 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HIV\/sti integrated biological and behavioral surveillance (IBBS) in vietnam - results from round iii and trends across three rounds. 2005."},{"key":"2025101704101960000_sextrans-2025-056652v1.13","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-025-10679-y","article-title":"Clinical characteristics and treatment outcomes of opportunistic infections in advanced HIV disease patients among men who have sex with men in Vietnam: A prospective cross-sectional study","volume":"25","author":"Vo","year":"2025","journal-title":"BMC Infect Dis"},{"key":"2025101704101960000_sextrans-2025-056652v1.14","doi-asserted-by":"crossref","first-page":"e1196","DOI":"10.1016\/S2214-109X(18)30386-3","article-title":"High-quality health systems in the Sustainable Development Goals era: time for a revolution","volume":"6","author":"Kruk","year":"2018","journal-title":"Lancet Glob Health"},{"key":"2025101704101960000_sextrans-2025-056652v1.15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/0956462418802685","article-title":"A field evaluation of a rapid dual immunoassay for human immunodeficiency virus and syphilis antibodies, Hanoi, Vietnam","volume":"30","author":"Withers","year":"2019","journal-title":"Int J STD AIDS"},{"key":"2025101704101960000_sextrans-2025-056652v1.16","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02642-21","article-title":"Laboratory Evaluation of the DPP Syphilis Screen & Confirm Assay","volume":"10","author":"Vargas","year":"2022","journal-title":"Microbiol Spectr"},{"key":"2025101704101960000_sextrans-2025-056652v1.17","unstructured":"Point-of-care tests for sexually transmitted infections: target product profiles. Geneva World Health Organization; 2023."},{"key":"2025101704101960000_sextrans-2025-056652v1.18","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2016-053065"},{"key":"2025101704101960000_sextrans-2025-056652v1.19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ243"},{"key":"2025101704101960000_sextrans-2025-056652v1.20","unstructured":"Chembio Diagnostics, Inc . DPP syphilis screen & confirm Europe. 2025. Available: https:\/\/chembio.com\/products\/dpp-syphilis-screen-confirm-europe\/"},{"key":"2025101704101960000_sextrans-2025-056652v1.21","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"2025101704101960000_sextrans-2025-056652v1.22","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw348"},{"key":"2025101704101960000_sextrans-2025-056652v1.23","doi-asserted-by":"crossref","unstructured":"Allan-Blitz LT , Klausner JD . How To Use Rapid Dual Treponemal and Lipoidal Tests in Clinical Practice. Sex Transm Dis 2025. doi:10.1097\/OLQ.0000000000002176","DOI":"10.1097\/OLQ.0000000000002176"},{"key":"2025101704101960000_sextrans-2025-056652v1.24","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.cmi.2023.06.013","article-title":"Rapid diagnostic testing for syphilis in Arctic communities (the STAR study): a multisite prospective field diagnostic accuracy study in an intended-use setting","volume":"29","author":"Caya","year":"2023","journal-title":"Clin Microbiol Infect"},{"key":"2025101704101960000_sextrans-2025-056652v1.25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/0956462416642340","article-title":"Attributes of diagnostic tests to increase uptake of dual testing for syphilis and HIV in Port-au-Prince, Haiti","volume":"28","author":"Bristow","year":"2017","journal-title":"Int J STD AIDS"},{"key":"2025101704101960000_sextrans-2025-056652v1.26","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-13-1236","article-title":"\u201cNever testing for HIV\u201d among men who have sex with men in Viet Nam: results from an Internet-based cross-sectional survey","volume":"13","author":"Garc\u00eda","year":"2013","journal-title":"BMC Public Health"},{"key":"2025101704101960000_sextrans-2025-056652v1.27","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0118-RA"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2025-056652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:10:33Z","timestamp":1760699433000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2025-056652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":27,"alternative-id":["10.1136\/sextrans-2025-056652"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2025-056652","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]}}}