{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:57:35Z","timestamp":1793275055437,"version":"4.5.0"},"reference-count":50,"publisher":"BMJ","issue":"5","funder":[{"name":"Gilead"},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009060","name":"Sidaction","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2025,10,6]]},"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Despite the wide implementation of HIV oral pre-exposure prophylaxis (oPrEP), uptake, adherence and persistence issues remain. Long-acting injectable cabotegravir (CAB-LA) is a promising new PrEP HIV prevention option. However, little is known about oPrEP users\u2019 interest in it. We investigated men who have sex with men (MSM) oPrEP users\u2019 willingness to participate (WtP) in a CAB-LA PrEP study in France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We designed a cross-sectional questionnaire (\u2018NewPrEP\u2019) to evaluate attitudes to CAB-LA of daily and event-driven oPrEP users participating in the ANRS-PREVENIR cohort study (2017\u20132025). The outcome, WtP, was dichotomised into \u2018Willing\u2019 (absolutely\/probably) or \u2018Unwilling\u2019 (probably not\/absolutely not\/I would like to discuss this with my doctor before making a decision). We used multivariate logistic Bayesian model averaging to estimate factors associated with WtP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 1555 MSM followed in ANRS-PREVENIR in February 2023 with baseline data, 879 (57%) answered the NewPrEP questionnaire. Median age and follow-up time were 38 and 4.7 years, respectively; 37% and 22% were on daily- and event-driven oPrEP, respectively; 41% used a combination of both regimens. 64% had heard of CAB-LA PrEP, and 43% were WtP in a related study. Multivariate results showed that willing participants were younger and more likely to have heard of CAB-LA, to use daily oPrEP exclusively or in combination, to find it difficult to adhere to their regimen, to engage in chemsex, to trust their doctor and to be more interested in PrEP effectiveness than in the administration mode. They were less likely to perceive the obligatory 2-monthly hospital visits for CAB-LA PrEP as constraining, to be scared of injections and to fear long-acting medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WtP in a CAB-LA study among MSM oPREP users was moderate but concentrated among those with the greatest need. This highlights the need to enable free distribution. Future studies should evaluate adherence and retention in long-acting iPrEP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/sextrans-2025-056662","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:05:25Z","timestamp":1761289525000},"page":"284-291","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Willingness to participate in a long-acting injectable cabotegravir HIV pre-exposure prophylaxis study among men who have sex with men in the French ANRS-PREVENIR cohort"],"prefix":"10.1136","volume":"102","clinical-trial-number":[{"clinical-trial-number":"nct03113123","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"August","family":"Eubanks","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, ISSPAM, Marseille, France"},{"name":"Coalition Plus, Community-based research laboratory, Pantin, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Hoyer","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, ISSPAM, Marseille, France"},{"name":"Coalition Plus, Community-based research laboratory, Pantin, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdourahmane","family":"Sow","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, ISSPAM, Marseille, France"},{"name":"Coalition Plus, Community-based research laboratory, Pantin, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Mora","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, ISSPAM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambert","family":"Assoumou","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Beniguel","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0274-5199","authenticated-orcid":false,"given":"Jade","family":"Ghosn","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Universit\u00e9 Paris Cit\u00e9, Paris, France; Assistance Publique \u2013 H\u00f4pitaux de Paris. Nord, Department of Infectious Diseases, Hopital Bichat Claude Bernard and INSERM UMR 1137 IAME, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Camilo","family":"Jones","sequence":"additional","affiliation":[{"name":"AIDES, Pantin, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Costagliola","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Spire","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, ISSPAM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Molina","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9; D\u00e9partement de Maladies Infectieuses et Laboratoires de Virologie et de Pharmacologie, H\u00f4pitaux Saint-Louis, Lariboisi\u00e8re, Assistance Publique H\u00f4pitaux de Paris; INSERM UMR 944, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffroy","family":"Liegeon","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Global Health, Chicago Center for HIV Elimination, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-6596","authenticated-orcid":false,"given":"Luis","family":"Sagaon-Teyssier","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, ISSPAM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-9617","authenticated-orcid":false,"given":"Christel","family":"Proti\u00e8re","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, ISSPAM, Marseille, France"},{"name":"Research on Healthcare Performance-RESHAPE, Inserm U1290, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"2026071602100845000_102.5.284.1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1097\/QAD.0000000000000647","article-title":"Defining success with HIV pre-exposure prophylaxis: A prevention-effective adherence paradigm","volume":"29","author":"Haberer","year":"2015","journal-title":"AIDS Lond Engl"},{"key":"2026071602100845000_102.5.284.2","doi-asserted-by":"crossref","first-page":"e402","DOI":"10.1016\/S2352-3018(17)30089-9","article-title":"Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study","volume":"4","author":"Molina","year":"2017","journal-title":"Lancet HIV"},{"key":"2026071602100845000_102.5.284.3","doi-asserted-by":"crossref","first-page":"e554","DOI":"10.1016\/S2352-3018(22)00133-3","article-title":"Daily and on-demand HIV pre-exposure prophylaxis with emtricitabine and tenofovir disoproxil (ANRS PREVENIR): a prospective observational cohort study","volume":"9","author":"Molina","year":"2022","journal-title":"Lancet HIV"},{"key":"2026071602100845000_102.5.284.4","doi-asserted-by":"crossref","first-page":"e529","DOI":"10.1016\/S2468-2667(22)00106-2","article-title":"Real-world effectiveness of pre-exposure prophylaxis in men at high risk of HIV infection in France: a nested case-control study","volume":"7","author":"Jourdain","year":"2022","journal-title":"Lancet Public Health"},{"key":"2026071602100845000_102.5.284.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2101016"},{"key":"2026071602100845000_102.5.284.6","unstructured":"FDA . FDA approves first injectable treatment for hiv pre-exposure prevention. 2021. Available: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-injectable-treatment-hiv-pre-exposure-prevention [Accessed 03 Jul 2022]."},{"key":"2026071602100845000_102.5.284.7","unstructured":"World Health Organization . Guidelines on long-acting injectable cabotegravir for HIV prevention. Available: https:\/\/www.who.int\/publications-detail-redirect\/9789240054097 [Accessed 16 Oct 2023]."},{"key":"2026071602100845000_102.5.284.8","unstructured":"Eckford C . European Commission approves long-acting HIV drug option. Eur Pharm Rev 2023. 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