{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:02:40Z","timestamp":1776351760689,"version":"3.51.2"},"reference-count":5,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2025,12,9]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Syphilis is a sexually transmitted infection caused by\n                    <jats:italic>Treponema pallidum<\/jats:italic>\n                    . It progresses through three clinical stages and shows various oral symptoms, mainly during the secondary stage. The disease can resemble other common oral mucosal conditions, such as infections with nonspecific pharyngitis, tonsillitis and laryngitis, as well as neoplastic and immune-mediated ulcers. This report discusses a heterosexual couple with rare manifestations of primary and secondary syphilis involving oropharyngeal lesions and an extragenital chancre, highlighting the diagnostic challenge and the importance of clinical awareness for early detection and treatment.\n                  <\/jats:p>","DOI":"10.1136\/sextrans-2025-056784","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T18:20:33Z","timestamp":1766600433000},"page":"185-186","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Extragenital chancre mimicking breast cancer and oropharyngeal secondary syphilis in a heterosexual couple: an unusual clinical pairing"],"prefix":"10.1136","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9116-3218","authenticated-orcid":false,"given":"Khulood","family":"Almarzooqi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Sheikh Khalifa Medical City, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Borg","sequence":"additional","affiliation":[{"name":"University of Malta, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naifah","family":"Almeheri","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sheikh Khalifa Medical City, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Muscat","sequence":"additional","affiliation":[{"name":"Medical Imaging Department, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Ceci","sequence":"additional","affiliation":[{"name":"Pathology Department, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Abdilla","sequence":"additional","affiliation":[{"name":"Medical Imaging Department, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-9230","authenticated-orcid":false,"given":"Valeska","family":"Padovese","sequence":"additional","affiliation":[{"name":"Genitourinary Clinic, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"2026041607151266000_102.3.185.1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01283-4"},{"key":"2026041607151266000_102.3.185.2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.idcr.2017.04.015","article-title":"Secondary syphilis-related oral mucous patches","volume":"9","author":"Liu","year":"2017","journal-title":"IDCases"},{"key":"2026041607151266000_102.3.185.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.09.067"},{"key":"2026041607151266000_102.3.185.4","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-024-10129-1","article-title":"Description of clinical cases and available diagnostic tools of oropharyngeal syphilis: a systematic review of the literature","volume":"24","author":"Guarino","year":"2024","journal-title":"BMC Infect Dis"},{"key":"2026041607151266000_102.3.185.5","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.oooo.2025.07.001","article-title":"Acquired oral syphilis: epidemiology, diagnostic pitfalls, and treatment strategies","volume":"140","author":"Barreto","year":"2025","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2025-056784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T14:15:19Z","timestamp":1776348919000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2025-056784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,4,16]]},"published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1136\/sextrans-2025-056784"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2025-056784","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]}}}