{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:48:10Z","timestamp":1787060890256,"version":"build-2736575974"},"reference-count":14,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Support Palliat Care"],"accepted":{"date-parts":[[2025,9,7]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Chemotherapy-induced peripheral neuropathy (CIPN) is a detrimental side effect of chemotherapeutic agents. If left untreated, CIPN can persist for several years following the chemotherapy. CIPN management may enhance the quality of life of the affected patients. This study evaluated the efficacy of memantine, an antagonist of N-methyl-D-aspartate, in CIPN management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This double-blinded randomised clinical trial was performed on 176 individuals with CIPN. Patients were randomised to either the memantine or placebo groups (88 in each). The memantine group received a single daily dose of 5 mg for the initial 3 days. Subsequently, the dosage was increased to 20 mg per day, with 5 mg increments every 3 days. The placebo group received tablets of equal shape and size. All individuals received medications for 8 weeks. The McGill pain questionnaire and tuning fork test were used to evaluate the severity of neuropathic pain in patients, both at baseline and after the intervention ended.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Based on tuning fork test results, significant improvement in neuropathy was observed among patients who received memantine compared with those who received placebo (p&lt;0.001 vs 0.665). McGill pain questionnaire score revealed a significant difference between memantine and placebo groups (p&lt;0.001 for both groups). This difference was also significant after performing intention-to-treat analysis. Moreover, a higher proportion of patients in the memantine group achieved minimal clinically important difference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of memantine mitigated the CIPN intensity. Thus, it appears that memantine is a promising option for the management of patients experiencing CIPN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/spcare-2024-005348","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T07:40:20Z","timestamp":1759822820000},"page":"682-686","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Memantine efficacy in chemotherapy-induced peripheral neuropathy: double-blind placebo-controlled randomised clinical trial"],"prefix":"10.1136","volume":"16","author":[{"given":"Niloofar","family":"Esmaili","sequence":"first","affiliation":[{"name":"Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-2105","authenticated-orcid":false,"given":"Samineh","family":"Beheshtirouy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Sanaat","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnaz","family":"Shaseb","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvin","family":"Sarbakhsh","sequence":"additional","affiliation":[{"name":"Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Ghaffary","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"2026042802201397000_16.3.682.1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061451","article-title":"Mechanisms of Chemotherapy-Induced Peripheral Neuropathy","volume":"20","author":"Zaj\u0105czkowska","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2026042802201397000_16.3.682.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.020"},{"key":"2026042802201397000_16.3.682.3","doi-asserted-by":"publisher","DOI":"10.2174\/1389200219666171207121313"},{"key":"2026042802201397000_16.3.682.4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01399"},{"key":"2026042802201397000_16.3.682.5","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1080\/21655979.2022.2026553","article-title":"Memantine ameliorates oxaliplatin-induced neurotoxicity via mitochondrial protection","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"2026042802201397000_16.3.682.6","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(75)90044-5"},{"key":"2026042802201397000_16.3.682.7","doi-asserted-by":"publisher","DOI":"10.4158\/EP.13.1.5"},{"key":"2026042802201397000_16.3.682.8","doi-asserted-by":"publisher","DOI":"10.1021\/jm060728b"},{"key":"2026042802201397000_16.3.682.9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1200\/JCO.2022.40.4_suppl.083","article-title":"Preventives for oxaliplatin-induced peripheral neuropathy in colorectal cancer patients","volume":"40","author":"Hines","year":"2022","journal-title":"JCO"},{"key":"2026042802201397000_16.3.682.10","doi-asserted-by":"crossref","unstructured":"Mohammadzadeh P , Shaseb E , Sanaat Z , et al . Prophylactic effect of memantine in docetaxel induced neuropathy in patients with breast cancer. In Review [Preprint] 2021. doi:10.21203\/rs.3.rs-692391\/v1","DOI":"10.21203\/rs.3.rs-692391\/v1"},{"key":"2026042802201397000_16.3.682.11","doi-asserted-by":"crossref","unstructured":"Shaseb E , Farashi E , Ghadim HH , et al . Memantine as a Potential Therapy in Subacute Herpetic Neuralgia: A Randomized Clinical Trial. jpc 2022. doi:10.18502\/jpc.v10i4.11579","DOI":"10.18502\/jpc.v10i4.11579"},{"key":"2026042802201397000_16.3.682.12","doi-asserted-by":"crossref","DOI":"10.1177\/14791641231191093","article-title":"Management of diabetic neuropathy with memantine: A randomized clinical trial","volume":"20","author":"Jafarzadeh","year":"2023","journal-title":"Diab Vasc Dis Res"},{"key":"2026042802201397000_16.3.682.13","doi-asserted-by":"crossref","DOI":"10.1186\/1745-6215-15-331","article-title":"Prevention of post-mastectomy neuropathic pain with memantine: study protocol for a randomized controlled trial","volume":"15","author":"Pickering","year":"2014","journal-title":"Trials"},{"key":"2026042802201397000_16.3.682.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0374-x"}],"container-title":["BMJ Supportive &amp; Palliative Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/spcare-2024-005348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:22:41Z","timestamp":1777368161000},"score":1,"resource":{"primary":{"URL":"https:\/\/spcare.bmj.com\/lookup\/doi\/10.1136\/spcare-2024-005348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,4,28]]},"published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1136\/spcare-2024-005348"],"URL":"https:\/\/doi.org\/10.1136\/spcare-2024-005348","relation":{},"ISSN":["2045-435X","2045-4368"],"issn-type":[{"value":"2045-435X","type":"print"},{"value":"2045-4368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]}}}