{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:30:47Z","timestamp":1776439847287,"version":"3.51.2"},"reference-count":5,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Support Palliat Care"],"accepted":{"date-parts":[[2025,7,11]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>This report focuses on the case of a woman in her 80s struggling with pruritus of a likely multifactorial cause within an inpatient unit at a hospice. Subcutaneous chlorphenamine 10mg twice daily, was used when the oral route was unavailable. Pruritus and associated rash resolved within 6 days of treatment being commenced. There was no further rash or pruritus after this. There is little literature about the use of subcutaneous chlorphenamine and this case report highlights its use can be effective for treatment of pruritus in palliative care and broaden therapeutic options. Further research is needed to support its use when administered subcutaneously.<\/jats:p>","DOI":"10.1136\/spcare-2025-005641","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T17:20:18Z","timestamp":1753723218000},"page":"82-84","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Subcutaneous chlorphenamine for pruritus"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7627-7642","authenticated-orcid":false,"given":"Genevieve","family":"Perrins","sequence":"first","affiliation":[{"name":"St Gemma\u2019s Hospice, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"2026041707351383000_16.1.82.1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.15586\/aei.v50iSP2.784","article-title":"Etiological causes in patients with acute urticaria and angioedema","volume":"50","author":"Meliko\u011flu","year":"2022","journal-title":"Allergol Immunopathol"},{"key":"2026041707351383000_16.1.82.2","doi-asserted-by":"publisher","DOI":"10.1177\/106002808401800905"},{"key":"2026041707351383000_16.1.82.3","first-page":"1010","article-title":"Pruritus in palliative care: Getting up to scratch","volume":"57","author":"Seccareccia","year":"2011","journal-title":"Can Fam Physician"},{"key":"2026041707351383000_16.1.82.4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/jamainternmed.2014.7663","article-title":"Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study","volume":"175","author":"Gray","year":"2015","journal-title":"JAMA Intern Med"},{"key":"2026041707351383000_16.1.82.5","unstructured":"Electronic Medicines Compendium . Chlorphenamine 10mg\/ml solution for injection. Surrey (UK): Datapharm. Available: https:\/\/www.medicines.org.uk\/emc\/product\/10595\/smpc [Accessed 15 May 2025]."}],"container-title":["BMJ Supportive &amp; Palliative Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/spcare-2025-005641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:35:39Z","timestamp":1776436539000},"score":1,"resource":{"primary":{"URL":"https:\/\/spcare.bmj.com\/lookup\/doi\/10.1136\/spcare-2025-005641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12,23]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1136\/spcare-2025-005641"],"URL":"https:\/\/doi.org\/10.1136\/spcare-2025-005641","relation":{},"ISSN":["2045-435X","2045-4368"],"issn-type":[{"value":"2045-435X","type":"print"},{"value":"2045-4368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]}}}