{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:16:43Z","timestamp":1787912203698,"version":"build-2784847793"},"reference-count":48,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Support Palliat Care"],"accepted":{"date-parts":[[2025,11,12]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pharmacotherapy has a strategic role in palliative care (PC). Medications are prescribed in this context for various reasons, leading to polypharmacy, associated with several negative outcomes. Despite its clinical relevance, the scientific literature about pharmacological interventions in PC remains scarce and fragmented. This review aimed to explore and map the pharmacological interventions in PC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A bibliometric review was conducted using combined data from Scopus and Web of Science. Inclusion criteria covered original articles and reviews, published between 2014 and 2024, that had terms related to PC present in the title and terms related to the use of medications present in the title, abstract or keywords. RStudio and VOSviewer were used to analyse data, focusing on publication trends, authorship, keywords and thematic evolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2245 publications were included, mainly original articles (80%), although only 10% were clinical trials. Highest annual production was found in 2024, concentrating mainly in high-income countries. The term \u201csymptom management\u201d appears as a central term in keyword analysis; it also appears, along with \u201cdeprescribing\u201d and \u201cpolypharmacy\u201d, in trending topics evolution, growing in 2019. Data indicate that pharmacotherapy is not yet a consolidated theme itself, being addressed mainly in more general references.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fragmentation hinders the advancement of key issues such as the identification and management of potentially inappropriate medications, therapeutic rationalisation at the end of life and the pharmacoeconomic impact of these prescriptions and interventions. The field of palliative pharmacotherapy should be considered as a possibility for future literature development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/spcare-2025-005709","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T19:30:22Z","timestamp":1764876622000},"page":"1081-1091","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacotherapy in palliative medicine\u2014a decade of evidence: bibliometric review"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-6719","authenticated-orcid":false,"given":"J\u00falia","family":"Raso","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of Sao Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Rossi","family":"Varallo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of Sao Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"2026082802200694000_16.5.1081.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2020.04.027"},{"key":"2026082802200694000_16.5.1081.2","article-title":"Drug Therapy Safety in Palliative Care-Pharmaceutical Analysis of Medication Processes in Palliative Care","volume":"11","author":"Krumm","year":"2023","journal-title":"Pharmacy (Basel)"},{"key":"2026082802200694000_16.5.1081.3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s11606-019-04837-7","article-title":"Associations Between Polypharmacy, Symptom Burden, and Quality of Life in Patients with Advanced, Life-Limiting Illness","volume":"34","author":"Schenker","year":"2019","journal-title":"J Gen Intern Med"},{"key":"2026082802200694000_16.5.1081.4","doi-asserted-by":"crossref","first-page":"204","DOI":"10.18773\/austprescr.2014.077","article-title":"Pharmacovigilance in palliative care","volume":"37","author":"Rowett","year":"2014","journal-title":"Aust Prescr"},{"key":"2026082802200694000_16.5.1081.5","first-page":"32","article-title":"Polypharmacy: Evaluating Risks and Deprescribing","volume":"100","author":"Halli-Tierney","year":"2019","journal-title":"Am Fam Physician"},{"key":"2026082802200694000_16.5.1081.6","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2018.1546841"},{"key":"2026082802200694000_16.5.1081.7","doi-asserted-by":"publisher","DOI":"10.1093\/ijpp\/riad025"},{"key":"2026082802200694000_16.5.1081.8","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.jgo.2021.06.003","article-title":"Development of criteria for identifying potentially inappropriate prescribing in older adults with cancer receiving palliative care (PIP-CPC)","volume":"12","author":"Cadogan","year":"2021","journal-title":"J Geriatr Oncol"},{"key":"2026082802200694000_16.5.1081.9","doi-asserted-by":"crossref","unstructured":"Ganti L , Persaud NA , Stead TS . 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