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Our results seem to support the theory of its pathogenesis put forward by Bruetsch","volume-title":"The fact that a specific anti-syphilitic drug such as penicillin is more effective in the early stages of the disease, suggests that its efficacy is associated with inhibition of the syphilitic inflammatory process involving the lower optic tract at the base of the skull","year":"1953","unstructured":"distinct signs of preceding inflammation. Our results seem to support the theory of its pathogenesis put forward by Bruetsch (1953). The fact that a specific anti-syphilitic drug such as penicillin is more effective in the early stages of the disease, suggests that its efficacy is associated with inhibition of the syphilitic inflammatory process involving the lower optic tract at the base of the skull. It is then"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/archopht.1952.00920010458009","volume":"48","author":"Benton, C. D. Jr.; Harris, J. 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