{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T16:40:15Z","timestamp":1766940015657},"reference-count":9,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sexually Transmitted Infections"],"published-print":{"date-parts":[[1976,12,1]]},"DOI":"10.1136\/sti.52.6.366","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T20:57:06Z","timestamp":1226523426000},"page":"366-373","source":"Crossref","is-referenced-by-count":3,"title":["Syphilitic aortic regurgitation. An appraisal of surgical treatment."],"prefix":"10.1136","volume":"52","author":[{"given":"W","family":"Grabau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Emanuel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hegde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"1222","volume":"2","author":"BROOKSBY, I.A.B.; JENKINS, B.S.; COLTART, D.J.; WEBB-PEPLOE, M.M.; DAVIES, M.J.","year":"1974","unstructured":"BROOKSBY, I. A. B., JENKINS, B. S., COLTART, D. J., WEBB-PEPLOE, M. M., and DAVIES, M. J. (1974) Lancet, 2, 1222","journal-title":"Lancet"},{"key":"ref_2","first-page":"346","volume":"29","author":"CAMPBELL, M.; SHACKLE, J.W.","year":"1932","unstructured":"CAMPBELL, M., and SHACKLE, J. W. (1932) Brit. med.J_., 1, HEGGTVEIT, H. A. (1964) Circulation, 29, 346","journal-title":"Circulation"},{"key":"ref_3","first-page":"97","article-title":"Brit. J_. vener","volume":"50","author":"INCE, W.E.; MAHABIR, B.S.","year":"1974","unstructured":"INCE, W. E. and MAHABIR, B. S. (1974) Brit.J_. vener. Dis., 50, 97 IoNEscU, M. I., Ross, D. N., DEAC, R., GRIMSHAw, V. A., TAYLOR, S. H., WHITAKER, W., and WOOLER, G. H. (1970) Thorax, 25, 46 KOULUMIES, R., and HEINIVAARA, 0. (1957) Acta med. scand., 159, 453 LEONMD, J. C., and SMITH, W. G. (1957) Lancet, 1, 234 MICHAUD, P., TERMET, H., CHASSIGNOLLE, J., DALLOZ, C., AGE, C., DELAVE, J., DU GRgs, B., and CHAMPSAUR, G. (1970) Arch. Mal. Coeur, 63, 674 PREWITT, T. A. (1970) J. Amer. med. Ass., 211, 637","journal-title":"Dis"},{"key":"ref_4","article-title":"Appendix Case reports","volume":"14","author":"SAMAAN, H.A.","year":"1973","unstructured":"SAMAAN, H. A. (1973) J. cardiovasc. Surg. (Torino), 14, Appendix Case reports","journal-title":"Surg. (Torino)"},{"key":"ref_5","article-title":"Case 2, a 57-year-old white female presented in January 1972 with a 6-month history of paroxysmal dyspnoea, effort dyspnoea, and angina. Clinically there was severe aortic regurgitation. The VDRL, RPCF, FTA-ABS, treponemal immobilization (TPI) tests were all negative, but a chest radiograph showed cardiac enlargement with a dilated calcified ascending aorta and the electrocardiogram indicated left axis deviation and left ventricular hypertrophy with strain. Aortography showed severe aortic regurgitation with aneurysmal dilatation of the ascending aorta. At operation (24.3.72) the aneurysm of the ascending aorta and the dilated aortic root were confirmed. The coronary ostia were normal. The valve and ascending aorta were replaced using a No. 10 StarrEdwards prosthesis and a 35 mm Dacron graft. The postoperative course was uneventful and the patient has remained well with minimal effort dyspnoea for the last 3 years. Histology of the aorta confirmed the presence of syphilis and the aortic cusps were normal","unstructured":"Case 2, a 57-year-old white female presented in January 1972 with a 6-month history of paroxysmal dyspnoea, effort dyspnoea, and angina. Clinically there was severe aortic regurgitation. The VDRL, RPCF, FTA-ABS, treponemal immobilization (TPI) tests were all negative, but a chest radiograph showed cardiac enlargement with a dilated calcified ascending aorta and the electrocardiogram indicated left axis deviation and left ventricular hypertrophy with strain. Aortography showed severe aortic regurgitation with aneurysmal dilatation of the ascending aorta. At operation (24.3.72) the aneurysm of the ascending aorta and the dilated aortic root were confirmed. The coronary ostia were normal. The valve and ascending aorta were replaced using a No. 10 StarrEdwards prosthesis and a 35 mm Dacron graft. The postoperative course was uneventful and the patient has remained well with minimal effort dyspnoea for the last 3 years. Histology of the aorta confirmed the presence of syphilis and the aortic cusps were normal."},{"key":"ref_6","article-title":"Case 3, a 52-year-old white male, presented in September 1972 with a 2-year history of effort dyspnoea","unstructured":"Case 3, a 52-year-old white male, presented in September 1972 with a 2-year history of effort dyspnoea."},{"key":"ref_7","article-title":"a 55-year-old white male with an 18-month history of effort dyspnoea and a 6-month history of angina, presented in January 1968 with left ventricular failure","author":"10, Case","unstructured":"Case 10, a 55-year-old white male with an 18-month history of effort dyspnoea and a 6-month history of angina, presented in January 1968 with left ventricular failure."},{"key":"ref_8","article-title":"Aortography showed aneurysmal dilatation of the ascending aorta","year":"1974","unstructured":"Aortography showed aneurysmal dilatation of the ascending aorta. Operation (January 1974) showed a dissection of the ascending aorta; a Dacron graft was inserted but the patient died from haemorrhage. Post mortem examination of the aorta showed medionecrosis suggesting Marfan's syndrome. The coronary arteries were normal.","journal-title":"Operation; showed a dissection of the ascending aorta; a Dacron graft was inserted but the patient died from haemorrhage. Post mortem examination of the aorta showed medionecrosis suggesting Marfan's syndrome. The coronary arteries were normal"},{"key":"ref_9","article-title":"Case 14, a 51-year-old white male with a 2-year history of effort dyspnoea, developed left ventricular failure in 1972. He had had primary syphilis when aged 19. Clinically there was severe aortic regurgitation. A chest radiograph showed cardiac enlargement with a moderately dilated ascending aorta and the ECG showed left ventricular hypertrophy with strain. Cardiac catheterization and aortography confirmed severe aortic regurgitation with raised left and right heart pressures. The VDRL test was positive 1: 64 and the RPCF and FTA-ABS tests were also positive. He was given procaine penicillin 600,000 units daily for 21 days before surgery. At operation (28.11.72) there was severe aortic regurgitation with thickening and shortening of the valve cusps. The ascending aorta was aneurysmal and there was slight thickening of the intima at the site of the coronary ostia","unstructured":"Case 14, a 51-year-old white male with a 2-year history of effort dyspnoea, developed left ventricular failure in 1972. He had had primary syphilis when aged 19. Clinically there was severe aortic regurgitation. A chest radiograph showed cardiac enlargement with a moderately dilated ascending aorta and the ECG showed left ventricular hypertrophy with strain. Cardiac catheterization and aortography confirmed severe aortic regurgitation with raised left and right heart pressures. The VDRL test was positive 1: 64 and the RPCF and FTA-ABS tests were also positive. He was given procaine penicillin 600,000 units daily for 21 days before surgery. At operation (28.11.72) there was severe aortic regurgitation with thickening and shortening of the valve cusps. The ascending aorta was aneurysmal and there was slight thickening of the intima at the site of the coronary ostia."}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T23:40:14Z","timestamp":1601077214000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sti.52.6.366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,12,1]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1976,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/sti.52.6.366","relation":{},"ISSN":["1368-4973"],"issn-type":[{"value":"1368-4973","type":"print"}],"subject":[],"published":{"date-parts":[[1976,12,1]]}}}