{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:48:56Z","timestamp":1788594536911,"version":"build-2803163510"},"reference-count":33,"publisher":"BMJ","issue":"2","funder":[{"name":"Suzhou Clinical Research Center of Neurological Disease"},{"name":"Jiangsu key laboratory grant"},{"name":"Priority Academic Program Development of the Jiangsu Higher Education Institutions"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Stroke Vasc Neurol"],"accepted":{"date-parts":[[2019,3,5]]},"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Stroke is a cerebrovascular disease displaying high mortality and morbidity. Despite extensive efforts, only very few therapies are available for stroke patients as yet. Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is thought to be a signalling molecule that is endogenously produced and plays functional roles in the central nervous system. Currently, numerous studies show that H<jats:sub>2<\/jats:sub>S impacts stroke outcomes in animal and cellular models. Here, we review the recent research regarding the effects of endogenously produced H<jats:sub>2<\/jats:sub>S as well as exogenous H<jats:sub>2<\/jats:sub>S donors on stroke pathology, focusing on the potential of H<jats:sub>2<\/jats:sub>S-based therapies in treating ischaemic stroke. We also discuss the several issues that hinder the clinical translation of H<jats:sub>2<\/jats:sub>S-based therapies from the bench. Taken together, we think that H<jats:sub>2<\/jats:sub>S-based therapies are promising strategies for treating cerebral ischaemia if we successfully address these issues.<\/jats:p>","DOI":"10.1136\/svn-2018-000194","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T17:15:49Z","timestamp":1562260549000},"page":"63-66","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["H<sub>\n                     <sub>2<\/sub>\n                  <\/sub>S-based therapies for ischaemic stroke: opportunities and challenges"],"prefix":"10.1136","volume":"4","author":[{"given":"Jia","family":"Jia","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 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