{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:51:46Z","timestamp":1755795106556,"version":"3.44.0"},"reference-count":30,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ministry of Health & Welfare, Republic of Korea","award":["HI21C1705","HI22C0782"],"award-info":[{"award-number":["HI21C1705","HI22C0782"]}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2022R1I1A1A01059209"],"award-info":[{"award-number":["2022R1I1A1A01059209"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Stroke Vasc Neurol"],"accepted":{"date-parts":[[2023,9,10]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>To evaluate the association between retinal artery\/arteriole occlusion (RAO) and unruptured intracranial aneurysm (UIA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Incident UIA patients from a nationwide cohort (n=253\u2009240) were categorised into three groups based on subsequent treatment: observation (n=208\u2009993), microsurgical clipping (n=14\u2009168) and endovascular treatment (EVT) groups (n=30\u2009079). The incidence and the incident time of RAO were analysed. HRs of RAO and associated risk factors were evaluated. Additionally, a hospital cohort comprising 2569 consecutive UIA patients treated at a tertiary hospital was analysed with detailed clinical information of UIAs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the nationwide cohort analysis, the incidence of RAO was significantly higher in EVT group than in observation and clipping groups, especially within 60 days (early RAO (within 60 days): HR=4.00, 95%\u2009CI: 2.44 to 6.56); delayed RAO (after 60 days): HR=1.74, 95%\u2009CI: 1.13 to 2.68). Multivariable analysis showed that the presence of chronic kidney disease (p=0.009) and use of a balloon microcatheter during the procedure (p=0.013) were associated with a higher risk of RAO. In hospital cohort analysis, 11 (0.8%) cases of RAO occurred after EVT, whereas none occurred after microsurgical clipping (p&lt;0.001). Patients with RAO were younger and received balloon microcatheters more frequently than their counterparts. Ten cases of RAO (90.9%) occurred in paraclinoid aneurysms, where EVT was preferred over microsurgical clipping.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Performing EVT for UIA may increase the risk of subsequent RAO. Care should be taken when treating paraclinoid aneurysms with balloon microcatheters.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/svn-2023-002563","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T14:30:46Z","timestamp":1696429846000},"page":"295-305","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Retinal artery\/arteriole occlusion risks after endovascular treatment for unruptured intracranial aneurysm"],"prefix":"10.1136","volume":"9","author":[{"given":"Hae Rang","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jeoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (the Republic of)"},{"name":"Department of Neurosurgery, Uijeongbu St. Mary\u2019s Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunyeup","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical AI, Sungkyunkwan University School of Medicine, Suwon, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Soo","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keun Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher Seungkyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk Ho","family":"Byeon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Korea (the Republic 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