{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:43:21Z","timestamp":1792799001597,"version":"4.5.0"},"reference-count":32,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Project of Xiamen Cell Therapy Research","award":["3502Z20214001"],"award-info":[{"award-number":["3502Z20214001"]}]},{"name":"Medical and Health Key Project of Xiamen","award":["3502Z20204006"],"award-info":[{"award-number":["3502Z20204006"]}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82072777"],"award-info":[{"award-number":["82072777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Project of Natural Science Foundation of Fujian Province","award":["2021J02057"],"award-info":[{"award-number":["2021J02057"]}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2022J011358"],"award-info":[{"award-number":["2022J011358"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2022J011365"],"award-info":[{"award-number":["2022J011365"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Xiamen Municipal Health Commission, Xiamen Municipal Bureau of Science and Technology","award":["3502Z20209005"],"award-info":[{"award-number":["3502Z20209005"]}],"id":[{"id":"https:\/\/ror.org\/006mtxa58","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Stroke Vasc Neurol"],"accepted":{"date-parts":[[2024,10,21]]},"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The incidence of cancer-associated ischaemic stroke (IS) is increasingly prevalent. This study aimed to assess the levels of enlarged perivascular spaces in basal ganglion (BG-EPVS) in cancer-associated patients who had a stroke compared with the control group, and to investigate the diagnostic utility of BG-EPVS in the context of cancer-associated stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A matched case\u2013control study was conducted in Xiamen, China. A total of 184 IS patients (cancer vs control=1:1) were recruited. The severity of BG-EPVS was graded using high-resolution MRI. Patients\u2019 gender, age, clinical risk factors, other imaging changes and laboratory findings information at admission were collected. Logistic regression models were constructed and subgroup analysis by cancer treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Overall, 65.22% of the 184 subjects were male, with a mean (SD) age of 68.83\u00b110.52 years. BG-EPVS had a significant influence on cancer-associated stroke (OR=1.85 (95% CI 1.29, 2.71), p=0.001) after adjusting for gender, age, clinical risk factors, other imaging changes and laboratory findings. The area under the curve of the diagnosis model that combined BG-EPVS and other factors was 0.848 (95% CI 0.787, 0.896), significantly higher than the other three models. Subgroup analysis suggested a heightened association between BG-EPVS and cancer-associated stroke within the cancer treatment group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, this is the first study to assess the diagnosis values of BG-EPVS on cancer-associated stroke and helps us understand the pathogenesis of cancer-associated stroke. Our findings demonstrate the effectiveness of BG-EPVS in diagnosing IS patients who may carry underlying cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/svn-2024-003287","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T23:55:13Z","timestamp":1731369313000},"page":"441-451","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Correlation of enlarged perivascular spaces in basal ganglion and cancer-associated stroke: a case\u2013control study in China"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9142-2871","authenticated-orcid":false,"given":"Jielong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganji","family":"Hong","sequence":"additional","affiliation":[{"name":"Cerebrovascular Interventional Department, Zhangzhou Hospital of Fujian Province, Zhangzhou, Fujian, China"},{"name":"The School of Clinical Medicine, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangcheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"The School of Clinical Medicine, Fujian Medical University, Fuzhou, China"},{"name":"Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China"},{"name":"Xiamen Key Laboratory of Brain Center, Xiamen, China"},{"name":"Xiamen Medical Quality Control Center for Neurology, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiedong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"The School of Clinical Medicine, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiamen Susong Hospital, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuya","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"The School of Clinical Medicine, Fujian Medical University, Fuzhou, China"},{"name":"Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China"},{"name":"Xiamen Key Laboratory of Brain Center, Xiamen, China"},{"name":"Xiamen Medical Quality Control Center for Neurology, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"The School of Clinical Medicine, Fujian Medical University, Fuzhou, China"},{"name":"Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China"},{"name":"Xiamen Key Laboratory of Brain Center, Xiamen, China"},{"name":"Xiamen Medical Quality Control Center for Neurology, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"The School of Clinical Medicine, Fujian Medical University, Fuzhou, China"},{"name":"Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China"},{"name":"Xiamen Key Laboratory of Brain Center, Xiamen, China"},{"name":"Xiamen Medical Quality Control Center for Neurology, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Gynecology of Xiamen Maternal and Child Health Care Hospital, Xiamen, China"},{"name":"The Graduate School of Fujian Medical University, Fuzhou, 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Effect of Chemotherapy on Stroke Risk in Cancer Patients","volume":"120","author":"Kitano","year":"2020","journal-title":"Thromb Haemost"},{"key":"2025082602100712000_10.4.441.29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0249099","article-title":"Increased prevalence of obstructive sleep apnea in women diagnosed with endometrial or breast cancer","volume":"16","author":"Madut","year":"2021","journal-title":"PLoS One"},{"key":"2025082602100712000_10.4.441.30","doi-asserted-by":"crossref","first-page":"13701","DOI":"10.1002\/cam4.5999","article-title":"Distress, anxiety, and depression in persons with hereditary cancer syndromes: Results from a nationwide cross-sectional study in Germany","volume":"12","author":"Kastner","year":"2023","journal-title":"Cancer Med"},{"key":"2025082602100712000_10.4.441.31","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.027684","article-title":"Age-Dependent Association Between Modifiable Risk Factors and Incident Cardiovascular 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Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/svn-2024-003287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T09:10:47Z","timestamp":1756199447000},"score":1,"resource":{"primary":{"URL":"https:\/\/svn.bmj.com\/lookup\/doi\/10.1136\/svn-2024-003287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,26]]},"published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1136\/svn-2024-003287"],"URL":"https:\/\/doi.org\/10.1136\/svn-2024-003287","relation":{},"ISSN":["2059-8688","2059-8696"],"issn-type":[{"value":"2059-8688","type":"print"},{"value":"2059-8696","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]}}}