{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:40:36Z","timestamp":1787017236521,"version":"build-2736575974"},"reference-count":27,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101398"],"award-info":[{"award-number":["82101398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Hospitals Authority\u2019s Ascent Plan","award":["DFL20220702"],"award-info":[{"award-number":["DFL20220702"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Stroke Vasc Neurol"],"accepted":{"date-parts":[[2024,10,3]]},"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The efficacy of percutaneous transluminal angioplasty and stenting (PTAS) relative to medical management in treating symptomatic intracranial arterial stenosis (ICAS) varies based on the qualifying artery. This study aims to evaluate PTAS compared with medical therapy alone in cases of ICAS involving the internal carotid artery (ICA), middle cerebral artery (MCA), vertebral artery (VA) and basilar artery (BA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study involves a thorough pooled analysis of individual patient data from two randomised controlled trials, evaluating the efficacy of PTAS in comparison to medical management for symptomatic ICAS with different qualifying arteries. The primary outcome was stroke or death within 30 days postenrolment, or stroke in the region of the qualifying artery beyond 30 days through 1 year. A methodology based on intention-to-treat was employed, and HR accompanied by 95% CIs were used to convey risk estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The data of 809 individuals were collected from Stenting\u2009vs Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis trial and China Angioplasty and Stenting for Symptomatic Intracranial Severe Stenosis trial. Four hundred were designated for PTAS, while 409 were assigned to medical therapy alone. For the primary outcome, patients with symptomatic BA stenosis had a significantly higher risk of receiving PTAS compared with medical therapy (17.17% vs 7.77%; 9.40; HR, 2.38 (1.03 to 5.52); p=0.04). However, PTAS had no significant difference in patients with symptomatic ICA (26.67% vs 16.67%; HR, 1.68 (0.78 to 3.62); p=0.19), MCA (8.28% vs 9.79%; HR, 0.85 (0.42 to 1.74); p=0.66) and VA stenosis (9.52% vs 10.71%; HR, 0.91 (0.32 to 2.62); p=0.86) compared with medical therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PTAS significantly increases the risk of both short-term and long-term stroke in patients with symptomatic BA stenosis. Without significant technological advancements to mitigate these risks, PTAS offers limited benefits. For symptomatic ICA, MCA and VA stenosis, PTAS provided no significant advantage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/svn-2024-003532","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T01:35:19Z","timestamp":1729820119000},"page":"422-430","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Stenting for symptomatic intracranial arterial stenosis with different qualifying arteries: a preplanned pooled individual patient data analysis"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-905X","authenticated-orcid":false,"given":"Tianhua","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-7901","authenticated-orcid":false,"given":"Eyad","family":"Almallouhi","sequence":"additional","affiliation":[{"name":"Neuro Interventional Surgery, Medical University of South Carolina, Charleston, South Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"},{"name":"Department of Interventional Neuroradiology, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangdong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-227X","authenticated-orcid":false,"given":"Haozhi","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoyuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Xing","sequence":"additional","affiliation":[{"name":"Health Science Center, Xian Jiaotong University, Xi'an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin 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Anatomic Characteristics and Eligibility for Carotid Revascularisation in a Chinese Population with Atherosclerotic Carotid Artery Stenosis. Eur J Vasc Endovasc Surg 2023;S1078\u20135884."},{"key":"2025082602100710000_10.4.422.17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.578229"},{"key":"2025082602100710000_10.4.422.18","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.664680"},{"key":"2025082602100710000_10.4.422.19","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s12975-022-01034-3","article-title":"Cerebral Fractional Flow Reserve for Functional Evaluation of Intracranial Atherosclerotic Stenosis","volume":"14","author":"Wang","year":"2023","journal-title":"Transl Stroke Res"},{"key":"2025082602100710000_10.4.422.20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s12975-022-00996-8","article-title":"Endovascular Therapy for Symptomatic Intracranial Artery Stenosis: a Systematic Review and Network Meta-analysis","volume":"13","author":"Wang","year":"2022","journal-title":"Transl Stroke Res"},{"key":"2025082602100710000_10.4.422.21","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2022-002288"},{"key":"2025082602100710000_10.4.422.22","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318271bcb8"},{"key":"2025082602100710000_10.4.422.23","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3171\/2015.8.JNS15791","article-title":"Submaximal angioplasty for symptomatic intracranial atherosclerosis: a prospective Phase I study","volume":"125","author":"Dumont","year":"2016","journal-title":"JNS"},{"key":"2025082602100710000_10.4.422.24","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015451"},{"key":"2025082602100710000_10.4.422.25","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30149-8"},{"key":"2025082602100710000_10.4.422.26","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-020456"},{"key":"2025082602100710000_10.4.422.27","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.532713"}],"container-title":["Stroke and Vascular Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/svn-2024-003532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T09:10:33Z","timestamp":1756199433000},"score":1,"resource":{"primary":{"URL":"https:\/\/svn.bmj.com\/lookup\/doi\/10.1136\/svn-2024-003532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,26]]},"published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1136\/svn-2024-003532"],"URL":"https:\/\/doi.org\/10.1136\/svn-2024-003532","relation":{},"ISSN":["2059-8688","2059-8696"],"issn-type":[{"value":"2059-8688","type":"print"},{"value":"2059-8696","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]}}}