{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:38:50Z","timestamp":1788183530688,"version":"build-2803163510"},"reference-count":25,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Stroke Vasc Neurol"],"accepted":{"date-parts":[[2025,1,23]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Venous thromboembolic events (VTEs) like deep vein thrombosis or pulmonary embolism are frequent complications in (neuro) critical ill patients. Anticoagulation for VTE after space-occupying brain infarction is a therapeutic dilemma. The aim of this retrospective study was to investigate the frequency of clinically apparent VTE in patients with acute ischaemic stroke (AIS) due to large vessel occlusion (LVO), its treatment, and the rate of complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with first AIS due to LVO were assigned to one of the following groups: space-occupying brain infarction with (1) or without (2) decompressive craniectomy (DC), AIS comprising more than 2\/3 (3) or less than 2\/3 (4) of the middle cerebral artery territory. Clinically obtained parameters included risk factors for VTE, type of thromboprophylaxis, treatment of VTE and treatment-associated complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>15 of 173 (8.7%) patients had a VTE, which was diagnosed 10.9 \u00b1 7.2\u2009days after admission. Patients with a space-occupying brain infarction and DC had significantly more VTE (n=11\/63; 17.5%) than patients with a space-occupying brain infarction without DC (0\/26; p =0.023) or patients without DC (4\/110; 3.6%; p = 0.004). Younger age, DC and cumulative duration of central venous catheter were identified as risk factors for VTE. Only three patients had major bleeding events while being anticoagulated (one asymptomatic cerebral and two extracranial bleedings).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Patients with space-occupying brain infarction and DC hold a high risk for VTE. Despite extensive infarct size and DC, therapeutic anticoagulation required for VTE appeared to be safe regarding intracranial bleeding complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/svn-2024-003808","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T12:45:27Z","timestamp":1739277927000},"page":"569-575","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Frequency and treatment of venous thromboembolic events in patients with space-occupying brain infarction and decompressive craniectomy"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6985-5540","authenticated-orcid":false,"given":"Alhuda","family":"Dabbagh","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja S","family":"M\u00fchlberg","sequence":"additional","affiliation":[{"name":"Department of Angiology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Titus","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institute for Neuroradiology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Michalski","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-2280","authenticated-orcid":false,"given":"Johann Otto","family":"Pelz","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"2025102713051377000_10.5.569.1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1177\/0885066618796486","article-title":"Venous Thromboembolism Prophylaxis: A Narrative Review With a Focus on the High-Risk Critically Ill Patient","volume":"34","author":"Lewis","year":"2019","journal-title":"J Intensive Care Med"},{"key":"2025102713051377000_10.5.569.2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s12028-023-01780-8","article-title":"Factors Associated with Venous Thromboembolism Development in Patients with Traumatic Brain Injury","volume":"40","author":"Cole","year":"2024","journal-title":"Neurocrit Care"},{"key":"2025102713051377000_10.5.569.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816150"},{"key":"2025102713051377000_10.5.569.4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12028-016-0252-z","article-title":"Risk of Venous Thromboembolism in Patients with Large Hemispheric Infarction Undergoing Decompressive Hemicraniectomy","volume":"25","author":"Chalouhi","year":"2016","journal-title":"Neurocrit Care"},{"key":"2025102713051377000_10.5.569.5","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.013581"},{"key":"2025102713051377000_10.5.569.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"2025102713051377000_10.5.569.7","doi-asserted-by":"crossref","unstructured":"Pelz JO , Engelmann S , Engelmann C , et al . No Harmful Effect of Endovascular Treatment before Decompressive Surgery-Implications for Handling Patients with Space-Occupying Brain Infarction. 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