{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:31:33Z","timestamp":1775280693790,"version":"3.50.1"},"reference-count":39,"publisher":"BMJ","issue":"4","funder":[{"DOI":"10.13039\/100000026","name":"National Institute of Drug Abuse","doi-asserted-by":"crossref","award":["R21DA054818"],"award-info":[{"award-number":["R21DA054818"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Tob Control"],"accepted":{"date-parts":[[2022,12,16]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>It is unclear whether emerging synthetic tobacco-free nicotine superiority messages such as \u2018better flavor and better experience\u2019 and \u2018no residual impurities of tobacco-derived nicotine\u2019 may impact consumer perception and product choice between synthetic and tobacco-derived nicotine vaping products.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Through a 2022 online survey of current e-cigarette users, we identified synthetic nicotine never users for randomisation into an embedded between-subjects experiment. The test group (n=186) viewed a tobacco-free nicotine message versus no message control (n=168). Multivariable regressions assessed messaging effects on three comparative measures between tobacco-free and tobacco-derived nicotine: harm perception, purchase intention and willingness to pay.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Participants (n=354; age, mean (SD)=34.6 (11.1) years old) were recruited from geographically diverse regions with 27.7% rural residents. The overall sample comprised 44.1% females, 73.5% non-Hispanic white and 71.8% daily e-cigarette users. Sociodemographics and tobacco use status were not significantly different between two randomised groups. The test group (vs control) reported a higher intention to use tobacco-free than tobacco-derived nicotine vaping products (adjusted OR (AOR)=2.4, 95% CI 1.3 to 4.4, p=0.006) and willingness to pay more for tobacco-free nicotine vaping products (AOR=2.6, 95% CI 1.2 to 5.8, p=0.02). Urban (vs rural) synthetic-na\u00efve vapers had lower harm perception (AOR=2.0, 95% CI 1.1 to 3.6, p=0.02) and higher intention to use tobacco-free than tobacco-derived nicotine vaping products (AOR=2.2, 95% CI 1.1 to 4.5, p=0.04); infrequent vapers were more willing to pay more for tobacco-free nicotine vaping products (AOR=1.1, 95% CI 1.03 to 1.17, p=0.002).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Tobacco-free nicotine marketing message may prompt the transition to and promote a price premium for such products. With the proliferation of products in the market, comprehensive regulation of emerging synthetic vaping products is needed.<\/jats:p>\n<\/jats:sec>","DOI":"10.1136\/tc-2022-057507","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T18:48:50Z","timestamp":1672771730000},"page":"441-448","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Randomised experiment for the effect of \u2018Tobacco-Free Nicotine\u2019 messaging on current e-cigarette users\u2019 perceptions, preferences and intentions"],"prefix":"10.1136","volume":"33","author":[{"given":"Kendra","family":"Ratnapradipa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaeli","family":"Samson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1395-7904","authenticated-orcid":false,"given":"Hongying Daisy","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"2024072401151141000_33.4.441.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1917065"},{"key":"2024072401151141000_33.4.441.2","doi-asserted-by":"crossref","unstructured":"Wackowski OA , Giovenco DP , Singh B . Content analysis of US news stories about e-cigarettes in 2015. Nicotine & Tobacco Research 2017.","DOI":"10.1093\/ntr\/ntx170"},{"key":"2024072401151141000_33.4.441.3","unstructured":"Kong G K-SS . Tobacco Free Nicotine (TFN): A New Public Health Challenge. Blog - Tobacco Control, 2021. https:\/\/blogs.bmj.com\/tc\/2021\/07\/03\/tobacco-free-nicotine-tfn-a-new-public-health-challenge\/"},{"key":"2024072401151141000_33.4.441.4","unstructured":"The Food and Drug Administration . Fda finalizes enforcement policy on unauthorized flavored cartridge-based e-cigarettes that appeal to children, including fruit and MINT, 2020. Available: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-finalizes-enforcement-policy-unauthorized-flavored-cartridge-based-e-cigarettes-appeal-children [Accessed 8 May 2022]."},{"key":"2024072401151141000_33.4.441.5","unstructured":"The Food and Drug Administration . 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