{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:01:38Z","timestamp":1793880098275,"version":"4.7.0"},"reference-count":10,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long-Term Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Thorax"],"accepted":{"date-parts":[[2022,12,15]]},"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p><jats:sup>129<\/jats:sup>Xe MRI red blood cell to alveolar tissue plasma ratio (RBC:TP) abnormalities have been observed in ever-hospitalised and never-hospitalised people with postacute COVID-19 syndrome (PACS). But, it is not known if such abnormalities resolve when symptoms and quality-of-life scores improve. We evaluated 21 participants with PACS, 7\u00b14 months (baseline) and 14\u00b14 months (follow-up) postinfection. Significantly improved diffusing capacity of the lung for carbon monoxide (DL<jats:sub>CO<\/jats:sub>, \u0394=14%<jats:sub>pred<\/jats:sub>;95%CI 7 to 21, p&lt;0.001), postexertional dyspnoea (\u0394=\u22120.7; 95%CI=\u22120.2 to \u20131.2, p=0.019), St George\u2019s Respiratory Questionnaire-score (SGRQ \u0394=\u22126; 95% CI=\u22121 to \u201311, p=0.044) but not RBC:TP (\u0394=0.03; 95% CI=0.01 to 0.05, p=0.051) were observed at 14\u2009months. DL<jats:sub>CO<\/jats:sub>correlated with RBC:TP (r=0.60, 95% CI=0.22 to 0.82, p=0.004) at 7\u2009months. While DL<jats:sub>CO<\/jats:sub>and SGRQ measurements improved, these values did not normalise 14\u2009months post-infection. ClinicalTrials.gov<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04584671\">NCT04584671<\/jats:ext-link>.<\/jats:p>","DOI":"10.1136\/thorax-2022-219378","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T18:22:24Z","timestamp":1672770144000},"page":"418-421","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Longitudinal follow-up of postacute COVID-19 syndrome: DL<sub>CO<\/sub>, quality-of-life and MRI pulmonary gas-exchange abnormalities"],"prefix":"10.1136","volume":"78","clinical-trial-number":[{"clinical-trial-number":"nct04584671","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Alexander M","family":"Matheson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marrissa J","family":"McIntosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harkiran K","family":"Kooner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdelrazek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderdeep","family":"Dhaliwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-7967","authenticated-orcid":false,"given":"J Michael","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-2528","authenticated-orcid":false,"given":"Alexei","family":"Ouriadov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Svenningsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5619-4145","authenticated-orcid":false,"given":"Grace","family":"Parraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"2024051320332141000_78.4.418.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26513-3"},{"key":"2024051320332141000_78.4.418.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01283-z"},{"key":"2024051320332141000_78.4.418.3","doi-asserted-by":"crossref","unstructured":"Yoo SM , Liu TC , Motwani Y , et al . Factors associated with post-acute sequelae of SARS-CoV-2 (PASC) after diagnosis of symptomatic COVID-19 in the inpatient and outpatient setting in a diverse cohort. J Gen Intern Med 2022.doi:10.1007\/s11606-022-07523-3","DOI":"10.1007\/s11606-022-07523-3"},{"key":"2024051320332141000_78.4.418.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2020.07.019"},{"key":"2024051320332141000_78.4.418.5","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2021-217031"},{"key":"2024051320332141000_78.4.418.6","article-title":"Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized 129 Xe MRI","volume":"7","author":"Li","year":"2021","journal-title":"Sci Adv"},{"key":"2024051320332141000_78.4.418.7","doi-asserted-by":"crossref","unstructured":"Grist JT , Collier GJ , Walters H , et al . Lung abnormalities depicted with hyperpolarized xenon MRI in patients with long COVID. Radiology 2022:220069.doi:10.1148\/radiol.220069","DOI":"10.1148\/radiol.220069"},{"key":"2024051320332141000_78.4.418.8","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.220492"},{"key":"2024051320332141000_78.4.418.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00063702"},{"key":"2024051320332141000_78.4.418.10","doi-asserted-by":"crossref","unstructured":"Villalba JA , Hilburn CF , Garlin MA , et al . Vasculopathy and increased vascular congestion in fatal COVID-19 and ARDS. Am J Respir Crit Care Med 2022.doi:10.1164\/rccm.202109-2150OC","DOI":"10.1164\/rccm.202109-2150OC"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thorax-2022-219378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T03:49:18Z","timestamp":1715658558000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thorax-2022-219378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,3]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,3,15]]},"published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1136\/thorax-2022-219378"],"URL":"https:\/\/doi.org\/10.1136\/thorax-2022-219378","relation":{},"ISSN":["0040-6376","1468-3296"],"issn-type":[{"value":"0040-6376","type":"print"},{"value":"1468-3296","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,3]]}}}