{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T14:25:43Z","timestamp":1794407143765,"version":"4.9.0"},"reference-count":12,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017647","name":"ResMed","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020974","name":"Philips-Respironics","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020974","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Thorax"],"accepted":{"date-parts":[[2022,12,23]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Home non-invasive mechanical ventilation (HMV) with home oxygen therapy (HOT) in patients with persistent hypercapnia following an acute exacerbation of chronic obstructive pulmonary disease delays hospital readmission. The economic impact of this treatment is unknown. We evaluated the cost-effectiveness of HMV in the UK healthcare system using data from a previously published efficacy trial. Quality-adjusted life-years (QALYs) were computed from EQ-5D-5L. Accounting for all direct patient costs HOT-HMV was \u00a3512 (95%CI \u00a336 to \u00a3990) more expensive per patient per year than HOT-alone. This small increase in cost was accompanied by increased quality of life leading to an incremental cost-effectiveness ratio of \u00a310\u2009259 per QALY. HOT-HMV was cost-effective in this clinical population. Trial registration number: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT00990132\">NCT00990132<\/jats:ext-link>.<\/jats:p>","DOI":"10.1136\/thorax-2022-219653","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T13:21:02Z","timestamp":1677158462000},"page":"523-525","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Cost-effectiveness of home non-invasive ventilation in patients with persistent hypercapnia after an acute exacerbation of COPD in the UK"],"prefix":"10.1136","volume":"78","clinical-trial-number":[{"clinical-trial-number":"nct00990132","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1500-611X","authenticated-orcid":false,"given":"Patrick Brian","family":"Murphy","sequence":"first","affiliation":[{"name":"Lane Fox Respiratory Service, Guy's and St Thomas' NHS Foundation Trust, London, UK"},{"name":"Centre for Human and Applied Physiological Sciences, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Brueggenjuergen","sequence":"additional","affiliation":[{"name":"Orthop\u00e4dische Klinik der Medizinischen Hochschule Hannover (MHH) im DIAKOVERE Annastift, Hannover Medical School Affilliated Hospital, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reinhold","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine, Epidemiology and Health Economics, Charit\u00e9 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and HumboldtUniversit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Gu","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research, Boston Healthcare Associates Inc, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fusfeld","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research, Boston Healthcare Associates Inc, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Criner","sequence":"additional","affiliation":[{"name":"Respiratory Medicine, Temple University, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Goss","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research, Boston Healthcare Associates Inc, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Hart","sequence":"additional","affiliation":[{"name":"Lane Fox Respiratory Service, Guy's and St Thomas' NHS Foundation Trust, London, UK"},{"name":"Centre for Human and Applied Physiological Sciences, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"2025073109050647000_78.5.523.1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.152264"},{"key":"2025073109050647000_78.5.523.2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.10.867"},{"key":"2025073109050647000_78.5.523.3","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1001\/jama.2017.4451","article-title":"Effect of home noninvasive ventilation with oxygen therapy vs oxygen therapy alone on hospital readmission or death after an acute COPD exacerbation: a randomized clinical trial","volume":"317","author":"Murphy","year":"2017","journal-title":"JAMA"},{"key":"2025073109050647000_78.5.523.4","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2015.OA4780"},{"key":"2025073109050647000_78.5.523.5","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-213303"},{"key":"2025073109050647000_78.5.523.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-007082"},{"key":"2025073109050647000_78.5.523.7","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-213622"},{"key":"2025073109050647000_78.5.523.8","doi-asserted-by":"publisher","DOI":"10.3310\/hta19880"},{"key":"2025073109050647000_78.5.523.9","article-title":"Cost-Effectiveness of domiciliary non-invasive ventilation in patients with chronic obstructive pulmonary disease","volume":"77","author":"Hall","year":"2021","journal-title":"Thorax"},{"key":"2025073109050647000_78.5.523.10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b181"},{"key":"2025073109050647000_78.5.523.11","doi-asserted-by":"crossref","DOI":"10.1136\/thorax-2021-218497","article-title":"Cost-Effectiveness of outpatient versus inpatient non-invasive ventilation setup in obesity hypoventilation syndrome: the OPIP trial","volume":"78","author":"Murphy","year":"2023","journal-title":"Thorax"},{"key":"2025073109050647000_78.5.523.12","unstructured":"National Institute for Health and Clinical Excellence . Continuous positive airway pressure for the treatment of obstructive sleep apnoea\/hypopnoea syndrome. technology appraisal guidance. 2008."}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thorax-2022-219653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T16:05:28Z","timestamp":1753977928000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thorax-2022-219653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,23]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,4,13]]},"published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1136\/thorax-2022-219653"],"URL":"https:\/\/doi.org\/10.1136\/thorax-2022-219653","relation":{},"ISSN":["0040-6376","1468-3296"],"issn-type":[{"value":"0040-6376","type":"print"},{"value":"1468-3296","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,23]]}}}