{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:56:03Z","timestamp":1792518963428,"version":"4.5.0"},"reference-count":8,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000292","name":"Cystic Fibrosis Trust","doi-asserted-by":"publisher","award":["In kind support"],"award-info":[{"award-number":["In kind support"]}],"id":[{"id":"10.13039\/501100000292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013589","name":"Research England","doi-asserted-by":"crossref","award":["No grant reference number, value \u00a310,090 from Res"],"award-info":[{"award-number":["No grant reference number, value \u00a310,090 from Res"]}],"id":[{"id":"10.13039\/501100013589","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Thorax"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>In 2018 we published the James Lind Alliance (JLA) top 10 priorities for clinical research in cystic fibrosis (CF), chosen jointly by the patient and clinical communities. These priorities have led to new research funding. To establish whether priorities have changed with novel modulator therapies, we undertook an online international update through a series of surveys and a workshop. Patients and clinicians (n=1417) chose the refreshed top 10 from 971 new research questions (suggested by patients and clinicians) and 15 questions from 2018. We are working with the international community to promote research based on these refreshed top 10 priorities.<\/jats:p>","DOI":"10.1136\/thorax-2023-220100","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T12:30:12Z","timestamp":1686141012000},"page":"840-843","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["A refresh of the top 10 research priorities in cystic fibrosis"],"prefix":"10.1136","volume":"78","clinical-trial-number":[{"clinical-trial-number":"isrctn14081521","registry":"10.18810\/isrctn"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1105-3645","authenticated-orcid":false,"given":"Nicola Jane","family":"Rowbotham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherie","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe C","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Cupid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna J","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5494-5438","authenticated-orcid":false,"given":"Alan Robert","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"2024051409143927000_78.8.840.1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210473"},{"key":"2024051409143927000_78.8.840.2","unstructured":"James Lind Alliance . You said, we did: how the cystic fibrosis priorities have been addressed since they were agreed in 2017. National Institute for Health Research; 2021. Available: https:\/\/www.jla.nihr.ac.uk\/news\/you-said-we-did-how-the-cystic-fibrosis-priorities-have-been-addressed-since-they-were-agreed-in-2017\/29365"},{"key":"2024051409143927000_78.8.840.3","unstructured":"James Lind Alliance . The JLA lab. National Institute for health research; 2023. Available: https:\/\/www.jla.nihr.ac.uk\/jla-lab.htm"},{"key":"2024051409143927000_78.8.840.4","unstructured":"James Lind Alliance . Cystic fibrosis research priorities refresh protocol. National Institute for Health Research; 2021. Available: https:\/\/www.jla.nihr.ac.uk\/documents\/cystic-fibrosis-research-priorities-refresh-protocol\/29556"},{"key":"2024051409143927000_78.8.840.5","unstructured":"James Lind Alliance . JLA guidebook version 10. National Institute for Health Research; 2021. Available: https:\/\/www.jla.nihr.ac.uk\/jla-guidebook\/"},{"key":"2024051409143927000_78.8.840.6","unstructured":"James Lind Alliance . Cystic fibrosis refresh priorities final sheet of data. National Institute for Health Research; 2023. 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