{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:03:12Z","timestamp":1792735392139,"version":"4.5.0"},"reference-count":45,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M022552\/1"],"award-info":[{"award-number":["MR\/M022552\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Thorax"],"accepted":{"date-parts":[[2024,2,1]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Rationale<\/jats:title><jats:p>Increased outdoor air pollution worsens lung function in children. However, these associations are less well studied in preterm-born individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We assessed associations between ambient air pollutants and spirometry measures in preterm-born children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Respiratory Health Outcomes in Neonates study recruited preterm-born children aged 7\u201312 years who were born at \u226434 week's gestation. We associated four ambient air pollutants (particulate matter with aerodynamic diameter \u22642.5\u2009\u00b5m (PM<jats:sub>2.5<\/jats:sub>), PM<jats:sub>10<\/jats:sub>, nitrogen dioxide (NO<jats:sub>2<\/jats:sub>) and sulfur dioxide) at time of birth and spirometry assessment and averaged exposure between these two time points with spirometry measures, using linear regression analyses. Gestational age was banded into 23\u201328, 29\u201331 and 32\u201334 week's. Regression models estimated spirometry values against pollutant levels at birth and at the time of spirometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and main results<\/jats:title><jats:p>From 565 preterm-born children, 542 (96%) had satisfactory data. After adjustments for early and current life factors, significant detrimental associations were noted between PM<jats:sub>10<\/jats:sub>at birth and per cent predicted forced vital capacity (%FVC) for the 23\u201328 and 29\u201331 week's gestation groups and between current PM<jats:sub>2.5<\/jats:sub>and NO<jats:sub>2<\/jats:sub>exposure and %FVC for the 23\u201328 week's gestation group. No associations with spirometry were noted for the averaged pollution exposure between birth and spirometry. Predictive models showed 5.9% and 7.4% differences in %FVC between the highest and lowest current pollution exposures for PM<jats:sub>2.5<\/jats:sub>and NO<jats:sub>2,<\/jats:sub>respectively, in the 23\u201328 week group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Birth and current exposures to road-traffic-associated pollutants detrimentally affected %FVC in preterm-born school-aged children, who already have compromised lung function.<\/jats:p><\/jats:sec>","DOI":"10.1136\/thorax-2023-220233","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T18:25:44Z","timestamp":1708021544000},"page":"553-563","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of ambient air pollution on lung function in preterm-born school-aged children"],"prefix":"10.1136","volume":"79","author":[{"given":"William 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