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Considering that the extracellular vesicle (EV) was an emerging intercellular communication medium, recent studies have highlighted the crucial role of environmental pollutants derived EVs (EPE-EVs) in respiratory disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed and Web of Science were searched from January 2018 to December 2023 for publications with key words of environmental pollutants, respiratory disorders and EVs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Environmental pollutants could disrupt airway intercellular communication by indirectly stimulating airway barrier cells to secrete endogenous EVs, or directly transmitting exogenous EVs, mainly by biological pollutants. Mechanistically, EPE-EVs transferred specific contents to modulate biological functions of recipient cells, to induce respiratory inflammation and impair tissue and immune function, which consequently contributed to the development of respiratory diseases, such as asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary hypertension, lung cancer and infectious lung diseases. Clinically, EVs could emerged as promising biomarkers and biological agents for respiratory diseases attributed by their specificity, convenience, sensibility and stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Further studies of EPE-EVs are helpful to understand the aetiology and pathology of respiratory diseases, and facilitate the precision respiratory medicine in risk screening, early diagnosis, clinical management and biotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/thorax-2023-221302","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T13:20:44Z","timestamp":1713360044000},"page":"680-691","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Environmental pollutants exposure-derived extracellular vesicles: crucial players in respiratory disorders"],"prefix":"10.1136","volume":"79","author":[{"given":"Haoran","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2733-6490","authenticated-orcid":false,"given":"Mulong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-0242","authenticated-orcid":false,"given":"David C","family":"Christiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"2025012402150626000_79.7.680.1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S2213-2600(20)30105-3","article-title":"Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"8","author":"Soriano","year":"2020","journal-title":"Lancet Respir Med"},{"key":"2025012402150626000_79.7.680.2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S2213-2600(21)00555-5","article-title":"Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene-environment interactions across the lifespan","volume":"10","author":"Agust\u00ed","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2025012402150626000_79.7.680.3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.envint.2018.11.017","article-title":"Genome-wide interaction study of gene-by-occupational exposures on respiratory symptoms","volume":"122","author":"Zeng","year":"2019","journal-title":"Environ Int"},{"key":"2025012402150626000_79.7.680.4","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/S0140-6736(16)31597-5","article-title":"Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action","volume":"388","author":"Guan","year":"2016","journal-title":"The Lancet"},{"key":"2025012402150626000_79.7.680.5","doi-asserted-by":"crossref","unstructured":"Chormare R , Kumar MA . 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