{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:51:01Z","timestamp":1776423061836,"version":"3.51.2"},"reference-count":19,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the French National Health Insurance (Occupational Risk Prevention Department","award":["'no award\/grant number\u2019"],"award-info":[{"award-number":["'no award\/grant number\u2019"]}]},{"name":"the French Agency for Food, Environmental and Occupational Health & Safety","award":["ANSES Grant 07-CRD-51 and EST 2006\/1\/43 and EST 20"],"award-info":[{"award-number":["ANSES Grant 07-CRD-51 and EST 2006\/1\/43 and EST 20"]}]},{"name":"the French Ministry of Labour and Social Relations","award":["'no award\/grant number\u2019"],"award-info":[{"award-number":["'no award\/grant number\u2019"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Thorax"],"accepted":{"date-parts":[[2025,10,16]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asbestos, mineral wool (MW), refractory ceramic fibres (RCF) and silica are among the most common exposures to mineral particles in the workplace.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the effect of coexposure to asbestos and MW, crystalline silica or RCFs and the risk of lung cancer and mesothelioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Asbestos-Related Diseases Cohort is a surveillance programme in retired workers exposed to asbestos during their working life. Complete job histories were collected and occupational exposure to asbestos was assessed by an expert, while occupational exposure to MW, RCFs and silica was assessed using French job-exposure matrices. Cox proportional hazards models were used to estimate HR and 95% CI for lung cancer mortality and lung cancer incidence and for mesothelioma mortality or mesothelioma incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this population of workers exposed to asbestos, in the mortality study, exposures to MW, crystalline silica and RCFs were not found to be associated with lung cancer after adjustment for smoking and asbestos, nor with mesothelioma after adjustment for asbestos. In the incidence study, there was an association between exposure to crystalline silica (ever exposed) and mesothelioma (HR\n                      <jats:sub>a<\/jats:sub>\n                      =1.75, 95% CI 1.17 to 2.62).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Crystalline silica is not known to induce mesothelioma but coexposure to asbestos could increase the effect of asbestos on the mesothelial cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/thorax-2024-222020","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:40:23Z","timestamp":1763664023000},"page":"430-438","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Coexposure to asbestos, mineral wool, crystalline silica and refractory ceramic fibres and risk of lung cancer and mesothelioma"],"prefix":"10.1136","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-5405","authenticated-orcid":false,"given":"Fleur","family":"Delva","sequence":"first","affiliation":[{"name":"CHU de Bordeaux, Bordeaux, France"},{"name":"Bordeaux Population Health Research Center, Equipe EPICENE, INSERM U1219, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Gramond","sequence":"additional","affiliation":[{"name":"Bordeaux Population Health Research Center, Equipe EPICENE, INSERM U1219, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Thaon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, INSPIIRE, Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aude","family":"Lacourt","sequence":"additional","affiliation":[{"name":"Bordeaux Population Health Research Center, Equipe EPICENE, INSERM U1219, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Brochard","sequence":"additional","affiliation":[{"name":"Bordeaux Population Health Research Center, Equipe EPICENE, INSERM U1219, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Benoist","sequence":"additional","affiliation":[{"name":"Institut Interuniversitaire de M\u00e9decine du Travail de Paris-Ile de France, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Gislard","sequence":"additional","affiliation":[{"name":"Occupational Diseases Department, Rouen University Hospital, Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-2340","authenticated-orcid":false,"given":"Francois","family":"Laurent","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6417-4980","authenticated-orcid":false,"given":"Christophe","family":"Paris","sequence":"additional","affiliation":[{"name":"Occupational Diseases, University Hospital Centre Rennes, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Andujar","sequence":"additional","affiliation":[{"name":"Institut Interuniversitaire de M\u00e9decine du Travail de Paris-Ile de France, Cr\u00e9teil, France"},{"name":"Service de Pneumologie et Pathologie Professionnelle, Centre Hospitalier Intercommunal de Cr\u00e9teil, Cr\u00e9teil, France"},{"name":"INSERM U955, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Clin","sequence":"additional","affiliation":[{"name":"Service de Sant\u00e9 au Travail et Pathologie Professionnelle, CHU Caen, Caen, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Caen Normandie, Caen, France"},{"name":"ANTICIPE, INSERM U1086, Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Pairon","sequence":"additional","affiliation":[{"name":"Institut Interuniversitaire de M\u00e9decine du Travail de Paris-Ile de France, Cr\u00e9teil, France"},{"name":"Service de Pneumologie et Pathologie Professionnelle, Centre Hospitalier Intercommunal de Cr\u00e9teil, Cr\u00e9teil, France"},{"name":"INSERM U955, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"2026041604050859000_81.5.430.1","unstructured":"IARC Monograph on the Evaluation of Carcinogenic Risks to Humans . 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