{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:39:02Z","timestamp":1790728742135,"version":"4.1.0"},"reference-count":39,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/501100004365","name":"Sydney Medical School","doi-asserted-by":"publisher","award":["no award\/grant number"],"award-info":[{"award-number":["no award\/grant number"]}],"id":[{"id":"10.13039\/501100004365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022986","name":"Ross Trust","doi-asserted-by":"publisher","award":["no award\/grant number"],"award-info":[{"award-number":["no award\/grant number"]}],"id":[{"id":"10.13039\/501100022986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002284","name":"Asthma Australia","doi-asserted-by":"publisher","award":["no award\/grant number"],"award-info":[{"award-number":["no award\/grant number"]}],"id":[{"id":"10.13039\/501100002284","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Thorax"],"accepted":{"date-parts":[[2025,5,26]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oscillometry may provide the feasible and sensitive tool for objective remote monitoring of paediatric asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational study of school-aged healthy, well-controlled and poorly-controlled asthma performing daily home-based oscillometry for 3\u20134 months, alongside objective measures of asthma control (Asthma Control Questionnaire weekly and Asthma Control Test monthly), medication use and exacerbations. Day-to-day variability calculated as coefficient of variation (CV) for resistance at 5\u2009Hz (R5), reactance at 5 Hz (X5) and area under reactance curve (AX). Our objective was to examine feasibility, whether day-to-day variability was increased in asthma and correlations with asthma control and exacerbation burden. Clinical exacerbation patterns were examined using principal component analysis and k-means clustering of oscillometry, symptoms, breathing parameters and adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Feasibility was 74.9\u00b116.0% in health (n=13, 93.7\u00b116.2\u2009days) and 80.6\u00b112.9% in asthma (n=42, 101.6\u00b124.9\u2009days; 17 well-controlled and 27 poorly-controlled asthma). Increased day-to-day variability in all oscillometry indices occurred in asthma versus health (all p\u22640.002), with CV R5 the best discriminator (area under receiver operating characteristics curve 0.88, p&lt;0.001). CV R5 increased during exacerbation and correlated with all asthma control measures and exacerbation burden. Correlations remained when examining non-exacerbation oscillometry data. Two exacerbation patterns were found based on oscillometry data in the pre-exacerbation period, characterised by severity of impairment of R5, X5, AX and CV R5 (n=12, more severe). Findings were similar using post-exacerbation period oscillometry data (n=8, more severe). Symptoms did not differ across exacerbation patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Home-based oscillometry monitoring was highly feasible over extended periods in school-aged asthmatics. Day-to-day oscillometry variability was increased in asthma compared with health, reflected asthma control and exacerbation burden and identified differing exacerbation patterns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/thorax-2024-222744","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:20:37Z","timestamp":1750771237000},"page":"42-50","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Day-to-day variability indices improve utility of oscillometry in paediatric asthma"],"prefix":"10.1136","volume":"81","author":[{"given":"Minh Trang","family":"Hoang","sequence":"first","affiliation":[{"name":"University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Wong","sequence":"additional","affiliation":[{"name":"Concord Hospital, Concord, New South Wales, 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