{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:02:31Z","timestamp":1790100151450,"version":"4.0.1"},"reference-count":37,"publisher":"BMJ","funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/23496-8"],"award-info":[{"award-number":["2019\/23496-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Thorax"],"accepted":{"date-parts":[[2026,8,27]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It remains unclear whether obstructive sleep apnoea (OSA) and its treatment influence cardiovascular and sleep health in bed partners.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this placebo-controlled trial, patients with moderate\/severe OSA who had bed partners were randomly assigned to receive continuous positive airway pressure (CPAP) or placebo (nasal strips). At baseline and after 3 months, the bed partners underwent clinical evaluation, endothelial function (flow-mediated dilation, FMD), 24-hour ambulatory blood pressure (BP) monitoring, sleep questionnaires and 1-week wrist actigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 63 couples were recruited (34 patients randomised to CPAP and 29 to nasal strips). At baseline, bed partners showed impaired FMD and a higher frequency of long sleep latency, fragmented sleep, short sleep duration and poor sleep quality. Mean adherence to CPAP and nasal strips in OSA patients was 5.7\u00b11.7 hours and 93.1%\u00b112.6%, respectively. Compared with placebo, bed partners of patients assigned to CPAP did not change FMD (\u0394: \u22120.94% (6.03%; 2.24%) vs \u0394: \u22123.27% (\u22126.50%; 1.76%), p=0.67). However, significant differences were observed for 24-hour systolic BP (CPAP: \u22120.85\u00b15.22 mm Hg; placebo: +3.14\u00b18.00 mm Hg; p=0.03), daytime systolic BP (CPAP: \u22121.2\u00b15.5 mm Hg; placebo: +3.8\u00b18.8 mm Hg; p=0.01) and night-time heart rate (CPAP: \u22123\u00b16 bpm; placebo: +2\u00b17 bpm; p=0.01). They improved sleep quality (p=0.02), decreased daytime sleepiness (p=0.01), time awake after sleep onset (CPAP: \u22124.71\u00b120.32 min; placebo: +7.36\u00b117.51 min; p=0.002) and number of awakenings (CPAP: \u22120.97\u00b19.42; placebo: +2.83\u00b19.14; p=0.02). In a stratified analysis by CPAP adherence, endothelial function in bed partners was preserved with optimal use (\u22656 hours\/night), but worsened with lower adherence (p=0.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OSA treatment did not improve endothelial function in bed partners but prevented BP increases, alongside improvements in sleep quality, daytime sleepiness and sleep fragmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT03011294\">NCT03011294<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/thorax-2026-225271","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:20:25Z","timestamp":1790097625000},"page":"thorax-2026-225271","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of obstructive sleep apnoea treatment on cardiovascular and sleep health in bed partners: the sleep partners clinical trial"],"prefix":"10.1136","clinical-trial-number":[{"clinical-trial-number":"nct03011294","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct03011294","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Sara Q C","family":"Giamp\u00e1","sequence":"first","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Laborat\u00f3rio do Sono, LIM 63, Divis\u00e3o de Pneumologia, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia F","family":"Furlan","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Laborat\u00f3rio do Sono, LIM 63, Divis\u00e3o de Pneumologia, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago A","family":"Macedo","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda CSG","family":"Cruz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio do Sono, LIM 63, Divis\u00e3o de Pneumologia, Instituto do Cora\u00e7\u00e3o (InCor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara L","family":"Cabrini","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Disciplina de Nefrologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"de Barros","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Disciplina de Nefrologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, 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