{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:48:35Z","timestamp":1790700515268,"version":"4.1.0"},"reference-count":39,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1136\/thoraxjnl-2012-203106","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T21:39:46Z","timestamp":1361914786000},"page":"571-579","source":"Crossref","is-referenced-by-count":101,"title":["Contribution of host, bacterial factors and antibiotic treatment to mortality in adult patients with bacteraemic pneumococcal pneumonia"],"prefix":"10.1136","volume":"68","author":[{"given":"Pontus","family":"Naucler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Darenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Morfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"\u00d6rtqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Henriques Normark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"key-10.1136\/thoraxjnl-2012-203106-1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1055\/s-2005-925523","article-title":"Streptococcus pneumoniae: epidemiology, risk factors, and clinical features","volume":"26","author":"Ortqvist","year":"2005","journal-title":"Semin Respir Crit Care Med"},{"key":"key-10.1136\/thoraxjnl-2012-203106-2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1086\/518538","article-title":"Association of serotypes of Streptococcus pneumoniae with disease severity and outcome in adults: an international study","volume":"45","author":"Alanee","year":"2007","journal-title":"Clin Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-3","doi-asserted-by":"crossref","first-page":"e1000081","DOI":"10.1371\/journal.pmed.1000081","article-title":"Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study","volume":"6","author":"Harboe","year":"2009","journal-title":"PLoS Med"},{"key":"key-10.1136\/thoraxjnl-2012-203106-4","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1086\/315761","article-title":"Molecular epidemiology of Streptococcus pneumoniae causing invasive disease in 5 countries","volume":"182","author":"Henriques","year":"2000","journal-title":"J Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-5","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1086\/600045","article-title":"Invasive pneumococcal disease among adults: associations among serotypes, disease characteristics, and outcome","volume":"49","author":"Jansen","year":"2009","journal-title":"Clin Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1086\/315760","article-title":"Prospective study of prognostic factors in community-acquired bacteremic pneumococcal disease in 5 countries","volume":"182","author":"Kalin","year":"2000","journal-title":"J Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/jama.1996.03530270034028","article-title":"Bacteremia with Streptococcus pneumoniae. Implications for therapy and prevention. Franklin County Pneumonia Study Group","volume":"275","author":"Plouffe","year":"1996","journal-title":"JAMA"},{"key":"key-10.1136\/thoraxjnl-2012-203106-8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1086\/499242","article-title":"Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen","volume":"42","author":"Sjostrom","year":"2006","journal-title":"Clin Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-9","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1086\/655828","article-title":"Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis","volume":"51","author":"Weinberger","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-10","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1183\/09031936.06.00126004","article-title":"Impact of initial antibiotic choice on mortality from pneumococcal pneumonia","volume":"27","author":"Aspa","year":"2006","journal-title":"Eur Respir J"},{"issue":"1A","key":"key-10.1136\/thoraxjnl-2012-203106-11","doi-asserted-by":"crossref","first-page":"34S","DOI":"10.1016\/S0002-9343(99)00098-4","article-title":"Bacteremic pneumococcal pneumonia in one American city: a 20-year longitudinal study, 1978\u20131997","volume":"107","author":"Mufson","year":"1999","journal-title":"Am J Med"},{"key":"key-10.1136\/thoraxjnl-2012-203106-12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1086\/367541","article-title":"Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia","volume":"36","author":"Martinez","year":"2003","journal-title":"Clin Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-13","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1164\/rccm.200311-1578OC","article-title":"Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia","volume":"170","author":"Baddour","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"key-10.1136\/thoraxjnl-2012-203106-14","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s10096-006-0183-2","article-title":"Addition of a macrolide to a ss-lactam in bacteremic pneumococcal pneumonia","volume":"25","author":"Dwyer","year":"2006","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-15","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1086\/423820","article-title":"Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children","volume":"190","author":"Brueggemann","year":"2004","journal-title":"J Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-16","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1086\/381686","article-title":"Effect of clonal and serotype-specific properties on the invasive capacity of Streptococcus pneumoniae","volume":"189","author":"Sandgren","year":"2004","journal-title":"J Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-17","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nrmicro2011","article-title":"The rise and fall of bacterial clones: Streptococcus pneumoniae","volume":"6","author":"Henriques-Normark","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"key-10.1136\/thoraxjnl-2012-203106-18","volume-title":"Modern epidemiology","author":"Rothman","year":"1998","edition":"2"},{"key":"key-10.1136\/thoraxjnl-2012-203106-19","unstructured":"http:\/\/www.scb.se\/default____2154.aspx (accessed 1 July 2010)."},{"key":"key-10.1136\/thoraxjnl-2012-203106-20","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1080\/00365540500264050","article-title":"Swedish guidelines for the management of community-acquired pneumonia in immunocompetent adults","volume":"37","author":"Hedlund","year":"2005","journal-title":"Scand J Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-21","first-page":"2582","article-title":"[Management of adult patients with community-acquired pneumonia. Evidence-based guidelines from the Swedish Infectious Diseases Association]","volume":"105","author":"Stralin","year":"2008","journal-title":"Lakartidningen"},{"key":"key-10.1136\/thoraxjnl-2012-203106-22","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint Tables for Interpretation of MICs and Zone Diameters. Version 2.0, 1st Jan 2012. http:\/\/www.eucast.org\/clinical_breakpoints\/ (accessed 1 Jun 2012)."},{"key":"key-10.1136\/thoraxjnl-2012-203106-23","doi-asserted-by":"crossref","first-page":"b2393","DOI":"10.1136\/bmj.b2393","article-title":"Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls","volume":"338","author":"Sterne","year":"2009","journal-title":"BMJ"},{"key":"key-10.1136\/thoraxjnl-2012-203106-24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/sim.4067","article-title":"Multiple imputation using chained equations: issues and guidance for practice","volume":"30","author":"White","year":"2011","journal-title":"Stat Med"},{"key":"key-10.1136\/thoraxjnl-2012-203106-25","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/ije\/31.5.1030","article-title":"An overview of relations among causal modelling methods","volume":"31","author":"Greenland","year":"2002","journal-title":"Int J Epidemiol"},{"key":"key-10.1136\/thoraxjnl-2012-203106-26","first-page":"394","article-title":"Licensure of 13-valent pneumococcal conjugate vaccine for adults aged 50 years and older","volume":"61","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.1136\/thoraxjnl-2012-203106-27","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-28","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1001\/archinte.168.7.749","article-title":"Invasive pneumococcal disease among White Mountain Apache adults, 1991\u20132005","volume":"168","author":"Bliss","year":"2008","journal-title":"Arch Intern Med"},{"key":"key-10.1136\/thoraxjnl-2012-203106-29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1471-2334-8-96","article-title":"Invasive pneumococcal infections among persons with and without underlying medical conditions: implications for prevention strategies","volume":"8","author":"Klemets","year":"2008","journal-title":"BMC Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2174\/138945009787122879","article-title":"Pathophysiology of sepsis in the elderly: clinical impact and therapeutic considerations","volume":"10","author":"De Gaudio","year":"2009","journal-title":"Curr Drug Targets"},{"key":"key-10.1136\/thoraxjnl-2012-203106-31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1473-3099(02)00437-1","article-title":"Ageing and infection","volume":"2","author":"Gavazzi","year":"2002","journal-title":"Lancet Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-32","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.exger.2012.04.004","article-title":"Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia","volume":"47","author":"Boyd","year":"2012","journal-title":"Exp Gerontol"},{"key":"key-10.1136\/thoraxjnl-2012-203106-33","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1469-0691.2003.00520.x","article-title":"Clinical and microbiological epidemiology of Streptococcus pneumoniae bacteremia in eight French counties","volume":"9","author":"Maugein","year":"2003","journal-title":"Clin Microbiol Infect"},{"key":"key-10.1136\/thoraxjnl-2012-203106-34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1086\/520209","article-title":"Penicillin resistance and other predictors of mortality in pneumococcal bacteremia in a population with high human immunodeficiency virus seroprevalence","volume":"29","author":"Turett","year":"1999","journal-title":"Clin Infect Dis"},{"key":"key-10.1136\/thoraxjnl-2012-203106-35","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1586\/erv.11.99","article-title":"Pneumococcal polysaccharide vaccination for adults: new perspectives for Europe","volume":"10","author":"Fedson","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"key-10.1136\/thoraxjnl-2012-203106-36","first-page":"1102","article-title":"Updated recommendations for prevention of invasive pneumococcal disease among adults using the 23-valent pneumococcal polysaccharide vaccine (PPSV23)","volume":"59","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.1136\/thoraxjnl-2012-203106-37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/01.CCM.0000114817.58194.BF","article-title":"Prospective observational study of bacteremic pneumococcal pneumonia: effect of discordant therapy on mortality","volume":"32","author":"Lujan","year":"2004","journal-title":"Crit Care Med"},{"key":"key-10.1136\/thoraxjnl-2012-203106-38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijantimicag.2010.04.001","article-title":"Comparison of clinical features, antimicrobial susceptibility, serotype distribution and outcomes of patients with hospital- and community-associated invasive pneumococcal disease","volume":"36","author":"Lin","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"key-10.1136\/thoraxjnl-2012-203106-39","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<681::AID-SIM71>3.0.CO;2-R","article-title":"Multiple imputation of missing blood pressure covariates in survival analysis","volume":"18","author":"van Buuren","year":"1999","journal-title":"Stat Med"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thoraxjnl-2012-203106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T18:16:06Z","timestamp":1601057766000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thoraxjnl-2012-203106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,26]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,5,8]]},"published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1136\/thoraxjnl-2012-203106"],"URL":"https:\/\/doi.org\/10.1136\/thoraxjnl-2012-203106","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717982217.793479538","asserted-by":"object"}]},"ISSN":["0040-6376","1468-3296"],"issn-type":[{"value":"0040-6376","type":"print"},{"value":"1468-3296","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,26]]}}}