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A parametric repeated time-to-event model quantitatively described the risk and factors associated with acquiring\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      and\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      from birth until age 5 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cross-sectional analysis found that the number of\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      eradication courses increased the odds of detecting\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      at age 5 years (OR 1.61, 95% CI 1.23 to 2.12). The median (IQR) age for the first\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      positive culture was 2.38 (1.32\u20133.79) years and 3.69 (1.68\u20134.74) years for the first\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      positive culture. The risk of\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      and\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      events changes with time after the first year of study entry. It also decreases for\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      after completing\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      eradication (HR 0.15, 95% CI 0.00 to 0.79), but increases for\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      events (HR 2.75, 95% CI 1.45 to 5.41). The risk of acquiring both types of events increases after having had a previous event.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In young children with CF, completing\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      eradication therapy and previous\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      events are associated with increased risk of acquiring\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/thoraxjnl-2018-211548","type":"journal-article","created":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T17:19:08Z","timestamp":1560619148000},"page":"740-748","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["<i>Pseudomonas aeruginosa<\/i>\n                    eradication therapy and risk of acquiring\n                    <i>Aspergillus<\/i>\n                    in young children with cystic fibrosis"],"prefix":"10.1136","volume":"74","author":[{"given":"Sabariah Noor","family":"Harun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas H G","family":"Holford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Grimwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E","family":"Wainwright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Hennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,6,15]]},"reference":[{"key":"2024092104401301000_74.8.740.1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)00576-6"},{"key":"2024092104401301000_74.8.740.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2012.10.004"},{"key":"2024092104401301000_74.8.740.3","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112897"},{"key":"2024092104401301000_74.8.740.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00166412"},{"key":"2024092104401301000_74.8.740.5","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201309-303OC"},{"key":"2024092104401301000_74.8.740.6","doi-asserted-by":"publisher","DOI":"10.1086\/314727"},{"key":"2024092104401301000_74.8.740.7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00248102"},{"key":"2024092104401301000_74.8.740.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2011.01.002"},{"key":"2024092104401301000_74.8.740.9","unstructured":"The Canadian Cystic Fibrosis Registry 2012 Annual Report . 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