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This gene encodes the heavy chain subunit of axonemal dynein, which is involved with ATP in the motile cilia function.<\/jats:p><jats:p>Our goal was to identify genetic variants at other genes interacting with ETS in BHR by investigating all genes belonging to the \u2018<jats:italic>ATP-binding<\/jats:italic>\u2019 and \u2018<jats:italic>ATPase activity<\/jats:italic>\u2019 pathways which include <jats:italic>DNAH9,<\/jats:italic> are targets of cigarette smoke and play a crucial role in the airway inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Family-based interaction tests between ETS-exposed and unexposed BHR siblings were conducted in 388 EGEA families. Twenty single-nucleotide polymorphisms (SNP) showing interaction signals (p<jats:italic>\u2264<\/jats:italic>5.10<jats:sup>\u22123<\/jats:sup>) were tested in the 253 Saguenay-Lac-Saint-Jean (SLSJ) families.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One of these SNPs was significantly replicated for interaction with ETS in SLSJ families (p=0.003). Another SNP reached the significance threshold after correction for multiple testing in the combined analysis of the two samples (p=10<jats:sup>\u22125<\/jats:sup>). Results were confirmed using both a robust log-linear test and a gene-based interaction test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The SNPs showing interaction with ETS belong to the <jats:italic>ATP8A1<\/jats:italic> and <jats:italic>ABCA1<\/jats:italic> genes, which play a role in the maintenance of asymmetry and homeostasis of lung membrane lipids.<\/jats:p><\/jats:sec>","DOI":"10.1136\/thoraxjnl-2018-211797","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T16:34:13Z","timestamp":1538584453000},"page":"254-260","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families"],"prefix":"10.1136","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8460-7667","authenticated-orcid":false,"given":"Marie-H\u00e9l\u00e8ne","family":"Dizier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Margaritte-Jeannin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucile","family":"Pain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chlo\u00e9","family":"Sarnowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Brossard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamida","family":"Mohamdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nolwenn","family":"Lavielle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claude C","family":"Babron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyne","family":"Just","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Lathrop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Laprise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Bouzigon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Demenais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4938-9339","authenticated-orcid":false,"given":"Rachel","family":"Nadif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"2020050723472332000_74.3.254.1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00135108"},{"key":"2020050723472332000_74.3.254.2","first-page":"253","article-title":"Genetic polymorphisms and associated susceptibility to asthma","volume":"6","author":"March","year":"2013","journal-title":"Int J Gen Med"},{"key":"2020050723472332000_74.3.254.3","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32835c1674"},{"key":"2020050723472332000_74.3.254.4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1289\/EHP376","article-title":"Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies","volume":"125","author":"Rava","year":"2017","journal-title":"Environ Health Perspect"},{"key":"2020050723472332000_74.3.254.5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.3.8810605"},{"key":"2020050723472332000_74.3.254.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200810-1621OC"},{"key":"2020050723472332000_74.3.254.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01939.x"},{"key":"2020050723472332000_74.3.254.8","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12019"},{"key":"2020050723472332000_74.3.254.9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.2001101"},{"key":"2020050723472332000_74.3.254.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806604"},{"key":"2020050723472332000_74.3.254.11","doi-asserted-by":"publisher","DOI":"10.1038\/nature06014"},{"key":"2020050723472332000_74.3.254.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.049"},{"key":"2020050723472332000_74.3.254.13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201830"},{"key":"2020050723472332000_74.3.254.14","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00849-2015"},{"key":"2020050723472332000_74.3.254.15","doi-asserted-by":"crossref","unstructured":"Sugier PE , Brossard M , Sarnowski C , et al . 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