{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:54:31Z","timestamp":1760982871282},"reference-count":13,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1973,9,1]]},"DOI":"10.1136\/thx.28.5.551","type":"journal-article","created":{"date-parts":[[2008,12,13]],"date-time":"2008-12-13T02:58:29Z","timestamp":1229137109000},"page":"551-558","source":"Crossref","is-referenced-by-count":33,"title":["Effects of chlorphentermine on the rat lung"],"prefix":"10.1136","volume":"28","author":[{"given":"D.","family":"Heath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Hasleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","article-title":"Kay and","author":"Kay; Heath","year":"1969","unstructured":"Kay and Heath (1969) Kay and Heath (1969) Kay et al. (1971) Burns (1972) Kay et al. (1971)","journal-title":"Heath (1969) Kay et al. (1971) Burns (1972) Kay et al"},{"key":"ref_2","article-title":"This paper","year":"1973","unstructured":"This paper Heath et al. (1973)","journal-title":"Heath et al"},{"key":"ref_3","article-title":"Although we have shown that the short-term administration of chlorphentermine does not give rise to HPVD, it is clear that this drug produces pronounced changes in the lung parenchyma. There is a striking hyperplasia of the granular pneumocytes lining the alveolar spaces and at the same time numerous cells with foamy cytoplasm appear in the alveoli. These cells were first reported by Franken, Lullman, and Siegfriedt (1970), who found them in 70% of all pulmonary alveoli of rats given intraperitoneal injections of chlorphentermine at a dosage of 50 mg of the drug per kg body weight. Their tinctorial reactions were similar to those reported here. We found it impossible to determine the nature of these intraalveolar foam cells on light microscopy and hence we subjected the lung to electron microscopy. These further ultrastructural studies are described in the following paper. They revealed the pathology of chlorphentermine lung to be complex but gave a clearer understanding of its pathogenesis","unstructured":"Although we have shown that the short-term administration of chlorphentermine does not give rise to HPVD, it is clear that this drug produces pronounced changes in the lung parenchyma. There is a striking hyperplasia of the granular pneumocytes lining the alveolar spaces and at the same time numerous cells with foamy cytoplasm appear in the alveoli. These cells were first reported by Franken, Lullman, and Siegfriedt (1970), who found them in 70% of all pulmonary alveoli of rats given intraperitoneal injections of chlorphentermine at a dosage of 50 mg of the drug per kg body weight. Their tinctorial reactions were similar to those reported here. We found it impossible to determine the nature of these intraalveolar foam cells on light microscopy and hence we subjected the lung to electron microscopy. These further ultrastructural studies are described in the following paper. They revealed the pathology of chlorphentermine lung to be complex but gave a clearer understanding of its pathogenesis."},{"key":"ref_4","article-title":"From the initial study by light microscopy described here we concluded that the short-term administration of chlorphentermine does not lead to unequivocal HPVD but that its long-term effects on the pulmonary vasculature should be investigated. We also concluded that this drug produces striking effects on the lung parenchyma and we consider the nature of these in the following paper","year":"1973","unstructured":"From the initial study by light microscopy described here we concluded that the short-term administration of chlorphentermine does not lead to unequivocal HPVD but that its long-term effects on the pulmonary vasculature should be investigated. We also concluded that this drug produces striking effects on the lung parenchyma and we consider the nature of these in the following paper (Smith et al., 1973)."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/path.1711060306","article-title":"The heart and pulmonary arteries in rats fed on Senecio jacobaea","volume":"106","author":"Burns, J.","year":"1972","unstructured":"Burns, J. (1972). The heart and pulmonary arteries in rats fed on Senecio jacobaea. Journal of Pathology, 106, 187.","journal-title":"Journal of Pathology"},{"key":"ref_6","first-page":"417","article-title":"The occurrence of huge cells in pulmonary alveoli of rats treated by an anorexic drug","volume":"20","author":"Franken, G.; Luilman, H.; Siegfriedt, A.","year":"1970","unstructured":"Franken, G., Luilman, H., and Siegfriedt, A. (1970). The occurrence of huge cells in pulmonary alveoli of rats treated by an anorexic drug. Arzneimittel-Forschung, 20, 417.","journal-title":"Arzneimittel-Forschung"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/hrt.14.3.413","article-title":"Ventricular weight in cardiac hypertrophy","volume":"14","author":"Fulton, R.M.; Hutchinson, E.C.; Jones, A.M.","year":"1952","unstructured":"Fulton, R. M., Hutchinson, E. C., and Jones, A. M. (1952). Ventricular weight in cardiac hypertrophy. British Heart Journal, 14, 413.","journal-title":"British Heart Journal"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/thx.28.1.24","article-title":"Effects on the right ventricle, pulmonary vasculature, and carotid bodies of the rat of exposure to, and recovery from, simulated high altitude","volume":"28","author":"Heath, D.; Edwards, C.; Winson, M.; Smith, P.","year":"1973","unstructured":"Heath, D., Edwards, C., Winson, M., and Smith, P. (1973). Effects on the right ventricle, pulmonary vasculature, and carotid bodies of the rat of exposure to, and recovery from, simulated high altitude. Thorax, 28, 24.","journal-title":"Thorax"},{"key":"ref_9","first-page":"66","article-title":"Crotalaria spectabilis. The PulmonarY Hypertension Plant","author":"Kay, J.M.; Heath, D.","year":"1969","unstructured":"Kay, J. M., and Heath, D. (1969). Crotalaria spectabilis. The PulmonarY Hypertension Plant, p. 66."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/thx.26.3.249","article-title":"Fulvine and the pulmonary circulation","volume":"26","author":"Smith, P.; Bras, G.; Summerell, J.","year":"1971","unstructured":"Smith, P., Bras, G., and Summerell, J. (1971). Fulvine and the pulmonary circulation. Thorax, 26, 249.","journal-title":"Thorax"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/thx.26.3.262","article-title":"Aminorex and the pulmonary circulation","volume":"26","author":"Smith, P.; Heath, D.","year":"1971","unstructured":"Smith, P., and Heath, D. (1971). Aminorex and the pulmonary circulation. Thorax, 26, 262.","journal-title":"Thorax"},{"key":"ref_12","first-page":"110","volume-title":"Chlorphentermine hydrochloride. In the Extra Pharmacopoeia","author":"Martindale, W.","year":"1972","unstructured":"Martindale, W. (1972). Chlorphentermine hydrochloride. In the Extra Pharmacopoeia, 26th ed., edited by N. W. Blacow, p. 110. The Pharmaceutical Press, London.","edition":"26th ed"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/thx.28.5.559","article-title":"Electron microscopy of chlorphentermine lung","volume":"28","author":"Smith, P.; Heath, D.; Hasleton, P.S.","year":"1973","unstructured":"Smith, P., Heath, D., and Hasleton, P. S. (1973). Electron microscopy of chlorphentermine lung. Thorax, 28, 559.","journal-title":"Thorax"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.28.5.551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:26:52Z","timestamp":1601112412000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.28.5.551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,9,1]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1973,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/thx.28.5.551","relation":{},"ISSN":["0040-6376"],"issn-type":[{"value":"0040-6376","type":"print"}],"subject":[],"published":{"date-parts":[[1973,9,1]]}}}