{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:41:37Z","timestamp":1776883297348,"version":"3.51.2"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1975,2,1]]},"DOI":"10.1136\/thx.30.1.80","type":"journal-article","created":{"date-parts":[[2008,12,13]],"date-time":"2008-12-13T02:58:29Z","timestamp":1229137109000},"page":"80-85","source":"Crossref","is-referenced-by-count":15,"title":["A trial of oral delta-1-(trans)-tetrahydrocannabinol in reversible airways obstruction."],"prefix":"10.1136","volume":"30","author":[{"given":"B H","family":"Davies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Radcliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Seaton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0002-8703(74)90033-7","article-title":"Some cardiovascular effects of cannabis","volume":"87","author":"Beaconsfield, P.","year":"1974","unstructured":"Beaconsfield, P. (1974). Some cardiovascular effects of cannabis. American Heart Journal, 87, 143.","journal-title":"American Heart Journal"},{"key":"ref_2","article-title":"Prostaglandins and cannabis. II. Inhibition of biosynthesis by the naturally occurring cannabinoids","author":"Burstein, S.; Levin, E.; Varanelli, C.","year":"1973","unstructured":"Burstein, S., Levin, E., and Varanelli, C. (1973). Prostaglandins and cannabis. II. Inhibition of biosynthesis by the naturally occurring cannabinoids."},{"key":"ref_3","article-title":"The mode of action of Al-THC in producing","author":"Davies, B.H.; Graham, J.D.P.; Griffiths, R.D.; bronchodilatation","year":"1974","unstructured":"The mode of action of Al-THC in producing Davies, B. H., Graham, J. D. P., Griffiths, R. D., and bronchodilatation, if not related to its psychotropic action, is unclear. Beaconsfield (1974) has suggested that stimulation of the \/-adrenoreceptors of the sympathetic nervous system may occur, but the in Weatherstone, R. M. (1974). A pilot study of orally administered Al-trans-tetrahydrocannabinol in the management of patients undergoing radiotherapy for carcinoma of the bronchus. British Journal of Clinical Pharmacology. (In press).","journal-title":"Beaconsfield; if not related to its psychotropic action, is unclear"},{"key":"ref_4","article-title":"vitro studies reported above on the response","volume-title":"Cardiovascular guinea-pig tracheal smooth muscle do not support and respiratory effects of cannabis in cat and rat","author":"of Graham, J.D.P.; Li, D.M.F.","year":"1973","unstructured":"vitro studies reported above on the response of Graham, J. D. P. and Li, D. M. F. (1973). Cardiovascular guinea-pig tracheal smooth muscle do not support and respiratory effects of cannabis in cat and rat."},{"key":"ref_5","first-page":"1","article-title":"British Journal","volume":"49","unstructured":"British Journal ofPharmacology, 49, 1.","journal-title":"ofPharmacology"},{"key":"ref_6","article-title":"Studies previously reported from our laboratories","volume-title":"On the Measurement of Mood","author":"Green, R.F.","year":"1965","unstructured":"Studies previously reported from our laboratories Green, R. F. (1965). On the Measurement of Mood."},{"key":"ref_7","article-title":"also indicate that there is no inhibitory effect on the adrenergic receptors, the pressor effect of noradrenaline being potentiated by injected A1-THC","volume-title":"A more recent pharmacological effect of A1-THC, noted in isolated seminal vesicles, is an inhibition of the synthesis of prostaglandins E1 and E2","author":"(Burstein, Levin,","year":"1973","unstructured":"also indicate that there is no inhibitory effect on the adrenergic receptors, the pressor effect of noradrenaline being potentiated by injected A1-THC (Graham and Li, 1973). A more recent pharmacological effect of A1-THC, noted in isolated seminal vesicles, is an inhibition of the synthesis of prostaglandins E1 and E2 (Burstein, Levin, and Varanelli, 1973). The effect of prostaglandins on bronchial muscle is now well established (Horton, 1969), prostaglandins E1 and E2 being bronchodilators and F2a being a potent bronchoconstrictor. No studies have been reported on the effect of Al-THC"},{"key":"ref_8","series-title":"Archives of Otolaryngology","first-page":"248","article-title":"Respiratory manifestations of hashish smoking","volume":"95","year":"1972","unstructured":"Technical Report No. 10, Research Project N.R. 171-342, Department of Psychology, University of Rochester, Mass., U.S.A. Henderson, R. L., Tennant, F. S., and Guerry, R. (1972). Respiratory manifestations of hashish smoking. Archives of Otolaryngology, 95, 248."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1152\/physrev.1969.49.1.122","article-title":"Hypotheses on physiological roles of prostaglandins","volume":"49","author":"Horton, E.W.","year":"1969","unstructured":"Horton, E. W. (1969). Hypotheses on physiological roles of prostaglandins. Physiological Review, 49, 122.","journal-title":"Physiological Review"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0031-6997(25)06900-5","article-title":"Marijuana-induced 'high': influence of expectation, setting and previous drug experience","volume":"23","author":"Jones, R.T.","year":"1971","unstructured":"Jones, R. T. (1971). Marijuana-induced 'high': influence of expectation, setting and previous drug experience. Pharmacological Reviews, 23, 359.","journal-title":"Pharmacological Reviews"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/235397a0","article-title":"Stimulus characteristics of marijuana components","volume":"235","author":"Kubena, R.K.; Barry, H.","year":"1972","unstructured":"Kubena, R. K. and Barry, H. (1972). Stimulus characteristics of marijuana components. Nature, 235, 397.","journal-title":"Nature"},{"key":"ref_12","first-page":"637","article-title":"Comparison of two oral selective fi2-adrenergic effect through modulation of the response of the stimulant drugs in bronchial asthma. British Medical bronchial smooth muscle to prostaglandins","volume":"1","author":"Legge, J.S.; Gaddie, J.; Palmer, K.N.V.","year":"1971","unstructured":"Legge, J. S., Gaddie, J., and Palmer, K. N. V. (1971). Comparison of two oral selective fi2-adrenergic effect through modulation of the response of the stimulant drugs in bronchial asthma. British Medical bronchial smooth muscle to prostaglandins. Journal, 1, 637.","journal-title":"Journal"},{"key":"ref_13","first-page":"620","article-title":"The long-term effects of cannabis smoking are as","volume":"69","author":"McNair, D.M.","year":"1964","unstructured":"The long-term effects of cannabis smoking are as McNair, D. M. and Lorr, M. J. (1964). An analysis of yet unknown. A recent report (Henderson, Tennant, and Guerry, 1972) suggests that symptoms of mood in neurotics. Journal of Abnormal and Social Psychology, 69, 620.","journal-title":"Journal of Abnormal and Social Psychology; An analysis of yet unknown. A recent report"},{"key":"ref_14","article-title":"respiratory mucosae with atypical cells. The subp","volume-title":"Cannabinoids and cannabis activity. In Cannabis and its Derivatives","author":"Levy, S.; Edery, H.; Grunfeld, Y.","year":"1972","unstructured":"Levy, S., Edery, H., and Grunfeld, Y. (1972). Cannabinoids and cannabis activity. In Cannabis and its Derivatives, edited by W. D. M. Paton and J. Crown, respiratory mucosae with atypical cells. The subp."},{"key":"ref_15","first-page":"50","article-title":"jective benefit of cannabis in asthma has been","volume-title":"that its potency relates to that of coffee Cannabis and its Derivatives; previously. Salter (1860), in a treatise on asthma, The general pharmacology of cannabinoids. In noted its cultivation as an anti-asthmatic in India. The effects were described as 'the same effects as coffee, only in a more marked degree:-it exhilarates, imparts great activity and intensity to the intellectual faculties and exalts the functions of animal life'. It may well be","author":"Paton, W.D.M.; noted Paton, W.D.M.; Pertwee, R.G.; Temple, D.","year":"1972","unstructured":"Oxford University Press, London. jective benefit of cannabis in asthma has been noted Paton, W. D. M., Pertwee, R. G., and Temple, D. (1972). previously. Salter (1860), in a treatise on asthma, The general pharmacology of cannabinoids. In noted its cultivation as an anti-asthmatic in India. The effects were described as 'the same effects as coffee, only in a more marked degree:-it exhilarates, imparts great activity and intensity to the intellectual faculties and exalts the functions of animal life'. It may well be that its potency relates to that of coffee Cannabis and its Derivatives, edited by W. D. M. Paton and J. Crown, p. 50. Oxford University Press, London."},{"key":"ref_16","first-page":"203","article-title":"On Asthma: Its Pathology and Treatment: Treatment of Asthmatic Paroxysm (continued) Treatment by Sedatives","author":"Salter, H.H.","year":"1860","unstructured":"Salter, H. H. (1860). On Asthma: Its Pathology and Treatment: Treatment of Asthmatic Paroxysm (continued) Treatment by Sedatives, p. 203. John Churchill, London."},{"key":"ref_17","article-title":"rather than that of the more recently","author":"Tashkin, D.P.; Shapiro, B.J.; Frank, I.M.","year":"1973","unstructured":"rather than that of the more recently developed - Tashkin, D. P., Shapiro, B. J., and Frank, I. M. (1973)."},{"key":"ref_18","first-page":"420","article-title":"Acute effects of smoked marijuana and oral Pg-tetrahydrocannabinol on specific airway conductance in asthmatic subjects","volume":"109","author":"and","year":"1974","unstructured":", and (1974). Acute effects of smoked marijuana and oral Pg-tetrahydrocannabinol on specific airway conductance in asthmatic subjects. American Review of Respiratory Diseases, 109, 420.","journal-title":"American Review of Respiratory Diseases"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1056\/NEJM197305102881902","article-title":"Single-dose effect of marihuana smoke","volume":"288","author":"Vachon, L.; FitzGerald, M.X.; Solliday, N.H.; Gould, I.A.; Gaensler, E.A.","year":"1973","unstructured":"Vachon, L., FitzGerald, M. X., Solliday, N. H., Gould, I. A., and Gaensler, E. A. (1973). Single-dose effect of marihuana smoke. New England Journal of Medicine, 288, 985. Requests for reprints to: Dr. A. Seaton, Asthma Research Unit, Sully Hospital, Penarth, Glamorgan CF6 2YA.","journal-title":"New England Journal of Medicine; Requests for reprints to: Dr. A"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.30.1.80","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T05:02:38Z","timestamp":1738818158000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.30.1.80"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,2,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/thx.30.1.80","relation":{},"ISSN":["0040-6376"],"issn-type":[{"value":"0040-6376","type":"print"}],"subject":[],"published":{"date-parts":[[1975,2,1]]}}}