{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:14Z","timestamp":1761058874893},"reference-count":19,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1981,10,1]]},"DOI":"10.1136\/thx.36.10.774","type":"journal-article","created":{"date-parts":[[2008,12,13]],"date-time":"2008-12-13T03:15:45Z","timestamp":1229138145000},"page":"774-780","source":"Crossref","is-referenced-by-count":39,"title":["Penetration of piperacillin into bronchial mucosa and sputum."],"prefix":"10.1136","volume":"36","author":[{"given":"G E","family":"Marlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K R","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Burgoyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G R","family":"Funnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M D","family":"Guinness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"358","article-title":"Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents","volume":"13","author":"Fu, K.P.; Neu, H.C.","year":"1978","unstructured":"Fu KP, Neu HC. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother 1978;13:358-67.","journal-title":"Chemother"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/AAC.13.3.484","article-title":"Susceptibility of cephalothin-resistant gram-negative bacilli to piperacillin, cefuroxime, and other selected antibiotics","volume":"13","author":"George, W.L.; Lewis, R.P.; Meyer, R.D.","year":"1978","unstructured":"George WL, Lewis RP, Meyer RD. Susceptibility of cephalothin-resistant gram-negative bacilli to piperacillin, cefuroxime, and other selected antibiotics. Antimicrob Agents Chemother 1978;13:484-9.","journal-title":"Antimicrob Agents Chemother"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1128\/AAC.14.5.643","article-title":"Susceptibility of the anaerobic bacteria, group D Streptococci, Enterobacteriaceae, and Pseudomonas to semisynthetic penicillins: carbenicillin, piperacillin and ticarcillin","volume":"14","author":"Monif, G.R.G.; Clark, P.R.; Shuster, J.J.; Baer, H.","year":"1978","unstructured":"Monif GRG, Clark PR, Shuster JJ, Baer H. Susceptibility of the anaerobic bacteria, group D Streptococci, Enterobacteriaceae, and Pseudomonas to semisynthetic penicillins: carbenicillin, piperacillin and ticarcillin. Antimicrob Agents Chemother 1978;14:643-9.","journal-title":"Antimicrob Agents Chemother"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1128\/AAC.13.3.349","article-title":"In vitro activity of piperacillin, a new semisynthetic penicillin with an unusually broad spectrum of activity","volume":"13","author":"Verbist, L.","year":"1978","unstructured":"Verbist L. In vitro activity of piperacillin, a new semisynthetic penicillin with an unusually broad spectrum of activity. Antimicrob Agents Chemother 1978;13:349-57.","journal-title":"Antimicrob Agents Chemother"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1128\/AAC.14.1.78","article-title":"Piperacillin: in vitro evaluation","volume":"14","author":"Bodey, G.P.; Le Blanc, B.","year":"1978","unstructured":"Bodey GP, Le Blanc B. Piperacillin: in vitro evaluation. Antimicrob Agents Chemother 1978;14:78-87.","journal-title":"Antimicrob Agents Chemother"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1128\/AAC.15.1.137","article-title":"Susceptibility of gram-negative aerobic bacilli resistant to carbenicillin in a general hospital to piperacillin and ticarcillin","volume":"15","author":"McGowan, J.E.; Terry, P.M.","year":"1979","unstructured":"McGowan JE, Terry PM. Susceptibility of gram-negative aerobic bacilli resistant to carbenicillin in a general hospital to piperacillin and ticarcillin. Antimicrob Agents Chemother 1979;15:137-9.","journal-title":"Antimicrob Agents Chemother"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1128\/AAC.15.4.540","article-title":"Comparative in vitro activity of azlocillin, ampicillin, mezlocillin, piperacillin, and ticarcillin, alone and in combination with an aminoglycoside","volume":"15","author":"White, G.W.; Malow, J.B.; Zimelis, V.M.; Pahlavanzadeh, H.; Panwalker, A.P.; Jackson, G.G.","year":"1979","unstructured":"White GW, Malow JB, Zimelis VM, Pahlavanzadeh H, Panwalker AP, Jackson GG. Comparative in vitro activity of azlocillin, ampicillin, mezlocillin, piperacillin, and ticarcillin, alone and in combination with an aminoglycoside. Antimicrob Agents Chemother 1979;15:540-3.","journal-title":"Antimicrob Agents Chemother"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1128\/AAC.14.6.829","article-title":"Piperacillin: human pharmacokinetics after intravenous and intramuscular administration","volume":"14","author":"Tjandramaga, T.B.; Mullie, A.; Verbesselt, R.; de Schepper, P.J.; Verbist, L.","year":"1978","unstructured":"Tjandramaga TB, Mullie A, Verbesselt R, de Schepper PJ, Verbist L. Piperacillin: human pharmacokinetics after intravenous and intramuscular administration. Antimicrob Agents Chemother 1978;14:829-37.","journal-title":"Antimicrob Agents Chemother"},{"key":"ref_9","article-title":"Chemotherapy of chronic bronchitis and allied disorders. Second edition","author":"May, JR","year":"1972","unstructured":"May JR. Chemotherapy of chronic bronchitis and allied disorders. Second edition. London: English Universities Press, 1972."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000221889","article-title":"Visualization of doxycycline in lung tissue and sinus secretions by fluorescent techniques","volume":"21","author":"Liss, R.H.; Norman, J.C.","year":"1975","unstructured":"Liss RH, Norman JC. Visualization of doxycycline in lung tissue and sinus secretions by fluorescent techniques. Chemotherapy 1975;21:27-35.","journal-title":"Chemotherapy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000221888","article-title":"Doxycycline concentrations in lung tissue, bronchial wall and bronchial secretions","volume":"21","author":"Gartmann, J.","year":"1975","unstructured":"Gartmann J. Doxycycline concentrations in lung tissue, bronchial wall and bronchial secretions. Chemotherapy 1975;21:19-26.","journal-title":"Chemotherapy"},{"key":"ref_12","first-page":"231","article-title":"Tobramycin concentrations in human lung tissue. A study of 30 intravital lung tissue samples","volume":"6","author":"Kroening, U.; Liebig, S.; Wundschock, M.","year":"1978","unstructured":"Kroening U, Liebig S, Wundschock M. Tobramycin concentrations in human lung tissue. A study of 30 intravital lung tissue samples. Infection 1978;6:231-5.","journal-title":"Infection"},{"key":"ref_13","article-title":"Guinness MDG. An in vitro evaluation of piperacillin. Proceedings of Combined Scientific Meeting. Aust Soc Microbiol and NZ Microbiol Soc 1980: 56","author":"Burgoyne, J.; Funnell, G.R.","unstructured":"Burgoyne J, Funnell GR, Guinness MDG. An in vitro evaluation of piperacillin. Proceedings of Combined Scientific Meeting. Aust Soc Microbiol and NZ Microbiol Soc 1980:56."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1136\/thx.25.3.304","article-title":"Ampicillin levels in sputum, serum, and saliva","volume":"25","author":"Stewart, S.M.; Fisher, M.; Young, J.E.; Lutz, W.","year":"1970","unstructured":"Stewart SM, Fisher M, Young JE, Lutz W. Ampicillin levels in sputum, serum, and saliva. Thorax 1970;25: 304-11.","journal-title":"Thorax"},{"issue":"1","key":"ref_15","first-page":"10","article-title":"Amoxycillin levels in sputum, serum, and saliva","volume":"29","author":"Stewart, S.M.; Anderson, I.M.E.; Jones, G.R.; Calder, M.A.","year":"1974","unstructured":"Stewart SM, Anderson IME, Jones GR, Calder MA. Amoxycillin levels in sputum, serum, and saliva. Thorax 1974;29:1 10-4.","journal-title":"Thorax"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/thx.35.6.441","article-title":"Plasma and sputum erythromycin concentrations in patients with chronic bronchitis","volume":"35","author":"Marlin, G.E.; Davis, P.R.; Rutland, J.; Berend, N.","year":"1980","unstructured":"Marlin GE, Davis PR, Rutland J, Berend N. Plasma and sputum erythromycin concentrations in patients with chronic bronchitis. Thorax 1980;35:441-5.","journal-title":"Thorax"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1136\/jcp.23.5.427","article-title":"Tetracycline levels in bronchial secretions","volume":"23","author":"Campbell, M.J.","year":"1970","unstructured":"Campbell MJ. Tetracycline levels in bronchial secretions. J Clin Pathol 1970;23:427-34.","journal-title":"J Clin Pathol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/thx.31.2.144","article-title":"Doxycycline in serum and bronchial secretions","volume":"31","author":"Hartnett, B.J.S.; Marlin, G.E.","year":"1976","unstructured":"Hartnett BJS, Marlin GE. Doxycycline in serum and bronchial secretions. Thorax 1976;31:144-8.","journal-title":"Thorax"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0022-3476(71)80401-8","article-title":"Carbenicillin and gentamicin: pharmacological studies in patients with cystic fibrosis and pseudomonas pulmonary infections","volume":"79","author":"Marks, M.I.; Prentice, R.; Swarson, R.; Cotton, E.K.; Eickhoff, T.C.","year":"1971","unstructured":"Marks MI, Prentice R, Swarson R, Cotton EK, Eickhoff TC. Carbenicillin and gentamicin: pharmacological studies in patients with cystic fibrosis and pseudomonas pulmonary infections. J Pediatr 1971;79:822-8.","journal-title":"J Pediatr"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.36.10.774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:34:19Z","timestamp":1601112859000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.36.10.774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,10,1]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1981,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/thx.36.10.774","relation":{},"ISSN":["0040-6376"],"issn-type":[{"value":"0040-6376","type":"print"}],"subject":[],"published":{"date-parts":[[1981,10,1]]}}}