{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:44:48Z","timestamp":1770338688122,"version":"3.49.0"},"reference-count":24,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1985,6,1]]},"DOI":"10.1136\/thx.40.6.422","type":"journal-article","created":{"date-parts":[[2008,12,13]],"date-time":"2008-12-13T03:15:45Z","timestamp":1229138145000},"page":"422-426","source":"Crossref","is-referenced-by-count":57,"title":["Differences in responsiveness to hyperventilation and methacholine in asthma and chronic bronchitis."],"prefix":"10.1136","volume":"40","author":[{"given":"E H","family":"Ramsdale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F E","family":"Hargreave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"281","article-title":"Asthma induced by cold air and its relation to nonspecific bronchial responsiveness to methacholine","volume":"125","author":"PM, O.' Byrne; G, Ryan; M, Morris","year":"1982","unstructured":"O' Byrne PM, Ryan G, Morris M, et al. Asthma induced by cold air and its relation to nonspecific bronchial responsiveness to methacholine. Am Rev Respir Dis 1982; 125:281-5.","journal-title":"Am Rev Respir Dis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0091-6749(83)90521-3","article-title":"Relationship between bronchial responsiveness to hyperventilation with cold and methacholine in asthma","volume":"72","author":"Weiss, J.W.; Rossing, T.H.; jun, McFadden E.R.; jun, Ingram R.H.","year":"1983","unstructured":"Weiss JW, Rossing TH, McFadden ER jun, Ingram RH jun. Relationship between bronchial responsiveness to hyperventilation with cold and methacholine in asthma. J Allergy Clin Immunol 1983;72: 140-4.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1136\/thx.38.10.766","article-title":"Comparison of airway reactivity induced by histamine, methacholine and isocapnic hyperventilation in normal and asthmatic subjects","volume":"38","author":"Aquilina, A.T.","year":"1983","unstructured":"Aquilina AT. Comparison of airway reactivity induced by histamine, methacholine and isocapnic hyperventilation in normal and asthmatic subjects. Thorax 1983;38: 766-70.","journal-title":"Thorax"},{"key":"ref_4","first-page":"522","article-title":"Airways obstruction before and after isoprenaline, histamine, and prednisolone in patients with chronic bronchitis","volume":"i:","author":"Oppenheimer, E.A.","year":"1968","unstructured":"Oppenheimer EA. Airways obstruction before and after isoprenaline, histamine, and prednisolone in patients with chronic bronchitis. Lancet 1968;i:522-6.","journal-title":"Lancet"},{"key":"ref_5","first-page":"183","article-title":"Bronchial infection and reactivity in chronic bronchitis","volume":"2","author":"Fletcher, C.M.","year":"1968","unstructured":"Fletcher CM. Bronchial infection and reactivity in chronic bronchitis. J R Coll Physicians Lond 1968; 2:183-90.","journal-title":"J R Coll Physicians Lond"},{"key":"ref_6","first-page":"829","article-title":"Bronchial hyperreactivity in chronic obstructive bronchitis","volume":"126","author":"Ramsdell, J.W.; Machtwey, F.J.; Moser, K.M.","year":"1982","unstructured":"Ramsdell JW, Machtwey FJ, Moser KM. Bronchial hyperreactivity in chronic obstructive bronchitis. Am Rev Respir Dis 1982;126:829-32.","journal-title":"Am Rev Respir Dis"},{"key":"ref_7","first-page":"216","article-title":"Nonallergic bronchial hyperexcitability in chronic bronchitis","volume":"129","author":"Bahous, J.; Cartier, A.; Ouimet, G.; Pineau, L.; Malo, J.-L.","year":"1984","unstructured":"Bahous J, Cartier A, Ouimet G, Pineau L, Malo J-L. Nonallergic bronchial hyperexcitability in chronic bronchitis. Am Rev Respir Dis 1984; 129:216-20.","journal-title":"Am Rev Respir Dis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1136\/thx.39.12.912","article-title":"Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness","volume":"39","author":"Ramsdale, E.H.; Morris, M.M.; Roberts, R.S.; Hargreave, F.E.","year":"1984","unstructured":"Ramsdale EH, Morris MM, Roberts RS, Hargreave FE. Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness. Thorax 1984;39:912-8.","journal-title":"Thorax"},{"key":"ref_9","first-page":"57","article-title":"Spirometric standards for healthy nonsmoking adults","volume":"103","author":"Morris, J.F.; Koski, A.; Johnson, L.C.","year":"1971","unstructured":"Morris JF, Koski A, Johnson LC. Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis 1971;103:57-67.","journal-title":"Am Rev Respir Dis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/thx.33.6.705","article-title":"Reproducibility and comparison of response to inhaled methacholine","volume":"33","author":"Juniper, E.F.; Frith, P.A.; Dunnett, C.; Cockcroft, D.W.; Hargreave, F.E.","year":"1978","unstructured":"Juniper EF, Frith PA, Dunnett C, Cockcroft DW, Hargreave FE. Reproducibility and comparison of response to inhaled methacholine. Thorax 1978; 33:705-10.","journal-title":"Thorax"},{"key":"ref_11","first-page":"133","article-title":"Influence of heat and humidity on the airway obstruction induced by exercise in asthma","volume":"61","author":"Strauss, R.H.; jun, McFadden E.R.; jun, Ingram R.H.; jun, Deal E.C.; Jaeger, J.J.","year":"1978","unstructured":"Strauss RH, McFadden ER jun, Ingram RH jun, Deal EC jun, Jaeger JJ. Influence of heat and humidity on the airway obstruction induced by exercise in asthma. J Clin Invest 1978;61:133-40.","journal-title":"J Clin Invest"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0034-5687(80)90067-5","article-title":"Respiratory water loss","volume":"39","author":"Ferrus, L.; Guenard, H.; Vardon, G.; Varene, P.","year":"1980","unstructured":"Ferrus L, Guenard H, Vardon G, Varene P. Respiratory water loss. Respir Physiol 1980; 39:367-81.","journal-title":"Respir Physiol"},{"key":"ref_13","article-title":"Handbook of chemistry and physics","author":"West, R.C.","year":"1977","unstructured":"West RC. Handbook of chemistry and physics. 8th ed. Cleveland, Ohio: CRC Press, 1977.","edition":"8th ed"},{"key":"ref_14","first-page":"37","article-title":"Applied regression analysis and other multivariable methods","author":"Kleinbaum, D.G.; Kupper, L.L.","year":"1978","unstructured":"Kleinbaum DG, Kupper LL. Applied regression analysis and other multivariable methods. North Scituate, Massachusetts: Duxbury Press, 1978: 37-55."},{"key":"ref_15","first-page":"190","article-title":"Applied regression analysis and other multivariable methods","author":"Kleinbaum, D.G.; Kupper, L.L.","year":"1978","unstructured":"Kleinbaum DG, Kupper LL. Applied regression analysis and other multivariable methods. North Scituate, Massachusetts: Duxbury Press, 1978:190-2."},{"key":"ref_16","first-page":"53","article-title":"Basophil \"releasability\" in patients with asthma","volume":"122","author":"Findlay, SR, Lichtenstein; L.M.","year":"1980","unstructured":"Findlay SR, Lichtenstein LM. Basophil \"releasability\" in patients with asthma. Am Rev Respir Dis 1980; 122: 53-9.","journal-title":"Am Rev Respir Dis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/cs0610159","article-title":"Venous plasma histamine in exerciseand hyperventilation induced asthma in man","volume":"61","author":"Barnes, P.J.; Brown, M.J.","year":"1981","unstructured":"Barnes PJ, Brown MJ. Venous plasma histamine in exerciseand hyperventilation induced asthma in man. Clin Sci 1981;61:159-62.","journal-title":"Clin Sci"},{"key":"ref_18","first-page":"520","article-title":"The link between exercise, respiratory heat exchange, and the mast cell in bronchial asthma","volume":"i:","author":"Lee, R.H.; Assoufi, B.K.; Kay, A.B.","year":"1983","unstructured":"Lee RH, Assoufi BK, Kay AB. The link between exercise, respiratory heat exchange, and the mast cell in bronchial asthma. Lancet 1983;i:520-2.","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0091-6749(83)90069-6","article-title":"Asthma and increases in nonallergic bronchial responsiveness from seasonal pollen exposure","volume":"71","author":"Boulet, L.-P.; Cartier, A.; Thomson, N.C.; Roberts, R.S.; Dolovich, J.; Hargreave, F.E.","year":"1983","unstructured":"Boulet L-P, Cartier A, Thomson NC, Roberts RS, Dolovich J, Hargreave FE. Asthma and increases in nonallergic bronchial responsiveness from seasonal pollen exposure. J Allergy Clin Immunol 1983; 71: 399-406.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0091-6749(82)90038-0","article-title":"Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway calibre","volume":"70","author":"Cartier, A.; Thomson, N.C.; Frith, P.A.; Roberts, R.; Hargreave, F.E.","year":"1982","unstructured":"Cartier A, Thomson NC, Frith PA, Roberts R, Hargreave FE. Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway calibre. J Allergy Clin Immunol 1982;70: 170-7.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0007-0971(75)90090-X","article-title":"Bronchial hyperreactivity","volume":"69","author":"Benson, M.K.","year":"1975","unstructured":"Benson MK. Bronchial hyperreactivity. Br J Dis Chest 1975;69:227-39.","journal-title":"Br J Dis Chest"},{"key":"ref_22","first-page":"485","article-title":"The effects of preferential deposition of histamine in the human airway","volume":"117","author":"Ruffin, R.E.; Dolovich, M.B.; Wolff, R.K.; Newhouse, M.T.","year":"1978","unstructured":"Ruffin RE, Dolovich MB, Wolff RK, Newhouse MT. The effects of preferential deposition of histamine in the human airway. Am Rev Respir Dis 1978; 117:485-92.","journal-title":"Am Rev Respir Dis"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/thx.37.6.423","article-title":"Bronchial responsiveness to histamine: relationship to diurnal variation of peak flow rates and improvement after bronchodilators","volume":"37","author":"Ryan, G.; Latimer, K.; Dolovich, J.; Hargreave, F.E.","year":"1982","unstructured":"Ryan G, Latimer K, Dolovich J, Hargreave FE. Bronchial responsiveness to histamine: relationship to diurnal variation of peak flow rates and improvement after bronchodilators. Thorax 1982;37:423-9.","journal-title":"Thorax"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/thx.33.2.211","article-title":"Bronchial responsiveness to inhaled histamine and isoprenaline in patients with airway obstruction","volume":"33","author":"Benson, M.K.","year":"1978","unstructured":"Benson MK. Bronchial responsiveness to inhaled histamine and isoprenaline in patients with airway obstruction. Thorax 1978;33: 211-3.","journal-title":"Thorax"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.40.6.422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:01:55Z","timestamp":1601110915000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.40.6.422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,6,1]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1985,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/thx.40.6.422","relation":{},"ISSN":["0040-6376"],"issn-type":[{"value":"0040-6376","type":"print"}],"subject":[],"published":{"date-parts":[[1985,6,1]]}}}