{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:44:41Z","timestamp":1773755081868,"version":"3.50.1"},"reference-count":30,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1988,11,1]]},"DOI":"10.1136\/thx.43.11.916","type":"journal-article","created":{"date-parts":[[2008,12,13]],"date-time":"2008-12-13T03:22:59Z","timestamp":1229138579000},"page":"916-922","source":"Crossref","is-referenced-by-count":3,"title":["Bronchial responsiveness, lung mechanics, gas transfer, and corticosteroid response in patients with chronic airflow obstruction."],"prefix":"10.1136","volume":"43","author":[{"given":"A L","family":"James","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K E","family":"Finucane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A W","family":"Musk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7326\/0003-4819-96-1-17","article-title":"Steroid response in stable chronic obstructive pulmonary disease","volume":"96","author":"Mendella, L.A.; Manfreda, J.; Warren, C.P.W.; Anthonisen, N.R.","year":"1982","unstructured":"Mendella LA, Manfreda J, Warren CPW, Anthonisen NR. Steroid response in stable chronic obstructive pulmonary disease. Ann Intern Med 1982;96:17-21.","journal-title":"Ann Intern Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0091-6749(78)90137-9","article-title":"Response to corticosteroids in chronic bronchitis","volume":"62","author":"Shim, C.; Stover, D.E.; William, M.H.","year":"1978","unstructured":"Shim C, Stover DE, William MH. Response to corticosteroids in chronic bronchitis. J Allergy Clin Immunol 1978;62:363-7.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/thx.33.2.214","article-title":"A comparison of oral and inhaled steroids in patients with chronic airways obstruction: features determining response","volume":"33","author":"Harding, S.M.; Freedman, S.","year":"1978","unstructured":"Harding SM, Freedman S. A comparison of oral and inhaled steroids in patients with chronic airways obstruction: features determining response. Thorax 1978; 33:214-8.","journal-title":"Thorax"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1136\/bmj.2.5371.1509","article-title":"Bronchodilators and corticosteroids in chronic bronchitis and emphysema","volume":"ii:","author":"Freedman, B.J.","year":"1963","unstructured":"Freedman BJ. Bronchodilators and corticosteroids in chronic bronchitis and emphysema. Br Med J 1963;ii: 1509-12.","journal-title":"Br Med J"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1056\/NEJM196301312680502","article-title":"A controlled study of the effect of prednisone on airflow obstruction in severe pulmonary emphysema","volume":"268","author":"Beerel, F.; Jick, H.; Tyler, J.M.","year":"1963","unstructured":"Beerel F, Jick H, Tyler JM. A controlled study of the effect of prednisone on airflow obstruction in severe pulmonary emphysema. N Engl J Med 1963;268: 226-30.","journal-title":"N Engl J Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0007-0971(83)90027-X","article-title":"Response to oral corticosteroids in chronic airflow obstruction","volume":"77","author":"Lam, W.K.; So, S.Y.; Yu, D.Y.C.","year":"1983","unstructured":"Lam WK, So SY, Yu DYC. Response to oral corticosteroids in chronic airflow obstruction. Br J Dis Chest 1983;77:189-98.","journal-title":"Br J Dis Chest"},{"key":"ref_7","first-page":"774","article-title":"Bronchodilators and corticosteroids in the treatment of obstructive pulmonary emphysema","volume":"238","author":"Franklin, W.; Michelson, A.L.; Lowel, F.C.; Schilten, I.W.","year":"1958","unstructured":"Franklin W, Michelson AL, Lowel FC, Schilten IW. Bronchodilators and corticosteroids in the treatment of obstructive pulmonary emphysema. N Engl J Med 1958;238:774-7.","journal-title":"N Engl J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.7326\/0003-4819-61-2-248","article-title":"A controlled trial of the effect of steroids in obstructive airway disease","volume":"61","author":"Morgan, W.K.C.; Rusche, E.","year":"1964","unstructured":"Morgan WKC, Rusche E. A controlled trial of the effect of steroids in obstructive airway disease. Ann Intern Med 1964;61:248-54.","journal-title":"Ann Intern Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0140-6736(68)92829-8","article-title":"Airways obstruction before and after isoprenaline, histamine and prednisone in patients with chronic obstructive bronchitis","volume":"i:","author":"Oppenheimer, E.A.; Rigatto, M.; Fletcher, G.M.","year":"1968","unstructured":"Oppenheimer EA, Rigatto M, Fletcher GM. Airways obstruction before and after isoprenaline, histamine and prednisone in patients with chronic obstructive bronchitis. Lancet 1968;i:552-7.","journal-title":"Lancet"},{"key":"ref_10","first-page":"695","article-title":"Bronchial hyperreactivity in corticosteroid responsive patients with chronic airflow obstruction","volume":"39","author":"Gove, R.I.; Shepherd, J.; Burge, P.S.","year":"1984","unstructured":"Gove RI, Shepherd J, Burge PS. Bronchial hyperreactivity in corticosteroid responsive patients with chronic airflow obstruction [abstract]. Thorax 1984; 39:695."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1378\/chest.86.4.524","article-title":"Treatment of chronic obstructive pulmonary disease with corticosteroids. Comparison ofdaily vs alternate-day therapy","volume":"86","author":"Blair, G.P.; Light, R.N.","year":"1984","unstructured":"Blair GP, Light RN. Treatment of chronic obstructive pulmonary disease with corticosteroids. Comparison ofdaily vs alternate-day therapy. Chest 1984;86:524-8.","journal-title":"Chest"},{"key":"ref_12","first-page":"17","article-title":"Corticosteroids in chronic bronchitis and pulmonary emphysema","volume":"96","author":"Sahn, S.A.","year":"1982","unstructured":"Sahn SA. Corticosteroids in chronic bronchitis and pulmonary emphysema. Ann Intern Med 1982;96: 17-21.","journal-title":"Ann Intern Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1136\/bmj.288.6430.1553","article-title":"Corticosteroids in chronic bronchitis","volume":"288","author":"Rudd, R.","year":"1984","unstructured":"Rudd R. Corticosteroids in chronic bronchitis. Br Med J 1984;288:1553-4.","journal-title":"Br Med J"},{"key":"ref_14","first-page":"79","article-title":"Pathological changes in asthma","author":"Reid, L.","year":"1977","unstructured":"Reid L. Pathological changes in asthma. In: Clark TJH, Godfrey S, eds. Asthma. London: Chapman and Hall, 1977:79-95."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/jappl.1973.34.2.143","article-title":"Pulmonary conductance and elastic recoil relationships in asthma and emphysema","volume":"34","author":"Colebatch, H.J.H.; Finucane, K.E.; Smith, M.M.","year":"1973","unstructured":"Colebatch HJH, Finucane KE, Smith MM. Pulmonary conductance and elastic recoil relationships in asthma and emphysema. J Appl Physiol 1973;34:143-53.","journal-title":"J Appl Physiol"},{"key":"ref_16","first-page":"330","article-title":"Elastic behaviour of the lung in patients with airway obstruction","volume":"26","author":"Finucane, K.E.; Colebatch, H.J.H.","year":"1969","unstructured":"Finucane KE, Colebatch HJH. Elastic behaviour of the lung in patients with airway obstruction. JApplPhysiol 1969;26:330-8.","journal-title":"JApplPhysiol"},{"key":"ref_17","first-page":"119","article-title":"Correlation between the function and structure of the lungs in smokers","author":"Berend, N.C.; Woolcock, A.J.; Marlin, G.E.","year":"1979","unstructured":"Berend NC, Woolcock AJ, Marlin GE. Correlation between the function and structure of the lungs in smokers. Am Rev Respir Dis 1979;119.695-705.","journal-title":"Am Rev Respir Dis"},{"key":"ref_18","first-page":"389","article-title":"Bronchial hyperreactivity","volume":"121","author":"Boushey, H.A.; Holtzman, M.J.; Sheller, JR, Nadel; J.A.","year":"1980","unstructured":"Boushey HA, Holtzman MJ, Sheller JR, Nadel JA. Bronchial hyperreactivity. Am Rev Respir Dis 1980; 121:389-413.","journal-title":"Am Rev Respir Dis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0091-6749(81)90132-9","article-title":"Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance","volume":"68","author":"Hargreave, F.E.; Ryan, G.; Thomson, N.C.","year":"1981","unstructured":"Hargreave FE, Ryan G, Thomson NC, et al. Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol 1981;68:347-55.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1136\/thx.39.12.912","article-title":"Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness","volume":"39","author":"Ramsdale, E.H.; Morris, M.M.; Roberts, R.S.; Hargreave, F.E.","year":"1984","unstructured":"Ramsdale EH, Morris MM, Roberts RS, Hargreave FE. Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness. Thorax 1984;39:912-8.","journal-title":"Thorax"},{"key":"ref_21","first-page":"25","article-title":"Prevalence and nature of bronchial hyperresponsiveness in subjects with chronic obstructive pulmonary disease","volume":"132","author":"Yan, C.; Salome, C.M.; Woolcock, A.J.","year":"1985","unstructured":"Yan C, Salome CM, Woolcock AJ. Prevalence and nature of bronchial hyperresponsiveness in subjects with chronic obstructive pulmonary disease. Am Rev Respir Dis 1985;132:25-9.","journal-title":"Am Rev Respir Dis"},{"key":"ref_22","first-page":"380","article-title":"Lung function. Assessment and application in medicine","author":"Cotes, J.E.","year":"1975","unstructured":"Cotes JE. Lung function. Assessment and application in medicine. 3rd ed. Oxford: Blackwell Scientific Publications, 1975:380-1.","edition":"3rd ed"},{"key":"ref_23","article-title":"Committee on the Aetiology of Chronic Bronchitis. Standardised questionnaire on respiratory symptoms","author":"Medical Research Council","year":"1960","unstructured":"Medical Research Council Committee on the Aetiology of Chronic Bronchitis. Standardised questionnaire on respiratory symptoms. Br Med J 1960;ii: 1965.","journal-title":"Br Med J"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ije\/3.2.135","article-title":"The application of a quantitative estimate of cough frequency to epidemiological surveys","volume":"3","author":"Field, G.B.","year":"1974","unstructured":"Field GB. The application of a quantitative estimate of cough frequency to epidemiological surveys. Int J Epidemiol 1974;3:135-43.","journal-title":"Int J Epidemiol"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1172\/JCI103281","article-title":"A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects","volume":"35","author":"DuBois, A.B.; Botelho, H.Y.; Bedell, G.N.; Marshall, R.; JH, Jr, Comroe","year":"1956","unstructured":"DuBois AB, Botelho HY, Bedell GN, Marshall R, Comroe JH Jr. A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects. J Clin Invest 1956;35:322-6.","journal-title":"J Clin Invest"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1152\/jappl.1975.38.3.531","article-title":"Estimation of alveolar pressure during forced oscillation of the respiratory system","volume":"38","author":"Finucane, K.E.; Mead, J.","year":"1975","unstructured":"Finucane KE, Mead J. Estimation of alveolar pressure during forced oscillation of the respiratory system. J Appl Physiol 1975;38:531-7.","journal-title":"J Appl Physiol"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/jappl.1964.19.2.207","article-title":"Improved technique for estimating pleural pressure from oesophageal balloons","volume":"19","year":"1964","unstructured":"Improved technique for estimating pleural pressure from oesophageal balloons. J Appl Physiol 1964;19: 207-11.","journal-title":"J Appl Physiol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1152\/jappl.1979.47.4.683","article-title":"Exponential analysis ofelastic recoil and aging in healthy males and females","volume":"47","author":"Colebatch, H.J.H.; Greaves, I.A.; Ng, C.K.Y.","year":"1979","unstructured":"Colebatch HJH, Greaves IA, Ng CKY. Exponential analysis ofelastic recoil and aging in healthy males and females. J Appl Physiol 1979;47:683-91.","journal-title":"J Appl Physiol"},{"key":"ref_29","first-page":"623","article-title":"Prednisolone pharmacokinetics in children with nephrotic syndrome: studies in relapse and remission","volume":"6","author":"Potter, J.M.; Bower, G.D.","year":"1981","unstructured":"Potter JM, Bower GD. Prednisolone pharmacokinetics in children with nephrotic syndrome: studies in relapse and remission. Clin Exp Pharmacol Physiol 1981;6: 623-4.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref_30","first-page":"484","article-title":"Corticosteroids in COPD. A clinical trial and reassessment of the literature","volume":"4","year":"1986","unstructured":"Eliasson 0, Hoffman J, Trueb D, Frederick D, McCormick JR. Corticosteroids in COPD. A clinical trial and reassessment of the literature. Chest 1986;4: 484-90.","journal-title":"Chest"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.43.11.916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:06:05Z","timestamp":1601111165000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.43.11.916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11,1]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1988,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/thx.43.11.916","relation":{},"ISSN":["0040-6376"],"issn-type":[{"value":"0040-6376","type":"print"}],"subject":[],"published":{"date-parts":[[1988,11,1]]}}}