{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:43:04Z","timestamp":1774122184481,"version":"3.50.1"},"reference-count":36,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1991,7,1]]},"DOI":"10.1136\/thx.46.7.488","type":"journal-article","created":{"date-parts":[[2008,12,13]],"date-time":"2008-12-13T03:22:59Z","timestamp":1229138579000},"page":"488-492","source":"Crossref","is-referenced-by-count":106,"title":["Exercise but not methacholine differentiates asthma from chronic lung disease in children."],"prefix":"10.1136","volume":"46","author":[{"given":"S","family":"Godfrey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Springer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Noviski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Maayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Avital","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/bmj.4.5679.321","article-title":"Prevalence, natural history and relationship of wheezy bronchitis and asthma in children. An epidemiological study","volume":"iv:","author":"Williams, H.; McNicol, K.N.","year":"1969","unstructured":"Williams H, McNicol KN. Prevalence, natural history and relationship of wheezy bronchitis and asthma in children. An epidemiological study. BMJ 1969;iv:321-5.","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1136\/bmj.286.6373.1256","article-title":"Prevalence and spectrum of asthma in childhood","volume":"286","author":"Lee, D.A.; Winslow, N.R.; Speight, A.N.; Hey, E.N.","year":"1983","unstructured":"Lee DA, Winslow NR, Speight AN, Hey EN. Prevalence and spectrum of asthma in childhood. BMJ 1983;286: 1256-8.","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/bmj.286.6373.1253","article-title":"Underdiagnosis and undertreatment of asthma in childhood","volume":"286","author":"Speight, A.N.P.; Lee, D.A.; Hey, E.N.","year":"1983","unstructured":"Speight ANP, Lee DA, Hey EN. Underdiagnosis and undertreatment of asthma in childhood. BMJ 1983;286:1253-6.","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1164\/ajrccm\/138.3.524","article-title":"International comparison of the prevalence of asthma symptoms and bronchial hyperresponsiveness","volume":"138","author":"Asher, M.I.; Pattemore, P.K.; Harrison, A.C.","year":"1988","unstructured":"Asher MI, Pattemore PK, Harrison AC, et al. International comparison of the prevalence of asthma symptoms and bronchial hyperresponsiveness. Am Rev Respir Dis 1988;138:524-9.","journal-title":"Am Rev Respir Dis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1542\/peds.84.1.111","article-title":"Hospitalization for children with status asthmaticus: A review","volume":"84","author":"Richards, W.","year":"1989","unstructured":"Richards W. Hospitalization for children with status asthmaticus: A review. Pediatrics 1989;84:111-8.","journal-title":"Pediatrics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/archinte.1965.03860160078013","article-title":"Methacholine aerosol as test for bronchial asthma","volume":"115","author":"Parker, C.D.; Bilbo, R.E.; Reed, C.E.","year":"1965","unstructured":"Parker CD, Bilbo RE, Reed CE. Methacholine aerosol as test for bronchial asthma. Arch Intern Med 1965;115:452-8.","journal-title":"Arch Intern Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0091-6749(79)90014-9","article-title":"Methacholine inhalation challenge studies","volume":"64","author":"Townley, R.G.; Bewtra, A.K.; Nair, N.M.; Brodky, F.D.; Watt, G.D.; Burke, K.M.","year":"1979","unstructured":"Townley RG, Bewtra AK, Nair NM, Brodky FD, Watt GD, Burke KM. Methacholine inhalation challenge studies. J Allergy Clin Immunol 1979;64:569-74.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/thx.36.8.575","article-title":"Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma","volume":"36","author":"Juniper, E.F.; Frith, P.A.; Hargreave, F.E.","year":"1981","unstructured":"Juniper EF, Frith PA, Hargreave FE. Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax 1981;36:575-9.","journal-title":"Thorax"},{"key":"ref_9","first-page":"297","article-title":"Stimuli to bronchoconstriction-basic mechanisms","volume":"18","author":"Godfrey, S.","year":"1982","unstructured":"Godfrey S. Stimuli to bronchoconstriction-basic mechanisms. Israel J Med Sci 1982;18:297-306.","journal-title":"Israel J Med Sci"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/thx.38.4.284","article-title":"Evaluation of ultrasonically nebulised solutions for provocation testing in patients with asthma","volume":"38","author":"Anderson, S.D.; Schoeffel, R.E.; Finney, M.","year":"1983","unstructured":"Anderson SD, Schoeffel RE, Finney M. Evaluation of ultrasonically nebulised solutions for provocation testing in patients with asthma. Thorax 1983;38:284-91.","journal-title":"Thorax"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1378\/chest.84.1.42","article-title":"Diagnosis of bronchial asthma by clinical evaluation. An unreliable method","volume":"84","author":"Pratter, M.R.; Hingston, D.M.; Irwin, R.S.","year":"1983","unstructured":"Pratter MR, Hingston DM, Irwin RS. Diagnosis of bronchial asthma by clinical evaluation. An unreliable method. Chest 1983;84:42-7.","journal-title":"Chest"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/adc.50.6.477","article-title":"Prevalence of atopy and exerciseinduced bronchial lability in relatives of patients with cystic fibrosis","volume":"50","author":"Counahan, R.; Mearns, M.B.","year":"1975","unstructured":"Counahan R, Mearns MB. Prevalence of atopy and exerciseinduced bronchial lability in relatives of patients with cystic fibrosis. Arch Dis Child 1975;50:477-81.","journal-title":"Arch Dis Child"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2222.1979.tb00480.x","article-title":"Response to bronchial provocation and exercise in children with cystic fibrosis","volume":"9","author":"Price, J.F.; Weller, P.H.; Harper, S.A.; Matthew, D.J.","year":"1979","unstructured":"Price JF, Weller PH, Harper SA, Matthew DJ. Response to bronchial provocation and exercise in children with cystic fibrosis. Clin Allergy 1979;9:563-70.","journal-title":"Clin Allergy"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1651-2227.1976.tb04405.x","article-title":"Bronchial lability in cystic fibrosis","volume":"65","author":"Skorecki, K.; Levison, H.; Crozier, D.N.","year":"1976","unstructured":"Skorecki K, Levison H, Crozier DN. Bronchial lability in cystic fibrosis. Acta Paediatr Scand 1976;65:39-44.","journal-title":"Acta Paediatr Scand"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/adc.56.6.455","article-title":"Variability of airways hyperreactivity and allergy in cystic fibrosis","volume":"56","author":"Holzer, F.J.; Olinsky, A.; Phelan, P.D.","year":"1981","unstructured":"Holzer FJ, Olinsky A, Phelan PD. Variability of airways hyperreactivity and allergy in cystic fibrosis. Arch Dis Child 1981;56:455-9.","journal-title":"Arch Dis Child"},{"key":"ref_16","first-page":"233","article-title":"Does measurement of bronchial hyperreactivity help in clinical diagnosis of asthma","volume":"68","author":"Britton, J.; Tattersfield, A.E.","year":"1986","unstructured":"Britton J, Tattersfield AE. Does measurement of bronchial hyperreactivity help in clinical diagnosis of asthma. Eur J Respir Dis 1986;68:233-8.","journal-title":"Eur J Respir Dis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1136\/thx.39.12.912","article-title":"Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness","volume":"39","author":"Ramsdale, E.H.; Morris, M.M.; Roberts, R.S.; Hargreave, F.E.","year":"1984","unstructured":"Ramsdale EH, Morris MM, Roberts RS, Hargreave FE. Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness. Thorax 1984;39:912-8.","journal-title":"Thorax"},{"key":"ref_18","article-title":"Differences in responsiveness to hyperventilation and methacholine in asthma and chronic bronchitis. Thorax 1985; 40: 422-6. i9 Cockcroft DW","author":"Ramsdale, E.H.; Roberts, R.S.; Morris, M.M.; Hargreave, F.E.","unstructured":"Ramsdale EH, Roberts RS, Morris MM, Hargreave FE. Differences in responsiveness to hyperventilation and methacholine in asthma and chronic bronchitis. Thorax 1985;40:422-6. i9 Cockcroft DW, Killian DM, Mellon JJA, Hargreave FE."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0007-0971(75)90053-4","article-title":"Exerciseinduced asthma","volume":"69","author":"Anderson, S.D.; Silverman, M.; Konig, P.; Godfrey, S.","year":"1975","unstructured":"Anderson SD, Silverman M, Konig P, Godfrey S. Exerciseinduced asthma. Br J Dis Chest 1975;69:1-39.","journal-title":"Br J Dis Chest"},{"key":"ref_20","first-page":"911","article-title":"Comparative study of histamine and exercise challenges in asthmatic children","volume":"117","author":"Mellis, C.M.; Kattan, M.; Keens, T.G.; Levison, H.","year":"1978","unstructured":"Mellis CM, Kattan M, Keens TG, Levison H. Comparative study of histamine and exercise challenges in asthmatic children. Am Rev Respir Dis 1978;117:911-5.","journal-title":"Am Rev Respir Dis"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/ppul.1950040103","article-title":"Determination of airway hyperreactivity in asthmatic children: A comparison among exercise, nebulised water and histamine challenges","volume":"4","author":"Fourie, P.R.; Joubert, JR","year":"1988","unstructured":"Fourie PR, Joubert JR. Determination of airway hyperreactivity in asthmatic children: A comparison among exercise, nebulised water and histamine challenges. Pediatr Pulmonol 1988;4:2-7.","journal-title":"Pediatr Pulmonol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1542\/peds.67.4.508","article-title":"Effectiveness of terbutaline and theophylline alone and in combination in exerciseinduced bronchospasm","volume":"67","author":"Shapiro, G.; Phillips, J.J.; Smith, K.; Furukawa, C.T.; Pierson, W.E.; Bierman, C.W.","year":"1981","unstructured":"Shapiro G, Phillips JJ, Smith K, Furukawa CT, Pierson WE, Bierman CW. Effectiveness of terbutaline and theophylline alone and in combination in exerciseinduced bronchospasm. Pediatrics 1981;67:508-13.","journal-title":"Pediatrics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/bmj.291.6490.248-a","article-title":"Effect of inhalation of corticosteroids on exercise induced asthma: randomised double blind crossover study of budesonide in asthmatic children","volume":"291","author":"Henriksen, J.M.","year":"1985","unstructured":"Henriksen JM. Effect of inhalation of corticosteroids on exercise induced asthma: randomised double blind crossover study of budesonide in asthmatic children. BMJ 1985;291:248-9.","journal-title":"BMJ"},{"issue":"1","key":"ref_24","first-page":"163","article-title":"Theophylline has a doserelated effect on the airway response to inhaled histamine and methacholine in asthmatics","volume":"136","author":"Magnussen, H.; Reuss, G.; Jorres, R.","year":"1987","unstructured":"Magnussen H, Reuss G, Jorres R. Theophylline has a doserelated effect on the airway response to inhaled histamine and methacholine in asthmatics. Am Rev Respir Dis 1987;136:1 163-7.","journal-title":"Am Rev Respir Dis"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/thx.43.5.378","article-title":"Effect of prednisone and beclomethasone dipropionate on airway responsiveness in asthma: a comparative study","volume":"43","author":"Jenkins, C.R.; Woolcock, A.J.","year":"1988","unstructured":"Jenkins CR, Woolcock AJ. Effect of prednisone and beclomethasone dipropionate on airway responsiveness in asthma: a comparative study. Thorax 1988;43:378-84.","journal-title":"Thorax"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/0091-6749(90)90194-9","article-title":"Relationship of different serum levels of theophylline on methacholine sensitivity","volume":"85","author":"Tinkelman, D.G.; Bikramjit, S.G.; Lutz, C.N.","year":"1990","unstructured":"Tinkelman DG, Bikramjit SG, Lutz CN. Relationship of different serum levels of theophylline on methacholine sensitivity. J Allergy Clin Immunol 1990;85:750-5.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_27","first-page":"215","article-title":"Exercise-induced asthma: a difference in opinion regarding","volume-title":"the stimulus. Allergy Proc 1989; 10","author":"Anderson, S.D.; Daviskas, E.; Smith, C.M.","unstructured":"Anderson SD, Daviskas E, Smith CM. Exercise-induced asthma: a difference in opinion regarding the stimulus. Allergy Proc 1989;10:215-26."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0140-6736(90)90478-N","article-title":"Hypothesis: exercise-induced asthma as a vascular phenomenon","volume":"335","author":"McFadden, E.R.","year":"1990","unstructured":"McFadden ER. Hypothesis: exercise-induced asthma as a vascular phenomenon. Lancet 1990;335:880-3.","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/0140-6736(90)91297-N","article-title":"Exercise-induced asthma as a vascular phenomenon","volume":"335","author":"Godfrey, S.","year":"1990","unstructured":"Godfrey S. Exercise-induced asthma as a vascular phenomenon [Letter]. Lancet 1990;335:1410-1.","journal-title":"Lancet"},{"key":"ref_30","first-page":"81","article-title":"Controversies in the pathogenesis of exercise induced asthma: Annotation","volume":"68","author":"Godfrey, S.","year":"1986","unstructured":"Godfrey S. Controversies in the pathogenesis of exercise induced asthma: Annotation. Eur J Respir Dis 1986;68: 81-8.","journal-title":"Eur J Respir Dis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0091-6749(82)90232-9","article-title":"Exercise induced release of histamine and neutrophil chemotactic factor in atopic asthmatics","volume":"70","author":"Lee, T.J.; Brown, M.J.; Nagy, L.; Causon, R.; Walport, M.J.; Kay, A.B.","year":"1982","unstructured":"Lee TJ, Brown MJ, Nagy L, Causon R, Walport MJ, Kay AB. Exercise induced release of histamine and neutrophil chemotactic factor in atopic asthmatics. J Allergy Clin Immunol 1982;70:73-81.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1172\/JCI110528","article-title":"Identification and partial characterization of an exerciseinduced neutrophil chemotatic factor in bronchial asthma","volume":"69","author":"Lee, T.H.; Nagy, L.; Nakagura, T.; Walport, M.J.; Kay, A.B.","year":"1982","unstructured":"Lee TH, Nagy L, Nakagura T, Walport MJ, Kay AB. Identification and partial characterization of an exerciseinduced neutrophil chemotatic factor in bronchial asthma. J Clin Invest 1982;69:889-99.","journal-title":"J Clin Invest"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0091-6749(86)90226-5","article-title":"The origin of airway hyperresponsiveness","volume":"78","author":"Hargreave, F.E.; Dolovich, J.; O'Byrne, P.M.; Ramsdale, E.H.; Daniel, E.E.","year":"1986","unstructured":"Hargreave FE, Dolovich J, O'Byrne PM, Ramsdale EH, Daniel EE. The origin of airway hyperresponsiveness. J Allergy Clin Immunol 1986;78:825-32.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0091-6749(89)90441-7","article-title":"New concepts in the pathogenesis of bronchial hyperresponsiveness and asthma","volume":"83","author":"Barnes, P.J.","year":"1989","unstructured":"Barnes PJ. New concepts in the pathogenesis of bronchial hyperresponsiveness and asthma. J Allergy Clin Immunol 1989;83:1013-26.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_35","first-page":"609","article-title":"Lung function in young adults who had asthma in childhood","volume":"122","author":"Martin, A.J.; Landau, L.I.; Phelan, P.D.","year":"1980","unstructured":"Martin AJ, Landau LI, Phelan PD. Lung function in young adults who had asthma in childhood. Am Rev Respir Dis 1980;122:609-16.","journal-title":"Am Rev Respir Dis"},{"key":"ref_36","first-page":"235","article-title":"A comparison of histamine, methacholine and exercise airway reactivity in control and asthmatic subjects","volume":"126","author":"Chatham, M.; Bleecher, E.R.; Smith, P.L.; Rosenthal, R.R.; Mason, P.; Norman, P.S.","year":"1982","unstructured":"Chatham M, Bleecher ER, Smith PL, Rosenthal RR, Mason P, Norman PS. A comparison of histamine, methacholine and exercise airway reactivity in control and asthmatic subjects. Am Rev Respir Dis 1982;126:235-40.","journal-title":"Am Rev Respir Dis"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.46.7.488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T22:38:34Z","timestamp":1684795114000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.46.7.488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7,1]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/thx.46.7.488","relation":{},"ISSN":["0040-6376"],"issn-type":[{"value":"0040-6376","type":"print"}],"subject":[],"published":{"date-parts":[[1991,7,1]]}}}