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A controlled clinical trial. Arthr reports that pulmonary toxicity may not recur after rechallenge remain to be explained.16 17 Rheum 1985;28:721-730."},{"key":"ref_3","article-title":"Methotrexate-induced pneumonitis. Medicine 1976; As methotrexate has been shown to 55: 371-88. accumulate preferentially in the lung, i8 and","author":"Sostman, H.D.; Matthey, R.A.; Putman, C.E.; Walker-Smith, G.J.","unstructured":"Sostman HD, Matthey RA, Putman CE, Walker-Smith GJ. Methotrexate-induced pneumonitis. Medicine 1976; As methotrexate has been shown to 55:371-88. accumulate preferentially in the lung,i8 and"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/art.1780261015","article-title":"Acute lung disease associated with low-dose clinical resolution may follow dose reduction,19 pulse methotrexate therapy in patients with rheumatoid it has been suggested that a direct cytotoxic action may be important in some instances.4 arthritis","volume":"26","year":"1983","unstructured":"Cannon GW, Ward JR, Clegg DO, Samuelson CO Jr, Abbott TM. Acute lung disease associated with low-dose clinical resolution may follow dose reduction,19 pulse methotrexate therapy in patients with rheumatoid it has been suggested that a direct cytotoxic action may be important in some instances.4 arthritis. Arthr Rheum 1983;26:1269-74.","journal-title":"Arthr Rheum"},{"key":"ref_5","first-page":"1275","article-title":"Methotrexate pneumonitis after low-dose therapy for rheumatoid ar- Acute pulmonary toxicity appears, however, to be unrelated to either the dose or the duration of treatment. One important variable appears thritis","volume":"26","author":"Engelbrecht, J.A.; Calhoon, S.L.; Scherrer, J.J.","year":"1983","unstructured":"Engelbrecht JA, Calhoon SL, Scherrer JJ. Methotrexate pneumonitis after low-dose therapy for rheumatoid ar- Acute pulmonary toxicity appears, however, to be unrelated to either the dose or the duration of treatment. One important variable appears thritis. 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Semin Arthr Rheum 1984;13:235-43.","journal-title":"Semin Arthr Rheum"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/archinte.1985.00360110105023","article-title":"Pneumonitis complihave a higher risk of toxicity than those receivcating low-dose methotrexate therapy in rheumatoid ing the drug less frequently.20 arthritis","volume":"145","author":"St Clair EW, Rice JR, Synderman R","year":"1985","unstructured":"St Clair EW, Rice JR, Synderman R. Pneumonitis complihave a higher risk of toxicity than those receivcating low-dose methotrexate therapy in rheumatoid ing the drug less frequently.20 arthritis. Arch Intern Med 1985;145:2035-8.","journal-title":"Arch Intern Med"},{"issue":"16 23","key":"ref_9","first-page":"232","article-title":"Comparative study ment period extending over three years. 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Chest 1982;82(suppl):232.","journal-title":"Chest; The five cases described here are derived from a cohort of 43 patients prescribed of T-cell subsets in BAL fluid in patients with hypersensitivity pneumonitis and sarcoidosis"},{"key":"ref_10","first-page":"569","article-title":"Broncho-alveolar lavage in gold lung","volume":"85","author":"Ettensohn, D.B.; Roberts, N.J.; Condemi, J.J.","year":"1984","unstructured":"Ettensohn DB, Roberts NJ, Condemi JJ. Broncho-alveolar lavage in gold lung. Chest 1984;85:569-70.","journal-title":"Chest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1378\/chest.91.1.96","article-title":"Leucocyte migration inhibition in methlow dose methotrexate over the previous three otrexate-induced pneumonitis","volume":"91","author":"Akoun, G.M.; Gauthier-Rahman, S.; Mayaud, C.M.; Touboul, J.L.; Denis, M.F.","year":"1987","unstructured":"Akoun GM, Gauthier-Rahman S, Mayaud CM, Touboul JL, Denis MF. Leucocyte migration inhibition in methlow dose methotrexate over the previous three otrexate-induced pneumonitis. Chest 1987;91:96-9. years, representing an overall incidence of","journal-title":"Chest"},{"key":"ref_12","first-page":"186","article-title":"Pulmonary disease during the treatment of rheumatoid almost 12%. The Committee on Safety of arthritis with low dose pulse methotrexate. Semin Arthr Medicines (personal communication) has received eight reports of pneumonitis Rheum","volume":"16","author":"Carson, C.W.; Cannon, G.W.; Egger, M.J.; Ward, JR, Clegg; D.O.","year":"1987","unstructured":"Carson CW, Cannon GW, Egger MJ, Ward JR, Clegg DO. Pulmonary disease during the treatment of rheumatoid almost 12%. The Committee on Safety of arthritis with low dose pulse methotrexate. 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