{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:38:08Z","timestamp":1774665488417,"version":"3.50.1"},"reference-count":55,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1993,4,1]]},"DOI":"10.1136\/thx.48.4.396","type":"journal-article","created":{"date-parts":[[2008,12,13]],"date-time":"2008-12-13T03:22:59Z","timestamp":1229138579000},"page":"396-400","source":"Crossref","is-referenced-by-count":41,"title":["A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: a hypothesis."],"prefix":"10.1136","volume":"48","author":[{"given":"J A","family":"Karlsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1113\/jphysiol.1965.sp007660","article-title":"Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs","volume":"179","author":"Coleridge, H.M.; Coleridge, J.C.G.; Luck, J.C.","year":"1965","unstructured":"Coleridge HM, Coleridge JCG, Luck JC. Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs. J Physiol (Lond) 1965;179:248-62.","journal-title":"J Physiol (Lond)"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1152\/jappl.1988.65.3.1007","article-title":"Afferent neural pathways in cough and reflex bronchoconstriction","volume":"65","author":"Karlsson, J.-A.; Sant'Ambrogio, G.; Widdicombe, J.G.","year":"1988","unstructured":"Karlsson J-A, Sant'Ambrogio G, Widdicombe JG. Afferent neural pathways in cough and reflex bronchoconstriction. JAppl Physiol 1988;65:1007-23.","journal-title":"JAppl Physiol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/302251a0","article-title":"Capsaicin induced desensitization of the airway mucosa to cigarette smoke, mechanical and chemical irritants","volume":"302","author":"Lundberg, J.M.; Saria, A.","year":"1983","unstructured":"Lundberg JM, Saria A. Capsaicin induced desensitization of the airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature 1983;302:251-3.","journal-title":"Nature"},{"key":"ref_4","first-page":"634","article-title":"Evidence against vasoactive intestinal polypeptide (VIP) as a dilator and in favour of substance P as a constrictor in airway neurogenic responses","volume":"79","author":"Karlsson, J.-A.; Persson, C.G.A.","year":"1983","unstructured":"Karlsson J-A, Persson CGA. Evidence against vasoactive intestinal polypeptide (VIP) as a dilator and in favour of substance P as a constrictor in airway neurogenic responses. BrJPharmacol 1983;79:634-6.","journal-title":"BrJPharmacol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1164\/ajrccm\/144.5.1187","article-title":"Neuropeptides in the respiratory tract","volume":"144","author":"Barnes, P.; Baraniuk, J.N.; Belvisi, M.G.","year":"1991","unstructured":"Barnes P, Baraniuk JN, Belvisi MG. Neuropeptides in the respiratory tract. Am Rev Respir Dis 1991;144:1187-98, 1391-9.","journal-title":"Am Rev Respir Dis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0163-7258(89)90018-1","article-title":"Novel peripheral neurotransmitters and control of the airways","volume":"43","author":"Karlsson, J.-A.; Persson, C.G.A.","year":"1989","unstructured":"Karlsson J-A, Persson CGA. Novel peripheral neurotransmitters and control of the airways. Pharnac Ther 1989; 43:397-423.","journal-title":"Pharnac Ther"},{"key":"ref_7","first-page":"6790","article-title":"et al Characterisation of neurokinin effects and receptor selectivity in human isolated bronchi","volume":"140","author":"Naline, E.; Devillier, P.; Drapeau, G.; Toty, L.; Bakdach, H.; Regoli, D.","year":"1989","unstructured":"Naline E, Devillier P, Drapeau G, Toty L, Bakdach H, Regoli D, et al Characterisation of neurokinin effects and receptor selectivity in human isolated bronchi. Am Rev RespirDis 1989;140:6790-86.","journal-title":"Am Rev RespirDis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1476-5381.1985.tb08827.x","article-title":"Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation","volume":"85","author":"Finney, M.J.B.; Karlsson, J.-A.; Persson, C.G.A.","year":"1985","unstructured":"Finney MJB, Karlsson J-A, Persson CGA. Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. Br J Pharmacol 1985;85: 29-36.","journal-title":"Br J Pharmacol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/thx.42.10.779","article-title":"Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects","volume":"42","author":"Joos, G.; Pauwels, R.; Van Der Straeten, M.","year":"1987","unstructured":"Joos G, Pauwels R, Van Der Straeten M. Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. Thorax 1987;42:779-83.","journal-title":"Thorax"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1183\/09031936.93.04060673","article-title":"Substance P immunoreactive nerves in airways from asthmatics and non-asthmatics","volume":"4","author":"Ollerenshaw, S.L.; Jarvis, D.L.; Sullivan, C.E.; Woolcock, A.J.","year":"1991","unstructured":"Ollerenshaw SL, Jarvis DL, Sullivan CE, Woolcock AJ. Substance P immunoreactive nerves in airways from asthmatics and non-asthmatics. Eur Respir 1991;4: 673-82.","journal-title":"Eur Respir"},{"key":"ref_11","first-page":"835","article-title":"et al NK, receptor gene expression is increased in asthmativc lung and reduced by corticosteroids","volume":"145","author":"Peters, M.J.; IM, Adcock; Gelder, C.M.; H, Shimasaki; MG, Belvisi; M, Yacoub","year":"1992","unstructured":"Peters, MJ, Adcock IM, Gelder, CM, Shimasaki H, Belvisi MG, Yacoub M, et al NK, receptor gene expression is increased in asthmativc lung and reduced by corticosteroids [abstract]. Am Rev Respir Dis 1992;145: A835.","journal-title":"Am Rev Respir Dis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0140-6736(86)90777-4","article-title":"Asthma as an axon reflex","author":"Barnes, P.J.","year":"1986","unstructured":"Barnes PJ. Asthma as an axon reflex. Lancet 1986:242-4.","journal-title":"Lancet"},{"key":"ref_13","first-page":"57","article-title":"Distribution and constrictor effects of substance P in guinea-pig tracheobronchial tissue","author":"Nilsson, G.; Dahlberg, K.; Brodin, E.; Sundler, F.; Strandberg, K.","year":"1977","unstructured":"Nilsson G, Dahlberg K, Brodin E, Sundler F, Strandberg K. Distribution and constrictor effects of substance P in guinea-pig tracheobronchial tissue. In: von Euler US, Pernow B, eds. Substance P. New York: Raven Press, 1977:57-61."},{"key":"ref_14","first-page":"251","article-title":"Sensory substance P-immunoreactive nerves in the lower respiratory tract of various mammals including man","volume":"235","author":"Lundberg, J.M.; Hokfelt, T.; Martling, C.-R.; Saria, A.; Cuello, C.","year":"1984","unstructured":"Lundberg JM, Hokfelt T, Martling C-R, Saria A, Cuello C. Sensory substance P-immunoreactive nerves in the lower respiratory tract of various mammals including man. Cell Tis*e Res 1984;235:251-61.","journal-title":"Cell Tis*e Res"},{"key":"ref_15","first-page":"255","article-title":"Molecular biological studies on the diversity of chemical signalling in tachykinin peptidergic neurons","volume":"579","author":"Krause, J.E.; Hershey, A.D.; Dykema, P.E.; Takeda, Y.","year":"1990","unstructured":"Krause JE, Hershey AD, Dykema PE, Takeda Y. Molecular biological studies on the diversity of chemical signalling in tachykinin peptidergic neurons. Ann N Y Acad Sci 1990;579:255-72.","journal-title":"Ann N Y Acad Sci"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-2999(86)90380-8","article-title":"Autoradiographic mapping of substance P receptors in lung","volume":"127","author":"Carstairs, JR, Barnes; P.J.","year":"1986","unstructured":"Carstairs JR, Barnes PJ. Autoradiographic mapping of substance P receptors in lung. Eur Jf Pharmacol 1986; 127:295-6.","journal-title":"Eur Jf Pharmacol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1152\/jappl.1990.68.4.1679","article-title":"Capsaicin-induced bronchoconstriction and neuropeptide release in guinea-pig perfused lungs","volume":"68","author":"Kroll, F.; Karlsson, J.-A.; Lundberg, J.M.; Persson, C.G.A.","year":"1990","unstructured":"Kroll F, Karlsson J-A, Lundberg JM, Persson CGA. Capsaicin-induced bronchoconstriction and neuropeptide release in guinea-pig perfused lungs. J Appl Physiol 1990;68: 1679-87.","journal-title":"J Appl Physiol"},{"key":"ref_18","first-page":"571","article-title":"Effect of neuropeptides on bronchial blood flow and pulmonary resistance in conscious sheep [abstract]. Thorax 1989; 44: 884P","volume":"134","author":"Nichol, G.M.; Parsons, G.H.; Barnes, P.J.; Chung, K.F.","year":"1988","unstructured":"Nichol GM, Parsons GH, Barnes PJ, Chung KF. Effect of neuropeptides on bronchial blood flow and pulmonary resistance in conscious sheep [abstract]. Thorax 1989; 44:884P. 19 Alving K, Matran R, Lacroix JS, Lundberg JM. Allergen challenge induces vasodilation in pig bronchial circulation via a capsaicin sensitive mechanism. Acta Physiol Scand 1988;134:571-2.","journal-title":"Acta Physiol Scand; Alving"},{"key":"ref_19","first-page":"1262","article-title":"Effects of neuropeptides and capsaicin on the canine tracheal vasculature in vivo","volume":"95","author":"Salonen, R.O.; Webber, S.E.; Widdicombe, J.G.","year":"1988","unstructured":"Salonen RO, Webber SE, Widdicombe JG. Effects of neuropeptides and capsaicin on the canine tracheal vasculature in vivo. BrJPharmacol 1988;95:1262-70.","journal-title":"BrJPharmacol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1748-1716.1987.tb08156.x","article-title":"Nervous control of tracheal blood flow in the cat measured by the laser doppler technique","volume":"130","author":"Marding, C.-R.; Gazelius, B.; Lundberg, J.M.","year":"1987","unstructured":"Marding C-R, Gazelius B, Lundberg JM. Nervous control of tracheal blood flow in the cat measured by the laser doppler technique. Acta Physiol Scand 1987;130: 409-17.","journal-title":"Acta Physiol Scand"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1152\/jappl.1987.63.3.923","article-title":"Possible sensory receptor of nonadrenergic inhibitory nervous system","volume":"63","author":"Ichinose, M.; Inoue, H.; Miura, M.; Yafuso, N.; Nogami, H.; Talishima, T.","year":"1987","unstructured":"Ichinose M, Inoue H, Miura M, Yafuso N, Nogami H, Talishima T. Possible sensory receptor of nonadrenergic inhibitory nervous system. J Appl Physiol 1987;63: 923-9.","journal-title":"J Appl Physiol"},{"key":"ref_22","first-page":"417","article-title":"Bioactive peptides in capsaicin-sensitive C-fiber afferents of the airways: functional and pathophysiological implications","volume-title":"The aiTaysN.eural control in health and disease","author":"Lundberg, J.M.; Saria, A.; Lundblad, L.; Anggird, A.; Martling, C.R.; Theodorson-Norheim, E.","year":"1988","unstructured":"Lundberg JM, Saria A, Lundblad L, Anggird A, Martling CR, Theodorson-Norheim E, et al. Bioactive peptides in capsaicin-sensitive C-fiber afferents of the airways: functional and pathophysiological implications. In: Kaliner MA, Barnes PJ, eds. The aiTaysN.eural control in health and disease. New York: Marcel Dekker, 1988: 417-445."},{"key":"ref_23","first-page":"181","article-title":"Effects of different substance P analogues on tachykinin-induced contraction of airway smooth muscle","author":"Karlsson, J.-A.; Persson, C.G.A.","year":"1985","unstructured":"Karlsson J-A, Persson CGA. Effects of different substance P analogues on tachykinin-induced contraction of airway smooth muscle. In: HAkansson R, Sundler F, eds. Tachykinin antagonists. Amsterdam: Elsevier, 1985: 181-8."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/0024-3205(87)90130-5","article-title":"Occurrence and effects of multiple tachykinins: substance P, neurokinin A and neuropeptide K in human lower airways","volume":"40","author":"Marding, C.-R.; Theodorson-Norheim, E.; Lundberg, J.M.","year":"1987","unstructured":"Marding C-R, Theodorson-Norheim E, Lundberg JM. Occurrence and effects of multiple tachykinins: substance P, neurokinin A and neuropeptide K in human lower airways. Life Sci 1987;40:1633-43.","journal-title":"Life Sci"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1152\/jappl.1987.62.4.1473","article-title":"Bloom SR Effect of substance P on cardiovascular and respiratory function in subjects","volume":"62","author":"Fuller, R.W.; Maxwell, D.L.; Dixon, C.M.S.; McGregor, G.P.; Barnes, P.J.","year":"1987","unstructured":"Fuller RW, Maxwell DL, Dixon CMS, McGregor GP, Barnes PJ, Bloom SR Effect of substance P on cardiovascular and respiratory function in subjects J Appl Physiol 1987;62:1473-9.","journal-title":"J Appl Physiol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0091-6749(89)90080-8","article-title":"The effect of nedocromil sodium on the bronchoconstrictor effect of neurokinin A in subjects with asthma","volume":"83","author":"Joos, G.F.; Pauwels, R.A.; Van Der Straeten, M.E.","year":"1989","unstructured":"Joos GF, Pauwels RA, Van Der Straeten ME. The effect of nedocromil sodium on the bronchoconstrictor effect of neurokinin A in subjects with asthma. J Allergy Clin Immunol 1989;83:663-8.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0952-0600(88)90009-9","article-title":"The effect of oxitropium bromide on neurokinin A-induced bronchoconstriction in asthmatics","volume":"1","author":"Joos, G.F.; Pauwels, R.A.; Van Der Straeten, M.E.","year":"1988","unstructured":"Joos GF, Pauwels RA, Van Der Straeten ME. The effect of oxitropium bromide on neurokinin A-induced bronchoconstriction in asthmatics. Pulmon Pharmacol 1988; 1:41-5.","journal-title":"Pulmon Pharmacol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1152\/jappl.1985.58.4.1080","article-title":"The bronchoconstrictor response to inhaled capsaicin in humans","volume":"85","author":"Fuller, R.W.; Dixon, C.M.S.; Barnes, P.J.","year":"1985","unstructured":"Fuller RW, Dixon CMS, Barnes PJ. The bronchoconstrictor response to inhaled capsaicin in humans. J Appl Physiol 1985;85:1080-4.","journal-title":"J Appl Physiol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1164\/ajrccm\/145.6.1275","article-title":"The effect of an inhaled neutral endopeptidase inhibitor, thiorphan on airway responses to neurokinin A in normal humans in vivo","volume":"145","author":"Cheung, D.; Bel, E.H.; Den Hartigh, J.; Dijkman, J.H.; Sterk, P.J.","year":"1992","unstructured":"Cheung D, Bel EH, Den Hartigh J, Dijkman JH, Sterk PJ. The effect of an inhaled neutral endopeptidase inhibitor, thiorphan on airway responses to neurokinin A in normal humans in vivo. Am Rev Respir Dis 1992; 145:1275-80.","journal-title":"Am Rev Respir Dis"},{"key":"ref_30","first-page":"682","article-title":"An inhaled neutral endopeptidase inhibitor, thiorphan, enhances airway narrowing to neurokinin A in asthmatic subjects in vivo","volume":"145","author":"Cheung, D.; Timmers, M.C.; Bel, E.H.; Den Hartigh, J.; Dijkman, J.H.; Sterk, P.J.","year":"1992","unstructured":"Cheung D, Timmers MC, Bel EH, Den Hartigh J, Dijkman JH, Sterk PJ. An inhaled neutral endopeptidase inhibitor, thiorphan, enhances airway narrowing to neurokinin A in asthmatic subjects in vivo [abstract]. Am Rev Respir Dis 1992;145:A682.","journal-title":"Am Rev Respir Dis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF00314856","article-title":"Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects","volume":"42","author":"Nichol, G.M.; O'Connor, B.J.; Lecomte, J.M.; Chung, K.F.; Barnes, P.J.","year":"1992","unstructured":"Nichol GM, O'Connor BJ, Lecomte JM, Chung KF, Barnes PJ. Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects. Eur J Clin Pharmacol 1992;42: 491-4.","journal-title":"Eur J Clin Pharmacol"},{"key":"ref_32","first-page":"10208","article-title":"et al Pharmacological properties of a potent and selective nonpeptide","volume-title":"substance P antagonist. Proc Natl Acad Sci (USA)","volume":"88","author":"Garret, C.; Carruette, A.; Fardin, V.; Moussaoui, S.; Peyronel, J.-F.; Blanchard, J.-C.","year":"1991","unstructured":"Garret C, Carruette A, Fardin V, Moussaoui S, Peyronel J-F, Blanchard J-C, et al Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc Natl Acad Sci (USA) 1991;88:10208-12."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1126\/science.1703323","article-title":"et al A potent non-peptide antagonist of the substance P (NKJ) receptor","volume":"251","author":"Snider, R.M.; Constantine, J.W.; m JA, Lowe; Longo, K.P.; Lebel, W.S.; Woody, H.A.","year":"1991","unstructured":"Snider RM, Constantine JW, Lowe m JA, Longo KP, Lebel WS, Woody HA, et al A potent non-peptide antagonist of the substance P (NKJ) receptor. Science 1991;251:435-7.","journal-title":"Science"},{"key":"ref_34","first-page":"356","article-title":"Nasal response to substance P and methacholine in subjects with and without allergic rhinitis","volume":"1","author":"Devillier, P.; Dessanges, J.F.; Rakotoshanaka, F.; Ghaem, A.; Boushey, H.A.; Lockhart, A.","year":"1988","unstructured":"Devillier P, Dessanges JF, Rakotoshanaka F, Ghaem A, Boushey HA, Lockhart A, et al. Nasal response to substance P and methacholine in subjects with and without allergic rhinitis. EurRespirl 1988;1:356-61.","journal-title":"EurRespirl"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1476-5381.1988.tb10305.x","article-title":"Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man","volume":"93","author":"Geppetti, P.; Fusco, B.M.; Mararini, S.; Maggi, C.A.; Fanciullacci, M.; Sicuteri, F.","year":"1988","unstructured":"Geppetti P, Fusco BM, Mararini S, Maggi CA, Fanciullacci M, Sicuteri F. Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man. BrJ Pharmacol 1988;93:509-14.","journal-title":"BrJ Pharmacol"},{"key":"ref_36","first-page":"255","article-title":"Substance P and human nasal mucociliary activity","volume":"30","author":"Karlsson, G.; Pipkorn, U.; Andreasson, L.","year":"1986","unstructured":"Karlsson G, Pipkorn U, Andreasson L. Substance P and human nasal mucociliary activity. Eur J Clin Pharmacol 1986;30:255-7.","journal-title":"Eur J Clin Pharmacol"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1476-5381.1989.tb11870.x","article-title":"Capsaicin and nicotine-sensitive afferent neurones and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis","volume":"96","author":"Stjarne, P.; Lundblad, L.; Lundberg, J.M.; Anggard, A.","year":"1989","unstructured":"Stjarne P, Lundblad L, Lundberg JM, Anggard A. Capsaicin and nicotine-sensitive afferent neurones and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis. Br Jf Pharmacol 1989; 96:693-701.","journal-title":"Br Jf Pharmacol"},{"key":"ref_38","first-page":"87","article-title":"Larsson 0, Lundberg JsaMi, cinSairnidauAc.edAourtaolnsoemnisactimoencshaanndissmaslivuantdieonrliyninmganc.apJPhysiol","volume":"373","author":"Duner-Engstrom, M.; Fredholm, B.B.","year":"1986","unstructured":"Duner-Engstrom M, Fredholm BB, Larsson 0, Lundberg JsaMi,cinSairnidauAc.edAourtaolnsoemnisactimoencshaanndissmaslivuantdieonrliyninmganc.apJPhysiol 1986;373:87-96."},{"key":"ref_39","first-page":"1323","article-title":"Effect of intranasal capsaicin on symptoms and mediator release. J'","volume":"259","author":"Bascom, R.; Kagey-Sobotka, A.; Proud, D.","year":"1991","unstructured":"Bascom R, Kagey-Sobotka A, Proud D. Effect of intranasal capsaicin on symptoms and mediator release. J' Pharmacol Exp Ther 1991;259:1323-7.","journal-title":"Pharmacol Exp Ther"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1398-9995.1987.tb02182.x","article-title":"Capsaicin-sensitive nerves and the cutaneous allergy reaction in man","volume":"42","year":"1987","unstructured":"Lundblad L, Lundberg JM, Anggard A, Zetterstrom 0. Capsaicin-sensitive nerves and the cutaneous allergy reaction in man. Allergy 1987;42:20-5.","journal-title":"Allergy"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1476-5381.1986.tb16246.x","article-title":"Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex","volume":"88","author":"Barnes, P.J.; Brown, M.J.; Dollery, C.T.; Fuller, R.W.; Heavey, D.J.; Ind, P.W.","year":"1986","unstructured":"Barnes PJ, Brown MJ, Dollery CT, Fuller RW, Heavey DJ, Ind PW. Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex. BrJ Pharmacol 1986;88:741-5.","journal-title":"BrJ Pharmacol"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0952-0600(88)90008-7","article-title":"Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in guinea pigs","volume":"1","author":"Forsberg, K.; Karlsson, J.-A.; Theodorsson, E.; Lundberg, J.M.; Persson, C.G.A.","year":"1988","unstructured":"Forsberg K, Karlsson J-A, Theodorsson E, Lundberg JM, Persson CGA. Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in guinea pigs. Pulmon Pharmacol 1988;1:33-9.","journal-title":"Pulmon Pharmacol"},{"issue":"158","key":"ref_43","article-title":"Inhibitors of ACE and enkephalinase potentiate irritant induced bronchoconstriction, but not cough, in conscious guinea pigs","volume":"96","author":"Karlsson, J.-A.; Zackrisson, C.; Forsberg, K.","year":"1988","unstructured":"Karlsson J-A, Zackrisson C, Forsberg K. Inhibitors of ACE and enkephalinase potentiate irritant induced bronchoconstriction, but not cough, in conscious guinea pigs [abstract]. BrJ Pharnacol 1988;96: 158P. 46 Hansson L, Wollmer P, Dahlback M, Karlsson J-A.","journal-title":"BrJ Pharnacol; Karlsson J-A"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1748-1716.1991.tb09105.x","article-title":"Hyper-responsiveness to tussive stimuli in cigarette smoke-exposed guinea-pigs: a role for capsaicin-sensitive, calcitonin gene related peptide-containing nerves","volume":"141","author":"Karlsson, J.-A.; Zackrisson, C.; Lundberg, J.M.","year":"1991","unstructured":"Karlsson J-A, Zackrisson C, Lundberg JM. Hyper-responsiveness to tussive stimuli in cigarette smoke-exposed guinea-pigs: a role for capsaicin-sensitive, calcitonin gene related peptide-containing nerves. Acta Physiol Scand 1991;141:445-54.","journal-title":"Acta Physiol Scand"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/0024-3205(83)90060-7","article-title":"Effects of capsaicin in inflammation and on the substance P content of nervous tissue in rats with adjuvant arthritis","volume":"32","author":"Colpaert, F.C.; Donnerer, J.; Lembeck, F.","year":"1983","unstructured":"Colpaert FC, Donnerer J, Lembeck F. Effects of capsaicin in inflammation and on the substance P content of nervous tissue in rats with adjuvant arthritis. Life Sci 1983; 32:1827-34.","journal-title":"Life Sci"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3940(89)90382-0","article-title":"Enhancement of preprotachykinin A gene expression by adjuvant-induced inflammation in the rat spinal cord: possible involvement of substance P-containing spinal neurons in nociception","volume":"98","author":"Minami, M.; Kuraishi, Y.; Kawamura, M.; Yamaguchi, T.; Masu, Y.; Nakanishi, S.","year":"1989","unstructured":"Minami M, Kuraishi Y, Kawamura M, Yamaguchi T, Masu Y, Nakanishi S, et al. Enhancement of preprotachykinin A gene expression by adjuvant-induced inflammation in the rat spinal cord: possible involvement of substance P-containing spinal neurons in nociception. Neurosci Len 1989;98:105-10.","journal-title":"Neurosci Len"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0306-4522(88)90064-4","article-title":"Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, Karlsson calcitonin gene related peptide and other neuropeptides","volume":"24","author":"Holzer, P.","year":"1988","unstructured":"Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, Karlsson calcitonin gene related peptide and other neuropeptides. Neuroscience 1988;24:739-68.","journal-title":"Neuroscience"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1523\/JNEUROSCI.06-12-03423.1986","article-title":"Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis","volume":"6","author":"Levine, J.D.; Dardick, S.J.; Roizan, M.F.; Helms, C.; Basbaum, A.I.","year":"1986","unstructured":"Levine JD, Dardick SJ, Roizan MF, Helms C, Basbaum AI. Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis. Neurosci 1986;6:3423-9.","journal-title":"Neurosci"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1136\/bmj.295.6605.1025-a","article-title":"Increased cough reflex associated with angiotensin converting enzyme inhibitor cough","volume":"295","author":"Fuller, R.W.; Choudry, N.B.","year":"1987","unstructured":"Fuller RW, Choudry NB. Increased cough reflex associated with angiotensin converting enzyme inhibitor cough. BMJ 1987;295:1025-6.","journal-title":"BMJ"},{"key":"ref_50","first-page":"256","article-title":"Cough elicited by capsaicin in normal subjects and patients with chronic cough [abstract]. Bull Eur Physiopathol Respir 1987; 23(suppl 12): 410S. 54 Fuller RW, Choudry NB. Patients with a non-productive cough have an increased cough reflex","volume":"43","author":"Hanson, L.Midgren B.; BG, Simonsson","year":"1988","unstructured":"Hanson, L. Midgren B, Simonsson BG. Cough elicited by capsaicin in normal subjects and patients with chronic cough [abstract]. Bull Eur Physiopathol Respir 1987; 23(suppl 12):410S. 54 Fuller RW, Choudry NB. Patients with a non-productive cough have an increased cough reflex [abstract]. Thorax 1988;43:256."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1183\/09031936.93.05030296","article-title":"Sensitivity of the cough reflex in patients with chronic cough","volume":"5","author":"Choudry, N.B.; Fuller, R.W.","year":"1992","unstructured":"Choudry NB, Fuller RW. Sensitivity of the cough reflex in patients with chronic cough. Eur Respir 1992;5: 296-300.","journal-title":"Eur Respir"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1055\/s-2007-998536","article-title":"Neue Aspekte zur Pathogenese und Therapie der hyperflektorischen Rhinopathie","volume":"67","author":"Saria, A.; Wolfe, G.","year":"1988","unstructured":"Saria A, Wolfe G. Neue Aspekte zur Pathogenese und Therapie der hyperflektorischen Rhinopathie. Laryngorhinootologie 1988;67:438-45.","journal-title":"Laryngorhinootologie"},{"key":"ref_53","first-page":"595","article-title":"Improvement of symptoms of non-allerigc chronic rhinitis by local treatment with capsaicin. Clin Exp Allergy","volume":"21","author":"Lacroix, J.L.; Buvelot, J.M.; Polla, B.S.; Lundberg, J.M.","year":"1991","unstructured":"Lacroix JL, Buvelot JM, Polla BS, Lundberg JM. Improvement of symptoms of non-allerigc chronic rhinitis by local treatment with capsaicin. Clin Exp Allergy 1991;21:595-600."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0007-0971(77)90073-0","article-title":"Lignocaine aerosol and persistent cough","volume":"71","author":"Howard, P.; Cayton, R.M.; Brennan, SR, Anderson; P.B.","year":"1977","unstructured":"Howard P, Cayton RM, Brennan SR, Anderson PB. Lignocaine aerosol and persistent cough. Br Dis Chest 1977;71: 19-24.","journal-title":"Br Dis Chest"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1001\/jama.1984.03350170058022","article-title":"Prolonged suppression of cough after inhalation of lidocaine in a patient with sarcoidosis","volume":"252","author":"Sanders, R.V.; Kirkpatrick, M.B.","year":"1984","unstructured":"Sanders RV, Kirkpatrick MB. Prolonged suppression of cough after inhalation of lidocaine in a patient with sarcoidosis. JAMA 1984;252:2456-7.","journal-title":"JAMA"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.48.4.396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T22:36:14Z","timestamp":1684794974000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.48.4.396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4,1]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/thx.48.4.396","relation":{},"ISSN":["0040-6376"],"issn-type":[{"value":"0040-6376","type":"print"}],"subject":[],"published":{"date-parts":[[1993,4,1]]}}}