{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:33:46Z","timestamp":1760132026310},"reference-count":29,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1994,4,1]]},"DOI":"10.1136\/thx.49.4.307","type":"journal-article","created":{"date-parts":[[2008,12,13]],"date-time":"2008-12-13T03:22:59Z","timestamp":1229138579000},"page":"307-311","source":"Crossref","is-referenced-by-count":10,"title":["Inhibition of sodium metabisulphite induced bronchoconstriction by frusemide in asthma: role of cyclooxygenase products."],"prefix":"10.1136","volume":"49","author":[{"given":"B J","family":"O'Connor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K F","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/ajrccm\/142.3.576","article-title":"Effect of inhaled frusemide on metabisulphiteand methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects","volume":"142","author":"Nichol, G.M.; Alton, E.W.; Nix, A.; Geddes, D.M.; Chung, K.F.; Barnes, P.J.","year":"1990","unstructured":"Nichol GM, Alton EW, Nix A, Geddes DM, Chung KF, Barnes PJ. Effect of inhaled frusemide on metabisulphiteand methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis 1990;142:576-80.","journal-title":"Am Rev Respir Dis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1164\/ajrccm\/143.6.1329","article-title":"Effect of inhaled frusemide and bumetanide on adenosine 5'-monophosphateand sodium metabisulphite-induced bronchoconstriction in asthmatic subjects","volume":"143","author":"O'Connor, B.J.; Chung, K.F.; Chen-Wordsdell, Y.M.; Fuller, R.W.; Barnes, P.J.","year":"1991","unstructured":"O'Connor BJ, Chung KF, Chen-Wordsdell YM, Fuller RW, Barnes PJ. Effect of inhaled frusemide and bumetanide on adenosine 5'-monophosphateand sodium metabisulphite-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis 1991;143:1329-33.","journal-title":"Am Rev Respir Dis"},{"key":"ref_3","first-page":"252","article-title":"Prevention of exercise-induced bronchoconstriction by inhaled frusemide","volume":"ii:","author":"Bianco, S.; Vaghi, A.; Robuschi, M.; Pasargiklian, M.","year":"1988","unstructured":"Bianco S, Vaghi A, Robuschi M, Pasargiklian M. Prevention of exercise-induced bronchoconstriction by inhaled frusemide. Lancet 1988;ii:252-5.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1056\/NEJM198910193211602","article-title":"Protective effect of inhaled frusemide on allergen-induced early and late asthmatic reactions","volume":"321","author":"Bianco, S.; Pieroni, M.G.; Refini, R.M.; Rottoli, L.; Sestini, P.","year":"1989","unstructured":"Bianco S, Pieroni MG, Refini RM, Rottoli L, Sestini P. Protective effect of inhaled frusemide on allergen-induced early and late asthmatic reactions. N Engl J Med 1989;321:1069-73.","journal-title":"N Engl J Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0952-0600(89)80016-X","article-title":"Inhaled frusemide is highly effective in preventing ultrasonically nebulised water bronchoconstriction","volume":"1","author":"Robuschi, M.; Gamboro, G.; Spagnotto, S.; Vaghi, A.; Bianco, S.","year":"1989","unstructured":"Robuschi M, Gamboro G, Spagnotto S, Vaghi A, Bianco S. Inhaled frusemide is highly effective in preventing ultrasonically nebulised water bronchoconstriction. Pulmon Pharmacol 1989;1:187-91.","journal-title":"Pulmon Pharmacol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2125.1984.tb02383.x","article-title":"Contribution of prostaglandins to the systemic and renal vascular response to frusemide in normal man","volume":"17","author":"Mackay, I.G.; Muir, A.L.; Watson, M.L.","year":"1984","unstructured":"Mackay IG, Muir AL, Watson ML. Contribution of prostaglandins to the systemic and renal vascular response to frusemide in normal man. Br J Clin Pharmacol 1984;17:513-9.","journal-title":"Br J Clin Pharmacol"},{"key":"ref_7","first-page":"555","article-title":"Mechanism of frusemide-induced natriuresis by direct stimulation of renal prostaglandin E2","volume":"247","author":"Katayama, S.; Attallah, A.A.; Stahl, R.A.; Bloch, D.L.; Lee, J.B.","year":"1984","unstructured":"Katayama S, Attallah AA, Stahl RA, Bloch DL, Lee JB. Mechanism of frusemide-induced natriuresis by direct stimulation of renal prostaglandin E2. Am J Physiol 1984;247:F555-F561.","journal-title":"Am J Physiol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1165\/ajrcmb\/1.3.245","article-title":"Release of 15-hydroxyeicosatetraenoic acid (15-HETE) and prostaglandin E2 by cultivated human bronchial epithelial cells","volume":"1","author":"Salari, H.; Chan Yeung, M.","year":"1989","unstructured":"Salari H, Chan Yeung M. Release of 15-hydroxyeicosatetraenoic acid (15-HETE) and prostaglandin E2 by cultivated human bronchial epithelial cells. Am J Respir Cell Mol Biol 1989;1:245-50.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/thx.46.9.633","article-title":"Effect of inhaled prostaglandin E2 on bronchial reactivity to sodium metabisulphite and methacholine in subjects with asthma","volume":"46","author":"Pavord, I.; Wisniewski, A.; Mathur, R.; Wahedna, I.; Knox, A.; Tattersfield, A.","year":"1991","unstructured":"Pavord I, Wisniewski A, Mathur R, Wahedna I, Knox A, Tattersfield A. Effect of inhaled prostaglandin E2 on bronchial reactivity to sodium metabisulphite and methacholine in subjects with asthma. Thorax 1991;46:633-7.","journal-title":"Thorax"},{"key":"ref_10","first-page":"461","article-title":"Clinical, functional and pathogenetic aspects of bronchial reactivity to prostaglandins F2, El, and E2. Adv Prostaglandin Thromboxane Leukotrienc Res","volume":"1","author":"Pasargiklian, M.; Bianco, S.; Allegra, L.","year":"1976","unstructured":"Pasargiklian M, Bianco S, Allegra L. Clinical, functional and pathogenetic aspects of bronchial reactivity to prostaglandins F2, El, and E2. Adv Prostaglandin Thromboxane Leukotrienc Res 1976;1:461-75."},{"key":"ref_11","first-page":"78","article-title":"Aspects of bronchial reactivity to prostaglandins and aspirin in asthmatic patients","volume":"34","author":"Pasargiklian, M.; Bianco, S.; Allegra, L.; Moauero, N.E.; Petrigni, G.; Robuschi, M.","year":"1977","unstructured":"Pasargiklian M, Bianco S, Allegra L, Moauero NE, Petrigni G, Robuschi M, et al. Aspects of bronchial reactivity to prostaglandins and aspirin in asthmatic patients. Respiration 1977;34:78-91.","journal-title":"Respiration"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1136\/thx.44.12.1009","article-title":"Characterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma","volume":"44","author":"Nichol, G.M.; Nix, A.; Chung, K.F.; Barnes, P.J.","year":"1989","unstructured":"Nichol GM, Nix A, Chung KF, Barnes PJ. Characterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma. Thorax 1989;44:1009-14.","journal-title":"Thorax"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1164\/ajrccm\/141.6.1400","article-title":"Effect of inhaled preservatives on asthmatic subjects","volume":"141","author":"Wright, W.; Zhang, Y.G.; Salome, C.M.; Woolcock, A.J.","year":"1990","unstructured":"Wright W, Zhang YG, Salome CM, Woolcock AJ. Effect of inhaled preservatives on asthmatic subjects. I. Sodium metabisulphite. Am Rev Respir Dis 1990;141:1400-4.","journal-title":"I. Sodium metabisulphite. Am Rev Respir Dis"},{"key":"ref_14","first-page":"238","article-title":"Metabisulphite-induced bronchoconstriction: mechanisms","volume":"137","author":"Dixon, C.M.S.; Ind, P.W.","year":"1988","unstructured":"Dixon CMS, Ind PW. Metabisulphite-induced bronchoconstriction: mechanisms. Am Rev Respir Dis 1988;137:A238.","journal-title":"Am Rev Respir Dis"},{"key":"ref_15","first-page":"371","article-title":"Inhaled sodium metabisulphiteinduced bronchoconstriction: inhibition by nedocromil sodium and sodium cromoglycate. Br J7 Clin","volume":"30","author":"Dixon, C.M.S.; Ind, P.W.","year":"1990","unstructured":"Dixon CMS, Ind PW. Inhaled sodium metabisulphiteinduced bronchoconstriction: inhibition by nedocromil sodium and sodium cromoglycate. Br J7 Clin Pharmacol 1990;30:371-6.","journal-title":"Pharmacol"},{"key":"ref_16","first-page":"548","article-title":"Effect of inhaled lysine acetylsalicylic acid and frusemide on exercise-induced asthma","volume":"143","author":"Wilkens, J.H.; Wilkens, H.; Nieger, M.; Duft, S.; Frolich, J.C.; Fabel, H.","year":"1991","unstructured":"Wilkens JH, Wilkens H, Nieger M, Duft S, Frolich JC, Fabel H, et al. Effect of inhaled lysine acetylsalicylic acid and frusemide on exercise-induced asthma. Am Rev Respir Dis 1991;143:A548.","journal-title":"Am Rev Respir Dis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1136\/thx.47.10.797","article-title":"Inhaled frusemide and exercise-induced asthma. Evidence of a role for inhibitory prostanoids","volume":"47","author":"Pavord, I.D.; Wisniewski, A.; Tattersfield, A.E.","year":"1992","unstructured":"Pavord ID, Wisniewski A, Tattersfield AE. Inhaled frusemide and exercise-induced asthma. Evidence of a role for inhibitory prostanoids. Thorax 1992;47:797-800.","journal-title":"Thorax"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/thx.42.12.946","article-title":"Effects of a cyclooxygenase inhibitor, flurbiprofen, and an H, histamine receptor antagonist, terfenadine, alone and in combination on allergen-induced immediate bronchoconstriction in man","volume":"42","author":"Curzen, N.; Rafferty, P.; Holgate, S.T.","year":"1987","unstructured":"Curzen N, Rafferty P, Holgate ST. Effects of a cyclooxygenase inhibitor, flurbiprofen, and an H, histamine receptor antagonist, terfenadine, alone and in combination on allergen-induced immediate bronchoconstriction in man. Thorax 1987;42:946-52.","journal-title":"Thorax"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1183\/09031936.93.03050540","article-title":"Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination","volume":"3","author":"Finnerty, J.P.; Holgate, S.T.","year":"1990","unstructured":"Finnerty JP, Holgate ST. Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination. Eur Respir J 1990;3:540-7.","journal-title":"Eur Respir J"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1164\/ajrccm\/139.2.463","article-title":"The effect of oral terfenadine alone and in combination with flurbiprofen on the bronchoconstrictor response to inhaled adenosine 5'-monophosphate in non-atopic asthma","volume":"139","author":"Phillips, G.D.; Holgate, S.T.","year":"1989","unstructured":"Phillips GD, Holgate ST. The effect of oral terfenadine alone and in combination with flurbiprofen on the bronchoconstrictor response to inhaled adenosine 5'-monophosphate in non-atopic asthma. Am Rev Respir Dis 1989;139:463-9.","journal-title":"Am Rev Respir Dis"},{"key":"ref_21","first-page":"609","article-title":"Indomethacin modification of immediate-type immunologic airway responses in allergic asthmatic and non-asthmatic subjects: evidence for altered arachidonic acid metabolism in asthma","volume":"123","author":"Fish, J.E.; Ankin, M.G.; Adkinson, N.F.J.; Peterman, VI","year":"1981","unstructured":"Fish JE, Ankin MG, Adkinson NFJ, Peterman VI. Indomethacin modification of immediate-type immunologic airway responses in allergic asthmatic and non-asthmatic subjects: evidence for altered arachidonic acid metabolism in asthma. Am Rev Respir Dis 1981;123:609-14.","journal-title":"Am Rev Respir Dis"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0952-0600(90)90004-3","article-title":"Adenosine-induced bronchoconstriction in human asthmatics: effects of pretreatment with indomethacin or atropine sulfate","volume":"3","author":"Kung, M.; Diamond, L.","year":"1990","unstructured":"Kung M, Diamond L. Adenosine-induced bronchoconstriction in human asthmatics: effects of pretreatment with indomethacin or atropine sulfate. Pulmon Pharmacol 1990;3: 17-23.","journal-title":"Pulmon Pharmacol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1042\/cs0560077","article-title":"Time-dependent change in prostaglandin excretion in response to frusemide in man","volume":"56","author":"Scherer, B.; Weber, P.C.","year":"1979","unstructured":"Scherer B, Weber PC. Time-dependent change in prostaglandin excretion in response to frusemide in man. Clin Sci 1979;56:77-81.","journal-title":"Clin Sci"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2125.1985.tb05077.x","article-title":"Characteristics of prostaglandin-induced cough in man","volume":"20","author":"Costello, J.F.; Dunlop, L.S.; Gardiner, P.J.","year":"1985","unstructured":"Costello JF, Dunlop LS, Gardiner PJ. Characteristics of prostaglandin-induced cough in man. Br J Clin Pharmacol 1985;20:355-9.","journal-title":"Br J Clin Pharmacol"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1164\/ajrccm\/142.1.143","article-title":"Inhaled frusemide inhibits cough-induced by low chloride content solutions but not by capsaicin","volume":"142","author":"Ventresca, P.G.; Nichol, G.M.; Barnes, P.J.; Chung, K.F.","year":"1990","unstructured":"Ventresca PG, Nichol GM, Barnes PJ, Chung KF. Inhaled frusemide inhibits cough-induced by low chloride content solutions but not by capsaicin. Am Rev Respir Dis 1990;142: 143-6.","journal-title":"Am Rev Respir Dis"},{"key":"ref_26","first-page":"548","article-title":"Frusemide inhibits cough but not bronchoconstriction to prostaglandin F2 alpha in patients with asthma","volume":"143","author":"Stone, R.A.; Yeo, C.T.; Barnes, P.J.; Chung, K.F.","year":"1991","unstructured":"Stone RA, Yeo CT, Barnes PJ, Chung KF. Frusemide inhibits cough but not bronchoconstriction to prostaglandin F2 alpha in patients with asthma. Am Rev Respir Dis 1991;143:A548.","journal-title":"Am Rev Respir Dis"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1113\/jphysiol.1983.sp014770","article-title":"Rapid shallow breathing evoked by selective stimulation of airway C fibers in dogs","volume":"340","author":"Coleridge, H.M.; Coleridge, J.C.; Roberts, A.M.","year":"1983","unstructured":"Coleridge HM, Coleridge JC, Roberts AM. Rapid shallow breathing evoked by selective stimulation of airway C fibers in dogs. J Physiol, Lond 1983;340:415-33.","journal-title":"J Physiol, Lond"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1152\/jappl.1984.57.1.129","article-title":"Control of neurotransmission by prostaglandins in canine trachealis smooth muscle","volume":"57","author":"Walters, E.H.; O'Byrne, P.M.; Fabbri, L.M.; Graf, P.D.; Holtzman, M.J.; Nadel, J.A.","year":"1984","unstructured":"Walters EH, O'Byrne PM, Fabbri LM, Graf PD, Holtzman MJ, Nadel JA. Control of neurotransmission by prostaglandins in canine trachealis smooth muscle. Jf Appl Physiol 1984;57:129-34.","journal-title":"Jf Appl Physiol"},{"key":"ref_29","first-page":"862","article-title":"Frusemide and coughinduced by low [Cl] solution: duration of action","volume":"6","author":"Stone, R.A.; Barnes, P.J.; Chung, K.F.","year":"1993","unstructured":"Stone RA, Barnes PJ, Chung KF. Frusemide and coughinduced by low [Cl] solution: duration of action. Eur J Respir Dis 1993;6:862-7.","journal-title":"Eur J Respir Dis"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.49.4.307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T22:34:29Z","timestamp":1684794869000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.49.4.307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,1]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/thx.49.4.307","relation":{},"ISSN":["0040-6376"],"issn-type":[{"value":"0040-6376","type":"print"}],"subject":[],"published":{"date-parts":[[1994,4,1]]}}}