{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:05:08Z","timestamp":1790384708263,"version":"4.1.0"},"reference-count":48,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1995,7,1]]},"DOI":"10.1136\/thx.50.7.797","type":"journal-article","created":{"date-parts":[[2008,12,13]],"date-time":"2008-12-13T03:22:59Z","timestamp":1229138579000},"page":"797-804","source":"Crossref","is-referenced-by-count":129,"title":["Sleep-related breathing disorder.2. Pathophysiology of obstructive sleep apnoea."],"prefix":"10.1136","volume":"50","author":[{"given":"D P","family":"White","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1152\/jappl.1978.44.6.931","article-title":"Pathogenesis of upper airway occlusion during sleep","volume":"44","author":"Remmers, J.E.; DeGroot, W.J.; Sauerland, E.K.; Anch, A.M.","year":"1978","unstructured":"Remmers JE, DeGroot WJ, Sauerland EK, Anch AM. Pathogenesis of upper airway occlusion during sleep. _7 Appl Physiol 1978;44:931-8","journal-title":"_7 Appl Physiol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1378\/chest.95.6.1202","article-title":"Predictors of objective daytime sleepiness in patients with sleep related breathing disorders","volume":"95","author":"Roehrs, T.; Zorick, F.; Wittig, R.; Conway, W.; Roth, T.","year":"1989","unstructured":"Roehrs T, Zorick F, Wittig R, Conway W, Roth T. Predictors of objective daytime sleepiness in patients with sleep related breathing disorders. Chest 1989;95:1202-6.","journal-title":"Chest"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF01732637","article-title":"Sleep apnea and pulmonary hypertension","volume":"64","author":"Podszus, T.; Bauer, W.; Mayer, J.; Panzel, T.; Peter, J.H.; VonWichert, P.","year":"1986","unstructured":"Podszus T, Bauer W, Mayer J, Panzel T, Peter JH, VonWichert P. Sleep apnea and pulmonary hypertension. Klin Wochenschr 1986;64:131-4.","journal-title":"Klin Wochenschr"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.7326\/0003-4819-103-2-190","article-title":"Undiagnosed sleep apnea in patients with essential hypertension","volume":"103","author":"Fletcher, E.C.; DeBehnker, R.D.; Lovio, M.S.; Goim, A.B.","year":"1985","unstructured":"Fletcher EC, DeBehnker RD, Lovio MS, Goim AB. Undiagnosed sleep apnea in patients with essential hypertension. Ann Intern Med 1985;103:190-5.","journal-title":"Ann Intern Med"},{"key":"ref_5","first-page":"335","article-title":"Relationship of ventricular ectopy to oxyhemoglobin desaturation in patients with obstructive sleep apnea","volume":"83","author":"Shepard, J.W.; Garrison, M.W.; Grither, D.A.; Dolan, G.F.","year":"1985","unstructured":"Shepard JW, Garrison MW, Grither DA, Dolan GF. Relationship of ventricular ectopy to oxyhemoglobin desaturation in patients with obstructive sleep apnea. Chest 1985;83:335-40.","journal-title":"Chest"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1378\/chest.94.1.9","article-title":"Mortality and apnea index in obstructive sleep apnea","volume":"94","author":"He, J.; Kryger, M.H.; Zorick, F.J.; Conway, W.; Roth, T.","year":"1988","unstructured":"He J, Kryger MH, Zorick FJ, Conway W, Roth T. Mortality and apnea index in obstructive sleep apnea. Chest 1988; 94:9-14.","journal-title":"Chest"},{"key":"ref_7","first-page":"807","article-title":"Arousal: the forgotten response to respiratory stimuli","volume":"118","author":"Phillipson, E.A.; Sullivan, C.E.","year":"1978","unstructured":"Phillipson EA, Sullivan CE. Arousal: the forgotten response to respiratory stimuli. Am Rev RespirDis 1978;118:807-9.","journal-title":"Am Rev RespirDis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1152\/jappl.1986.61.4.1403","article-title":"Variable site of airway narrowing among obstructive sleep apnea patients","volume":"61","author":"Hudgel, D.W.","year":"1986","unstructured":"Hudgel DW. Variable site of airway narrowing among obstructive sleep apnea patients. _7 Appl Physiol 1986;61: 1403.","journal-title":"_7 Appl Physiol"},{"issue":"1051","key":"ref_9","first-page":"5","article-title":"Paradoxical glottic narrowing in patients with severe obstructive sleep apnea","volume":"81","author":"Rubinstein, I.; Slutsky, A.S.; Zamel, N.; Hoffstein, V.","year":"1988","unstructured":"Rubinstein I, Slutsky AS, Zamel N, Hoffstein V. Paradoxical glottic narrowing in patients with severe obstructive sleep apnea. Clin Invest 1988;81:1051 -5.","journal-title":"Clin Invest"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0272-5231(21)00414-7","article-title":"The muscles of the upper airways","volume":"7","author":"E, Von Lunteran; KP, Strohl","year":"1986","unstructured":"Von Lunteran E, Strohl KP. The muscles of the upper airways. Clin Chest Med 1986;7:171.","journal-title":"Clin Chest Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1152\/jappl.1987.62.6.2201","article-title":"Effect of hypoxiainduced periodic breathing on upper airway obstruction during sleep","volume":"62","author":"Warner, G.; Skaturd, J.B.; Dempsey, J.A.","year":"1987","unstructured":"Warner G, Skaturd JB, Dempsey JA. Effect of hypoxiainduced periodic breathing on upper airway obstruction during sleep. Appl Physiol 1987;62:2201-11.","journal-title":"Appl Physiol"},{"key":"ref_12","first-page":"1571","article-title":"Waking genioglossal EMG in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism)","volume":"89","author":"Mezzanotte, W.S.; Tangel, D.J.; White, D.P.","year":"1992","unstructured":"Mezzanotte WS, Tangel DJ, White DP. Waking genioglossal EMG in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). _7 Clin Invest 1992;89:1571-9."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/jappl.1985.58.2.365","article-title":"Pharyngeal resistance in normal humans: influence of gender, age and obesity","volume":"58","author":"White, D.P.; Lombard, R.M.; Cadieux, R.J.; Zwillich, C.W.","year":"1985","unstructured":"White DP, Lombard RM, Cadieux RJ, Zwillich CW. Pharyngeal resistance in normal humans: influence of gender, age and obesity. Appl Physiol 1985;58:365-71.","journal-title":"Appl Physiol"},{"key":"ref_14","first-page":"890","article-title":"Pharyngeal cross-sectional area in normal men and women..7Appl Physiol","volume":"61","author":"Brown, I.G.; Zamel, N.; Hoffstein, V.","year":"1986","unstructured":"Brown IG, Zamel N, Hoffstein V. Pharyngeal cross-sectional area in normal men and women..7Appl Physiol 1986;61: 890-5."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1152\/jappl.1990.69.4.1262","article-title":"Geniohyoid muscle activity in normal man during wakefulness and sleep","volume":"69","author":"Wiegand, D.A.; Latz, B.; Zwillich, C.W.; Wiegand, L.","year":"1990","unstructured":"Wiegand DA, Latz B, Zwillich CW, Wiegand L. Geniohyoid muscle activity in normal man during wakefulness and sleep. Appl Physiol 1990;69:1262-9.","journal-title":"Appl Physiol"},{"key":"ref_16","first-page":"1053","article-title":"The influence of sleep on the activity of tonic postural versus inspiratory phasic muscles in normal men","volume":"73","author":"Tangel, D.J.; Mezzanotte, W.S.; Sandberg, E.J.; White, D.P.","year":"1992","unstructured":"Tangel DJ, Mezzanotte WS, Sandberg EJ, White DP. The influence of sleep on the activity of tonic postural versus inspiratory phasic muscles in normal men. Appl Physiol 1992;73:1053-66.","journal-title":"Appl Physiol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1152\/jappl.1991.70.6.2574","article-title":"The influence of sleep on tensor palatini EMG and upper airway resistance in normal subjects","volume":"70","author":"Tangel, D.T.; Mezzanotte, W.S.; White, D.P.","year":"1991","unstructured":"Tangel DT, Mezzanotte WS, White DP. The influence of sleep on tensor palatini EMG and upper airway resistance in normal subjects. _7Appl Physiol 1991;70:2574-81.","journal-title":"_7Appl Physiol"},{"issue":"124","key":"ref_18","first-page":"215","article-title":"Diaphragmatic and genioglossal electromyogram responses to isocapnic hypoxia in humans","volume":"1981","author":"Onal, E.; Lopata, M.; O'Connor, T.","unstructured":"Onal E, Lopata M, O'Connor T. Diaphragmatic and genioglossal electromyogram responses to isocapnic hypoxia in humans. Am Rev Respir Dis 1981,124:215-7","journal-title":"Am Rev Respir Dis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1152\/jappl.1981.50.5.1052","article-title":"Diaphragmatic and genioglossal EMG responses to CO2 rebreathing in humans","volume":"50","author":"Onal, E.; Lopata, M.; O'Connor, T.","year":"1981","unstructured":"Onal E, Lopata M, O'Connor T. Diaphragmatic and genioglossal EMG responses to CO2 rebreathing in humans. 7 Appl Physiol 1981;50:1052-55.","journal-title":"7 Appl Physiol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1152\/jappl.1984.56.2.500","article-title":"Upper airway pressure effects on respiratory activity of upper airway muscles","volume":"56","author":"Mathew, O.P.","year":"1984","unstructured":"Mathew OP. Upper airway pressure effects on respiratory activity of upper airway muscles. Appl Physiol 1984;56: 500-5.","journal-title":"Appl Physiol"},{"key":"ref_21","first-page":"438","article-title":"Influence of upper airway pressure charges on genioglossal muscle respiratory activity","volume":"52","author":"Mathew, O.P.; Abu-Osba, Y.K.; Thach, B.T.","year":"1982","unstructured":"Mathew OP, Abu-Osba YK, Thach BT. Influence of upper airway pressure charges on genioglossal muscle respiratory activity. _ ApplPhysiol 1982;52:438-44.","journal-title":"_ ApplPhysiol"},{"key":"ref_22","first-page":"15","article-title":"Evidence for reflex upper airway dilator muscle activation by sudden negative airway pressure","volume":"436","author":"Homer, R.L.; Innes, J.A.; Murphy, K.; Guy, A.","year":"1991","unstructured":"Homer RL, Innes JA, Murphy K, Guy A. Evidence for reflex upper airway dilator muscle activation by sudden negative airway pressure in man. 7 Physiol (1Lond) 1991; 436:15-29."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1164\/ajrccm\/148.3.597","article-title":"Influence of sleep on genioglossal muscle activation by negative pressure in normal men","volume":"148","author":"Wheatley, JR, Mezzanotte; WS, Tangel; DJ, White; D.P.","year":"1993","unstructured":"Wheatley JR, Mezzanotte WS, Tangel DJ, White DP. Influence of sleep on genioglossal muscle activation by negative pressure in normal men. Anm Rezv Respir Dis 1993; 148:597-605.","journal-title":"Anm Rezv Respir Dis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1113\/jphysiol.1991.sp018537","article-title":"Afferent pathways for pharyngeal dilator reflex to negative pressure in man: a study using upper airway anesthesia","volume":"436","author":"Homer, R.L.; Innes, J.A.; Holden, H.B.; Guy, A.","year":"1991","unstructured":"Homer RL, Innes JA, Holden HB, Guy A. Afferent pathways for pharyngeal dilator reflex to negative pressure in man: a study using upper airway anesthesia. 7 Phsio (Lond) 1991;436:31-44.","journal-title":"7 Phsio (Lond)"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1152\/jn.1983.50.5.1098","article-title":"The consistency and signal strength of respiratorvneuronal activity","volume":"50","author":"Orem, J.; Dick, T.","year":"1983","unstructured":"Orem J, Dick T. The consistency and signal strength of respiratorvneuronal activity. _Neiurophysiol 1983;50: 1098-107.","journal-title":"_Neiurophysiol"},{"key":"ref_26","first-page":"1144","article-title":"Activity of respiratorv neurons during NREM sleep..7 Neuirophysiol","volume":"54","author":"Orem, J.; Osconro, E.; Brooks, E.; Dick, T.","year":"1985","unstructured":"Orem J, Osconro E, Brooks E, Dick T. Activity of respiratorv neurons during NREM sleep..7 Neuirophysiol 1985;54: 1144-56."},{"key":"ref_27","first-page":"1381542","article-title":"Palate and hypopharynx - sites of inspiratory narrowing of the upper airway during sleep","author":"Hudgel, D.W.","year":"1988","unstructured":"Hudgel DW. Palate and hypopharynx - sites of inspiratory narrowing of the upper airway during sleep. Am Rev Respir Dis 1988;1381542-7.","journal-title":"Am Rev Respir Dis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1152\/jappl.1989.66.4.1800","article-title":"Collapsibility of the human airway during normal sleep","volume":"66","author":"Wiegand 1, Zwillich CW, White DP","year":"1989","unstructured":"Wiegand 1, Zwillich CW, White DP. Collapsibility of the human airway during normal sleep. Y Appl Physiol 1989; 66:1800-8.","journal-title":"Y Appl Physiol"},{"key":"ref_29","first-page":"221","article-title":"Computerized tomography in obstructive sleep apnea: correlation of airway size with physiology during sleep and wakefulness","volume":"127","author":"Haponik, E.; Smith, P.; Bohlman, M.; Allan, R.; Goldman, S.; Bleecher, E.","year":"1983","unstructured":"Haponik E, Smith P, Bohlman M, Allan R, Goldman S, Bleecher E. Computerized tomography in obstructive sleep apnea: correlation of airway size with physiology during sleep and wakefulness. Amii Rev Respir Dos 1983; 127:221.","journal-title":"Amii Rev Respir Dos"},{"key":"ref_30","first-page":"335","article-title":"Upper airway morphology in patients with idiopathetic obstructive sleep apnea","volume":"129","author":"Rivlin, J.; Hoffstein, V.; Klabfleisch, J.; McNicholas, W.; Zamel, N.; Bryan, A.","year":"1984","unstructured":"Rivlin J, Hoffstein V, Klabfleisch J, McNicholas W, Zamel N, Bryan A. Upper airway morphology in patients with idiopathetic obstructive sleep apnea. Am Rev Respir Dis 1984;129:335.","journal-title":"Am Rev Respir Dis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1164\/ajrccm\/136.3.623","article-title":"Pharyngeal size and resistance in obstructive sleep apnea","volume":"136","author":"Stauffer, J.L.; Zwillich, C.W.; Cadieux, R.J.; Bixler, E.D.; Kales, A.; Varano, L.A.; White, D.P.","year":"1987","unstructured":"Stauffer JL, Zwillich CW, Cadieux RJ, Bixler ED, Kales A, Varano LA, White DP. Pharyngeal size and resistance in obstructive sleep apnea. Am Rev Respir Dis 1987;136: 623-7.","journal-title":"Am Rev Respir Dis"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1164\/ajrccm\/148.1.185","article-title":"Upper airway dilating muscle hyperactivity during non-rapid eye movement sleep in English bulldogs","volume":"148","author":"Hendricks, J.C.; Petrof, B.; Pancheri, K.; Al, Pack","year":"1993","unstructured":"Hendricks JC, Petrof B, Pancheri K, Pack Al. Upper airway dilating muscle hyperactivity during non-rapid eye movement sleep in English bulldogs. Ant Rev Respir Dis 1993; 148:185-94.","journal-title":"Ant Rev Respir Dis"},{"key":"ref_33","first-page":"345","article-title":"The effect of sleep upon the patellar tendor reflex","volume":"68","author":"Tuttle, W.W.","year":"1924","unstructured":"Tuttle WW. The effect of sleep upon the patellar tendor reflex. AnJI Physiol 1924;68:345-8.","journal-title":"AnJI Physiol"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0013-4694(64)90229-9","article-title":"Depression of electrically induced reflexes (\"H-reflexes\") in man during low voltage EEG \"sleep\"","volume":"17","author":"Hodes, R.; Dement, W.C.","year":"1964","unstructured":"Hodes R, Dement WC. Depression of electrically induced reflexes (\"H-reflexes\") in man during low voltage EEG \"sleep\". Electroencephalogr Clin Neiirophysiol 1964; 17:617-29.","journal-title":"Electroencephalogr Clin Neiirophysiol"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0006-8993(66)90078-3","article-title":"The fusimotor activity and natural sleep in the cat","volume":"3","author":"Kubota, K.; Tanaka, R.","year":"1966","unstructured":"Kubota K, Tanaka R. The fusimotor activity and natural sleep in the cat. Brain Res 1966;3:198-201.","journal-title":"Brain Res"},{"key":"ref_36","first-page":"676","article-title":"Periodic breathing and the pathogenesis of occlusive sleep apneas","volume":"126","author":"Onal, E.; Lopata, M.","year":"1982","unstructured":"Onal E, Lopata M. Periodic breathing and the pathogenesis of occlusive sleep apneas. Ani Rev Respir Dis 1982;126: 676-80.","journal-title":"Ani Rev Respir Dis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1152\/jappl.1990.69.2.443","article-title":"Fluctuation in timing of upper airway and chest wall inspiratory muscle activity in obstructive sleep apnea","volume":"69","author":"Hudgel, D.W.; Harasick, T.","year":"1990","unstructured":"Hudgel DW, Harasick T. Fluctuation in timing of upper airway and chest wall inspiratory muscle activity in obstructive sleep apnea. _7 Appl Physiol 1990;69:443-50.","journal-title":"_7 Appl Physiol"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1378\/chest.92.5.918","article-title":"Concerning the importance of pharyngeal muscles in the maintenance of upper airway patency during sleep. An opinion","volume":"92","author":"Strohl, K.P.; Olson, L.G.","year":"1987","unstructured":"Strohl KP, Olson LG. Concerning the importance of pharyngeal muscles in the maintenance of upper airway patency during sleep. An opinion. Chest 1987;92:918-20.","journal-title":"Chest"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1152\/jappl.1988.65.5.2124","article-title":"Thoracic influence on upper airway patency","volume":"65","author":"de Graff WB, Van","year":"1988","unstructured":"Van de Graff WB. Thoracic influence on upper airway patency. _7 Appl Physiol 1988;65:2124-31.","journal-title":"_7 Appl Physiol"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1152\/jappl.1985.59.5.1364","article-title":"Physiologic determinants of nocturnal arterial oxygenation in patients with obstructive sleep apnea","volume":"59","author":"Bradley, T.D.; Martinez, D.; Rutherford, R.; Lue, F.; Grossman, R.F.; Moldofsky, H.","year":"1985","unstructured":"Bradley TD, Martinez D, Rutherford R, Lue F, Grossman RF, Moldofsky H, et al. Physiologic determinants of nocturnal arterial oxygenation in patients with obstructive sleep apnea. Appl Physiol 1985;59:1364-8.","journal-title":"Appl Physiol"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1152\/jappl.1986.61.4.1279","article-title":"Occlusion pressure and ventilation during sleep in normal humans","volume":"61","author":"White, D.P.","year":"1986","unstructured":"White DP. Occlusion pressure and ventilation during sleep in normal humans. Appl Physiol 1986;61:1908-13. JV, 42 Douglas NJ, White DP, Prickett CK, Weil Zwillich CW.","journal-title":"Appl Physiol"},{"key":"ref_42","first-page":"286","article-title":"Hypoxia ventilatory response decreases during sleep in man","volume":"125","author":"Douglas, N.J.; White, D.P.; Weil, J.V.; Prickett, C.K.; Martin, R.J.; Hudgel, D.W.","year":"1982","unstructured":"Douglas NJ, White DP, Weil JV, Prickett CK, Martin RJ, Hudgel DW, et al. Hypoxia ventilatory response decreases during sleep in man. Am Rev Respir Dis 1982;125:286-9.","journal-title":"Am Rev Respir Dis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1152\/jappl.1987.62.5.1832","article-title":"Arousal responses to airway occlusion in sleeping dogs: comparison of nasal and tracheal occlusions","volume":"62","author":"Issa, F.G.; McNamara, S.G.; Sullivan, C.E.","year":"1987","unstructured":"Issa FG, McNamara SG, Sullivan CE. Arousal responses to airway occlusion in sleeping dogs: comparison of nasal and tracheal occlusions. Appl Physiol 1987;62:1832-6.","journal-title":"Appl Physiol"},{"key":"ref_44","first-page":"644","article-title":"Phillipson vagal EA. Role of carotid body and of afferent stimuli in the arousal response to airway occlusion in sleeping dogs","volume":"123","author":"Bowes, G.; Townsend, E.R.; Bromley, S.M.; Kozar, L.F.","year":"1981","unstructured":"Bowes G, Townsend ER, Bromley SM, Kozar LF, Phillipson vagal EA. Role of carotid body and of afferent stimuli in the arousal response to airway occlusion in sleeping dogs. Amn Rev Respir Dis 1981;123:644-7.","journal-title":"Amn Rev Respir Dis"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1152\/jappl.1981.51.1.40","article-title":"Effect of carotid body denervation on arousal response in sleeping dogs","volume":"51","author":"Bowes, G.; Townsend, E.R.; Kozar, L.F.; Bromley, S.M.; Phillipson, E.A.","year":"1981","unstructured":"Bowes G, Townsend ER, Kozar LF, Bromley SM, Phillipson EA. Effect of carotid body denervation on arousal response in sleeping dogs.. Appl Physiol 1981 l51:40-5.","journal-title":"Appl Physiol"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1152\/jappl.1984.57.1.59","article-title":"Ventilation and arousal responses to hypercapnic in normal sleeping humans","volume":"54","author":"Berthon-Jones, M.; Sullivan, C.E.","year":"1984","unstructured":"Berthon-Jones M, Sullivan CE. Ventilation and arousal responses to hypercapnic in normal sleeping humans. Appl Physiol 1984;54:59-67.","journal-title":"Appl Physiol"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1164\/ajrccm\/145.2_Pt_1.445","article-title":"Effect of ethanol on the arousal response to airway occlusion during sleep in normal subjects","volume":"145","author":"Berry, R.B.; Bonnet, M.H.; Light, R.W.","year":"1992","unstructured":"Berry RB, Bonnet MH, Light RW. Effect of ethanol on the arousal response to airway occlusion during sleep in normal subjects. Am Rev Respir Dis 1992;145:445-52.","journal-title":"Am Rev Respir Dis"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1164\/ajrccm\/143.6.1274","article-title":"Interaction of chemical and mechanical respiratory stimuli in the arousal response to hypoxia in sleeping dogs","volume":"143","author":"Yosuma, F.; Kozar, L.F.; RJ, Kimoff Bradley; TD, Phillipson; E.A.","year":"1991","unstructured":"Yosuma F, Kozar LF, RJ, Kimoff Bradley TD, Phillipson EA. Interaction of chemical and mechanical respiratory stimuli in the arousal response to hypoxia in sleeping dogs. Am Rev Respir Dis 1991;143:1274-7.","journal-title":"Am Rev Respir Dis"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.50.7.797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T19:15:37Z","timestamp":1632770137000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.50.7.797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7,1]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1995,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/thx.50.7.797","relation":{},"ISSN":["0040-6376"],"issn-type":[{"value":"0040-6376","type":"print"}],"subject":[],"published":{"date-parts":[[1995,7,1]]}}}