{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T23:53:26Z","timestamp":1774914806651,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1136\/thx.52.10.845","type":"journal-article","created":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T19:40:22Z","timestamp":1263238822000},"page":"845-848","source":"Crossref","is-referenced-by-count":75,"title":["Effect of single doses of S-salbutamol, R-salbutamol, racemic salbutamol, and placebo on the airway response to methacholine."],"prefix":"10.1136","volume":"52","author":[{"given":"D W","family":"Cockcroft","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V A","family":"Swystun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02772204","article-title":"Anomalous effects of albuterol and other sympathomimetics in the guinea pig","volume":"14","author":"Morley, J.","year":"1996","unstructured":"Morley J. Anomalous effects of albuterol and other sympathomimetics in the guinea pig. Clin Rev Allergy Immunol 1996;14:65\u201389.","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0140-6736(90)93098-A","article-title":"Regular inhaled beta-agonist treatment in bronchial asthma","volume":"336","author":"Sears, M.R.; Taylor, D.R.; Print, C.G.; Lake, D.C.; Li, Q.; Flannery, E.M.","year":"1990","unstructured":"Sears MR, Taylor DR, Print CG, Lake DC, Li Q, Flannery EM, et al. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet 1990;336:1391\u20136.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/thx.51.10.1051","article-title":"Functional antagonism: tolerance produced by inhaled 2 agonists","volume":"51","author":"Cockcroft, D.W.; Swystun, V.A.","year":"1996","unstructured":"Cockcroft DW, Swystun VA. Functional antagonism: tolerance produced by inhaled 2 agonists. Thorax 1996;51: 1051\u20136.","journal-title":"Thorax"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0140-6736(93)92695-P","article-title":"Regular inhaled salbutamol and airway responsiveness to allergen","volume":"342","author":"Cockcroft, D.W.; McParland, C.P.; Britto, S.A.; Swystun, V.A.; Rutherford, B.C.","year":"1993","unstructured":"Cockcroft DW, McParland CP, Britto SA, Swystun VA, Rutherford BC. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet 1993;342:833\u20137.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0091-6749(95)70031-5","article-title":"Regular use of inhaled albuterol and the allergen-induced late asthmatic response","volume":"96","author":"Cockcroft, D.W.; O\u2019Byrne, P.M.; Swystun, V.A.; Bhagat, R.","year":"1995","unstructured":"Cockcroft DW, O\u2019Byrne PM, Swystun VA, Bhagat R. Regular use of inhaled albuterol and the allergen-induced late asthmatic response. J Allergy Clin Immunol 1995;96:44\u20139.","journal-title":"J Allergy Clin Immunol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2222.1977.tb01448.x","article-title":"Bronchial reactivity to inhaled histamine: a method and clinical survey","volume":"7","author":"Cockcroft, D.W.; Killian, D.N.; Mellon, J.J.A.; Hargreave, F.E.","year":"1977","unstructured":"Cockcroft DW, Killian DN, Mellon JJA, Hargreave FE. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy 1977;7:235\u201343.","journal-title":"Clin Allergy"},{"key":"ref_7","article-title":"Histamine and methacholine inhalation tests: tidal breathing method: laboratory procedure and standardisation","author":"Juniper, E.F.; Cockcroft, D.W.; Hargreave, F.E.","year":"1991","unstructured":"Juniper EF, Cockcroft DW, Hargreave FE. Histamine and methacholine inhalation tests: tidal breathing method: laboratory procedure and standardisation. Lund, Sweden: AB Draco, 1991."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1378\/chest.84.4.505","article-title":"Determination of histamine PC20: comparison of linear and logarithmic interpolation","volume":"84","author":"Cockcroft, D.W.; Murdock, K.Y.; Mink, J.T.","year":"1983","unstructured":"Cockcroft DW, Murdock KY, Mink JT. Determination of histamine PC20: comparison of linear and logarithmic interpolation. Chest 1983;84:505\u20136.","journal-title":"Chest"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0140-6736(95)91775-6","article-title":"Salbutamol in the treatment of asthma","volume":"345","author":"Perrin-Fayolle, M.","year":"1995","unstructured":"Perrin-Fayolle M. Salbutamol in the treatment of asthma. Lancet 1995;345:1101.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1378\/chest.102.3.775","article-title":"Repeated methacholine challenge produces tolerance in normal but not in asthmatic subjects","volume":"102","author":"Beckett, W.S.; Marenberg, M.E.; Pace, P.E.","year":"1992","unstructured":"Beckett WS, Marenberg ME, Pace PE. Repeated methacholine challenge produces tolerance in normal but not in asthmatic subjects. Chest 1992;102:775\u20139.","journal-title":"Chest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1378\/chest.83.5.751","article-title":"Unimodal distribution of bronchial responsiveness to inhaled histamine in a random human population","volume":"83","author":"Cockcroft, D.W.; Berscheid, B.A.; Murdock, K.Y.","year":"1983","unstructured":"Cockcroft DW, Berscheid BA, Murdock KY. Unimodal distribution of bronchial responsiveness to inhaled histamine in a random human population. Chest 1983;83: 751\u20134.","journal-title":"Chest"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1136\/thx.42.5.361","article-title":"Prevalence of bronchial hyperresponsiveness and asthma in a rural adult population","volume":"42","author":"Woolcock, A.J.; Peat, J.K.; Salome, C.M.; Yan, K.; Anderson, S.D.; Schoeffel, R.E.","year":"1987","unstructured":"Woolcock AJ, Peat JK, Salome CM, Yan K, Anderson SD, Schoeffel RE, et al. Prevalence of bronchial hyperresponsiveness and asthma in a rural adult population. Thorax 1987;42:361\u20138.","journal-title":"Thorax"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.52.10.845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:25:51Z","timestamp":1601112351000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.52.10.845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":12,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1997,10,1]]},"published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1136\/thx.52.10.845"],"URL":"https:\/\/doi.org\/10.1136\/thx.52.10.845","relation":{},"ISSN":["0040-6376","1468-3296"],"issn-type":[{"value":"0040-6376","type":"print"},{"value":"1468-3296","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}