{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:56:43Z","timestamp":1792058203103,"version":"4.4.0"},"reference-count":38,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorax"],"published-print":{"date-parts":[[1997,8,1]]},"DOI":"10.1136\/thx.52.8.702","type":"journal-article","created":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T19:40:22Z","timestamp":1263238822000},"page":"702-708","source":"Crossref","is-referenced-by-count":168,"title":["Optimal treatment of descending necrotising mediastinitis"],"prefix":"10.1136","volume":"52","author":[{"given":"M. J.","family":"Corsten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. M.","family":"Shamji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. F.","family":"Odell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Frederico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. G.","family":"Laframboise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vallieres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Matzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"issue":"108","key":"ref_1","first-page":"588","article-title":"Mediastinitis following cervical suppuration","volume":"1938","author":"Pearse, H.E.","unstructured":"Pearse HE. Mediastinitis following cervical suppuration. Ann Surg 1938;108:588\u2013611.","journal-title":"Ann Surg"},{"key":"ref_2","first-page":"545","article-title":"Descending necrotizing mediastinitis","volume":"157","author":"Estrera, A.S.; Landay, M.J.; Grisham, J.M.; Sinn, D.P.; Platt, M.R.","year":"1983","unstructured":"Estrera AS, Landay MJ, Grisham JM, Sinn DP, Platt MR. Descending necrotizing mediastinitis. Surg Gynecol Obstet 1983;157:545\u201352.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/archotol.1970.04310040071013","article-title":"Nonclostridial deep gas-producing infection in the neck","volume":"92","author":"Albertsen, J.; Thomsen, E.M.","year":"1970","unstructured":"Albertsen J, Thomsen EM. Nonclostridial deep gas-producing infection in the neck. Arch Otolaryngol 1970;92: 383\u20135.","journal-title":"Arch Otolaryngol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1001\/archotol.1971.00770060932017","article-title":"Fatal mediastinitis following retropharyngeal abscess","volume":"93","author":"Janecka, I.P.; Rankow, R.M.","year":"1971","unstructured":"Janecka IP, Rankow RM. Fatal mediastinitis following retropharyngeal abscess. Arch Otolaryngol 1971;93:630\u20133.","journal-title":"Arch Otolaryngol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0030-4220(73)90207-7","article-title":"Necrotizing mediastinitis secondary to descending cervical cellulitis","volume":"36","author":"Cogan, M.I.C.","year":"1973","unstructured":"Cogan MIC. Necrotizing mediastinitis secondary to descending cervical cellulitis. Oral Surg 1973;36:307\u201320.","journal-title":"Oral Surg"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1001\/jama.1976.03270100048029","article-title":"Nontraumatic mediastinitis","volume":"236","author":"Enquist, R.W.; Blanck, R.R.; Butler, R.H.","year":"1976","unstructured":"Enquist RW, Blanck RR, Butler RH. Nontraumatic mediastinitis. JAMA 1976;236:1048\u20139.","journal-title":"JAMA"},{"key":"ref_7","first-page":"894","article-title":"Case 15-1978. Case records of the Massachusetts General Hospital","volume":"298","author":"Scully, R.E.; Galdabini, J.J.; McNeely, B.U.","year":"1978","unstructured":"Scully RE, Galdabini JJ, McNeely BU. Case 15-1978. Case records of the Massachusetts General Hospital. N Engl J Med 1978;298:894\u2013902.","journal-title":"N Engl J Med"},{"key":"ref_8","first-page":"308","article-title":"Fatal mediastinitis secondary to odontogenic infection","volume":"36","author":"Hendler, B.H.; Quinn, P.D.","year":"1978","unstructured":"Hendler BH, Quinn PD. Fatal mediastinitis secondary to odontogenic infection. J Oral Surg 1978;36:308\u201310.","journal-title":"J Oral Surg"},{"key":"ref_9","first-page":"223","article-title":"Ludwig angina, empyema, pulmonary infiltration, and pericarditis secondary to extraction of a tooth","volume":"38","author":"Strauss, H.R.; Tilghman, D.M.; Hankins, J.","year":"1980","unstructured":"Strauss HR, Tilghman DM, Hankins J. Ludwig angina, empyema, pulmonary infiltration, and pericarditis secondary to extraction of a tooth. J Oral Surg 1980;38: 223\u20139.","journal-title":"J Oral Surg"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0022-5223(19)37822-5","article-title":"Extrapleural empyema thoracis as a direct extension of Ludwig\u2019s angina","volume":"80","author":"Young, J.N.; Samson, P.C.","year":"1980","unstructured":"Young JN, Samson PC. Extrapleural empyema thoracis as a direct extension of Ludwig\u2019s angina. J Thorac Cardiovasc Surg 1980;80:25\u20137.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0003-4975(10)61458-0","article-title":"Successful management of mediastinitis, pleural empyema, and aortopulmonary fistula from odontogenic infection","volume":"35","author":"Economopoulos, G.C.; Scherzer, H.H.; Gryboski, W.A.","year":"1983","unstructured":"Economopoulos GC, Scherzer HH, Gryboski WA. Successful management of mediastinitis, pleural empyema, and aortopulmonary fistula from odontogenic infection. Ann Thorac Surg 1983;35:184\u20137.","journal-title":"Ann Thorac Surg"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/archotol.1983.00800150057011","article-title":"Purulent mediastinal abscess secondary to Ludwig\u2019s angina","volume":"109","author":"Snow, N.; Lucas, A.E.; Grau, M.; Steiner, M.","year":"1983","unstructured":"Snow N, Lucas AE, Grau M, Steiner M. Purulent mediastinal abscess secondary to Ludwig\u2019s angina. Arch Otolaryngol 1983;109:53\u20135.","journal-title":"Arch Otolaryngol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0266-4356(85)90001-4","article-title":"Subphrenic and mediastinal abscess formation: a complication of Ludwig\u2019s angina","volume":"23","author":"Bounds, G.A.","year":"1985","unstructured":"Bounds GA. Subphrenic and mediastinal abscess formation: a complication of Ludwig\u2019s angina. Br J Oral Maxillofac Surg 1985;23:313\u201321.","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0278-2391(87)80015-0","article-title":"Fatal necrotizing mediastinitis as a complication of an odontogenic infection","volume":"45","author":"Rubin, M.M.; Cozzi, G.M.","year":"1987","unstructured":"Rubin MM, Cozzi GM. Fatal necrotizing mediastinitis as a complication of an odontogenic infection. J Oral Maxillofac Surg 1987;45:529\u201333.","journal-title":"J Oral Maxillofac Surg"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0278-2391(88)90421-1","article-title":"Mediastinitis, thoracic empyema, and pericarditis as complications of a dental abscess: report of a case","volume":"46","author":"Zachariades, N.; Mezitis, M.; Stavrinidis, P.; KonsolakiAgouridaki, E.","year":"1988","unstructured":"Zachariades N, Mezitis M, Stavrinidis P, KonsolakiAgouridaki E. Mediastinitis, thoracic empyema, and pericarditis as complications of a dental abscess: report of a case. J Oral Maxillofac Surg 1988;46:493\u20135.","journal-title":"J Oral Maxillofac Surg"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0266-4356(89)90084-3","article-title":"Mediastinitis and pericarditis caused by dental infection","volume":"27","author":"Musgrove, B.T.; Malden, N.J.","year":"1989","unstructured":"Musgrove BT, Malden NJ. Mediastinitis and pericarditis caused by dental infection. Br J Oral Maxillofac Surg 1989; 27:423\u20138.","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref_17","first-page":"859","article-title":"Descending necrotizing mediastinitis","volume":"50","author":"Horowitz, M.D.; Sosa, J.L.; Lickstein, D.A.","year":"1990","unstructured":"Horowitz MD, Sosa JL, Lickstein DA. Descending necrotizing mediastinitis. Ann Thorac Surg 1990;50:859\u201360."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1742-1241.1990.tb10130.x","article-title":"Life-threatening peripharyngeal sepsis with mediastinitis","volume":"44","author":"Baker, A.R.; Moir, A.A.; Donnelly, P.K.","year":"1990","unstructured":"Baker AR, Moir AA, Donnelly PK. Life-threatening peripharyngeal sepsis with mediastinitis. Br J Clin Pract 1990; 44:640\u20131.","journal-title":"Br J Clin Pract"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/thx.45.6.491","article-title":"Mediastinitis and bilateral thoracic empyema complicating adult epiglottitis","volume":"45","author":"Chong, W.H.; Woodhead, M.A.; Millard, F.J.C.","year":"1990","unstructured":"Chong WH, Woodhead MA, Millard FJC. Mediastinitis and bilateral thoracic empyema complicating adult epiglottitis. Thorax 1990;45:491\u20132.","journal-title":"Thorax"},{"key":"ref_20","first-page":"54","article-title":"Fatal necrotizing mediastinitis secondary to acute suppurative parotitis","volume":"20","author":"Guardia, S.N.; Cameron, R.; Phillips, A.","year":"1991","unstructured":"Guardia SN, Cameron R, Phillips A. Fatal necrotizing mediastinitis secondary to acute suppurative parotitis. J Otolaryngol 1991;20:54\u20136.","journal-title":"J Otolaryngol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0735-6757(91)90011-8","article-title":"Mediastinitis following nasal intubation in the emergency department","volume":"9","author":"Seaman, M.; Ballinger, P.; Sturgill, T.D.; Maertins, M.","year":"1991","unstructured":"Seaman M, Ballinger P, Sturgill TD, Maertins M. Mediastinitis following nasal intubation in the emergency department. Am J Emerg Med 1991;9:37\u20139.","journal-title":"Am J Emerg Med"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0030-4220(92)90207-7","article-title":"Mediastinitis caused by odontogenic infection associated with adult respiratory distress syndrome","volume":"74","author":"Ogiso, A.; Tamura, M.; Minemura, T.; Kurashina, K.; Kotani, A.","year":"1992","unstructured":"Ogiso A, Tamura M, Minemura T, Kurashina K, Kotani A. Mediastinitis caused by odontogenic infection associated with adult respiratory distress syndrome. Oral Surg 1992; 74:15\u20138.","journal-title":"Oral Surg"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/clinids\/16.Supplement_4.S299","article-title":"Peritonsillar abscess, retropharyngeal abscess, mediastinitis, and nonclostridial anaerobic myonecrosis: a case report","volume":"16","author":"Civen, R.; Vaisanen, M.-L.; Finegold, S.M.","year":"1993","unstructured":"Civen R, Vaisanen M-L, Finegold SM. Peritonsillar abscess, retropharyngeal abscess, mediastinitis, and nonclostridial anaerobic myonecrosis: a case report. Clin Infect Dis 1993; 16:299\u2013303.","journal-title":"Clin Infect Dis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1136\/thx.49.11.1179","article-title":"Empyema and mediastinitis complicating retropharyngeal abscess","volume":"49","author":"Watanabe, M.; Ohshika, Y.; Aoki, T.; Takagi, K.; Tanaka, S.; Ogata, T.","year":"1994","unstructured":"Watanabe M, Ohshika Y, Aoki T, Takagi K, Tanaka S, Ogata T. Empyema and mediastinitis complicating retropharyngeal abscess. Thorax 1994;49:1179\u201380.","journal-title":"Thorax"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0278-2391(95)90404-2","article-title":"Cervical cellulitis and mediastinitis caused by odontogenic infections: report of two cases and review of literature","volume":"53","author":"Zeitoun, I.M.; Dhanarajani, P.J.","year":"1995","unstructured":"Zeitoun IM, Dhanarajani PJ. Cervical cellulitis and mediastinitis caused by odontogenic infections: report of two cases and review of literature. J Oral Maxillofac Surg 1995; 53:203\u20138.","journal-title":"J Oral Maxillofac Surg"},{"key":"ref_26","first-page":"60","article-title":"Necrotizing fasciitis of the head and neck with intrathoracic extension","volume":"24","author":"Jackson, B.S.; Sproat, J.E.","year":"1995","unstructured":"Jackson BS, Sproat JE. Necrotizing fasciitis of the head and neck with intrathoracic extension. J Otolaryngol 1995;24: 60\u20133.","journal-title":"J Otolaryngol"},{"key":"ref_27","first-page":"353","article-title":"Anaerobic mediastinitis","volume":"143","author":"Howell, H.S.; Prinz, R.A.; Pickleman, JR","year":"1976","unstructured":"Howell HS, Prinz RA, Pickleman JR. Anaerobic mediastinitis. Surg Gynecol Obstet 1976;143:353\u20139.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1378\/chest.73.4.497","article-title":"Mediastinitis from odontogenic and deep cervical infection","volume":"73","author":"Moncada, R.; Warpeha, R.; Pickleman, J.; Spak, M.; Cardoso, M.; Berkow, A.","year":"1978","unstructured":"Moncada R, Warpeha R, Pickleman J, Spak M, Cardoso M, Berkow A, et al. Mediastinitis from odontogenic and deep cervical infection. Chest 1978;73:497\u2013500.","journal-title":"Chest"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1288\/00005537-198107000-00010","article-title":"Complications of space infections of the head and neck","volume":"91","author":"Wills, P.I.; RP, Jr, Vernon","year":"1981","unstructured":"Wills PI, Vernon RP Jr. Complications of space infections of the head and neck. Laryngoscope 1981;91:1129\u201336.","journal-title":"Laryngoscope"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1288\/00005537-198607000-00009","article-title":"Mediastinitis occurring as a complication of odontogenic infections","volume":"96","author":"Levine, T.M.; Wurster, C.F.; Krespi, Y.P.","year":"1986","unstructured":"Levine TM, Wurster CF, Krespi YP. Mediastinitis occurring as a complication of odontogenic infections. Laryngoscope 1986;96:747\u201350.","journal-title":"Laryngoscope"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/0003-4975(90)90022-X","article-title":"Descending necrotizing mediastinitis: transcervical drainage is not enough","volume":"49","author":"Wheatley, M.J.; Stirling, M.C.; Kirsh, M.M.; Gago, O.; Orringer, M.B.","year":"1990","unstructured":"Wheatley MJ, Stirling MC, Kirsh MM, Gago O, Orringer MB. Descending necrotizing mediastinitis: transcervical drainage is not enough. Ann Thorac Surg 1990;49:780\u20134.","journal-title":"Ann Thorac Surg"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0901-5027(05)80707-6","article-title":"Mediastinitis from odontogenic infection","volume":"20","author":"Garatea-Crelgo, J.; Gay-Escoda, C.","year":"1991","unstructured":"Garatea-Crelgo J, Gay-Escoda C. Mediastinitis from odontogenic infection. Int J Oral Maxillofac Surg 1991;20:65\u20138.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/hed.2880130610","article-title":"Mediastinal and thoracic complications of necrotizing fasciitis of the head and neck","volume":"13","author":"Lalwani, A.K.; Caplan, M.J.","year":"1991","unstructured":"Lalwani AK, Caplan MJ. Mediastinal and thoracic complications of necrotizing fasciitis of the head and neck. Head and Neck 1991;13:531\u20139.","journal-title":"Head and Neck"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1010-5182(05)80151-9","article-title":"Thoracic complications of deeply situated serous neck infections","volume":"21","author":"Ruiz, C.C.; Diez, R.; Labajo, A.; Yanez Vilas, I.; Paniagua, J.","year":"1993","unstructured":"Ruiz CC, Diez R, Labajo A, Yanez Vilas I, Paniagua J. Thoracic complications of deeply situated serous neck infections. J Cranio-Maxillo-Fac Surg 1993;21:76\u201381.","journal-title":"J Cranio-Maxillo-Fac Surg"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0022-5223(94)70453-8","article-title":"Descending necrotizing mediastinitis. Advantage of mediastinal drainage with thoracotomy","volume":"107","author":"Marty-Ane, C.H.; Alauzen, M.; Alric, P.; Serres-Cousine, O.; Mary, H.","year":"1994","unstructured":"Marty-Ane CH, Alauzen M, Alric P, Serres-Cousine O, Mary H. Descending necrotizing mediastinitis. Advantage of mediastinal drainage with thoracotomy. J Thorac Cardiovasc Surg 1994;107:55\u201361.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1001\/archotol.1937.00650010611004","article-title":"Mediastinitis: a clinical study with practical anatomic considerations of the neck and mediastinum","volume":"25","author":"Furstenberg, A.C.; Yglesias, L.","year":"1937","unstructured":"Furstenberg AC, Yglesias L. Mediastinitis: a clinical study with practical anatomic considerations of the neck and mediastinum. Arch Otolaryngol 1937;25:539\u201354.","journal-title":"Arch Otolaryngol"},{"key":"ref_37","first-page":"362","article-title":"Anatomy \u2013 Regional and Applied","author":"Last, R.J.","year":"1984","unstructured":"Last RJ. Anatomy \u2013 Regional and Applied. New York: Churchill Livingstone, 1984:362\u20134."},{"key":"ref_38","first-page":"449","article-title":"CT evaluation of mediastinal infections","volume":"11","author":"Carrol, C.L.; Brooke, JR, Federle; MP, Vernacchia; F.S.","year":"1987","unstructured":"Carrol CL, Brooke JR, Federle MP, Vernacchia FS. CT evaluation of mediastinal infections. JCAT 1987;11:449\u2013 54.","journal-title":"JCAT"}],"container-title":["Thorax"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/thx.52.8.702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T17:08:57Z","timestamp":1711127337000},"score":1,"resource":{"primary":{"URL":"https:\/\/thorax.bmj.com\/lookup\/doi\/10.1136\/thx.52.8.702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8,1]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/thx.52.8.702","relation":{},"ISSN":["0040-6376"],"issn-type":[{"value":"0040-6376","type":"print"}],"subject":[],"published":{"date-parts":[[1997,8,1]]}}}